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ASC speck formation as a readout for inflammasome activation.
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Activation of the NLRP3 inflammasome in microglia: the role of ceramide.