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Latz, Eicke
One or more keywords matched the following items that are connected to Latz, Eicke
Item TypeName
Academic Article Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
Academic Article Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Academic Article IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Academic Article The LPS receptor generates inflammatory signals from the cell surface.
Academic Article Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
Academic Article The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Academic Article Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Academic Article SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Academic Article The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Academic Article TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Academic Article An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.
Academic Article RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Academic Article Intracellular DNA recognition.
Academic Article IFI16 is an innate immune sensor for intracellular DNA.
Academic Article The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Academic Article Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
Academic Article Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding.
Academic Article Innate immune receptors for nucleic acids.
Academic Article Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.
Academic Article KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.
Academic Article For gut's sake: NLRC4 inflammasomes distinguish friend from foe.
Academic Article Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
Academic Article Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Academic Article A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
Academic Article NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Academic Article Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Academic Article Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease.
Academic Article CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article ASC speck formation as a readout for inflammasome activation.
Academic Article The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
Academic Article Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Academic Article Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
Academic Article Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Academic Article The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Academic Article Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article Toll-like receptor interactions imaged by FRET microscopy and GFP fragment reconstitution.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Academic Article Inflammasomes: too big to miss.
Academic Article The inflammasomes: mechanisms of activation and function.
Academic Article Critical functions of priming and lysosomal damage for NLRP3 activation.
Academic Article Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Academic Article Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
Academic Article Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article NLRP3 inflammasomes link inflammation and metabolic disease.
Academic Article Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein.
Academic Article Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Academic Article PKR stirs up inflammasomes.
Academic Article Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.
Academic Article Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Academic Article Activation and regulation of the inflammasomes.
Academic Article Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Concept Protein-Tyrosine Kinases
Concept Membrane Proteins
Concept Protein Binding
Concept Protein Transport
Concept Adaptor Protein Complex 1
Concept DNA-Binding Proteins
Concept Amyloid beta-Protein Precursor
Concept Protein Folding
Concept Protein Processing, Post-Translational
Concept Ubiquitin-Protein Ligases
Concept Phosphate-Binding Proteins
Concept p38 Mitogen-Activated Protein Kinases
Concept Adaptor Protein Complex 2
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Phosphatase 2
Concept Carrier Proteins
Concept Proto-Oncogene Proteins c-bcl-2
Concept Chromosomal Proteins, Non-Histone
Concept Neuronal Apoptosis-Inhibitory Protein
Concept Cell Cycle Proteins
Concept Luminescent Proteins
Concept Protein Biosynthesis
Concept Protein Interaction Mapping
Concept Nuclear Proteins
Concept Recombinant Proteins
Concept S100 Proteins
Concept AMP-Activated Protein Kinases
Concept Intracellular Signaling Peptides and Proteins
Concept Protein Synthesis Inhibitors
Concept tau Proteins
Concept rhoA GTP-Binding Protein
Concept Viral Proteins
Concept Intercellular Signaling Peptides and Proteins
Concept HSP90 Heat-Shock Proteins
Concept rab GTP-Binding Proteins
Concept Complement System Proteins
Concept Proteins
Concept Fas-Associated Death Domain Protein
Concept Microtubule-Associated Proteins
Concept Receptor-Interacting Protein Serine-Threonine Kinases
Concept Membrane Transport Proteins
Concept Cytoskeletal Proteins
Concept Protein Structure, Tertiary
Concept Adaptor Proteins, Signal Transducing
Concept Interleukin 1 Receptor Antagonist Protein
Concept Kangai-1 Protein
Concept Protein Multimerization
Concept Green Fluorescent Proteins
Concept ras Proteins
Concept Bacterial Proteins
Concept Recombinant Fusion Proteins
Concept Calcium-Binding Proteins
Concept Bacterial Outer Membrane Proteins
Concept Protein Stability
Concept Neoplasm Proteins
Concept Drosophila Proteins
Concept Fas Ligand Protein
Concept Viral Fusion Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept Protein Isoforms
Concept Protein Conformation
Concept Apoptosis Regulatory Proteins
Concept Blood Proteins
Concept HMGB1 Protein
Concept Tumor Suppressor Proteins
Concept RNA-Binding Proteins
Concept CARD Signaling Adaptor Proteins
Academic Article HIV-1 induces the first signal to activate the NLRP3 inflammasome in monocyte-derived macrophages.
Academic Article Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Academic Article RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
Academic Article New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease.
Academic Article Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release.
Academic Article NLRC3 puts the brakes on STING.
Academic Article Innate immune activation in neurodegenerative disease.
Academic Article The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Academic Article LOX-1 and mitochondria: an inflammatory relationship.
Academic Article The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
Academic Article Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Academic Article NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1?.
Academic Article A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Academic Article Neuroinflammation in Alzheimer's disease.
Academic Article Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.
Academic Article Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
Academic Article ATF3 Is a Key Regulator of Macrophage IFN Responses.
Academic Article Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Academic Article Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET.
Academic Article Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.
Academic Article Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition.
Academic Article Interferons and inflammasomes: Cooperation and counterregulation in disease.
Academic Article A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice.
Academic Article An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in?mice.
Academic Article Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Academic Article Automated nanoscale flow cytometry for assessing protein-protein interactions.
Academic Article Dental Calculus Stimulates Interleukin-1? Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes.
Academic Article Assembly and regulation of ASC specks.
Academic Article Statins improve NASH via inhibition of RhoA and Ras.
Academic Article HMGB1, IL-1a, IL-33 and S100 proteins: dual-function alarmins.
Academic Article PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.
Academic Article Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.
Academic Article Soluble Uric Acid Activates the NLRP3 Inflammasome.
Academic Article Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Academic Article NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.
Academic Article Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
Academic Article Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Academic Article Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Academic Article Generation of Innate Immune Reporter Cells Using Retroviral Transduction.
Academic Article Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
Academic Article Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
Academic Article The intra- and extracellular functions of ASC specks.
Academic Article Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
Academic Article The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.
Academic Article Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Academic Article Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids.
Academic Article Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients.
Academic Article Inhibitory effects of colchicine on inflammasomes.
Academic Article NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.
Academic Article TAK1ng control: TAK1 restrains NLRP3 activation.
Academic Article NLRP3 inflammasome activation in inflammaging.
Academic Article Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation.
Academic Article The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Academic Article Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.
Academic Article Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages.
Academic Article DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways.
Academic Article Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.
Academic Article NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells.
Academic Article Alternative splicing regulates stochastic NLRP3 activity.
Academic Article AIM2 inflammasome-derived IL-1? induces postoperative ileus in mice.
Academic Article Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome.
Academic Article CD82 controls CpG-dependent TLR9 signaling.
Academic Article Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study.
Academic Article NLRP3 inflammasome activation drives tau pathology.
Academic Article Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Academic Article Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.
Academic Article PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment.
Academic Article ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Academic Article Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Academic Article Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent.
Academic Article Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.
Academic Article Crystal structure of the human NLRP9 pyrin domain suggests a distinct mode of inflammasome assembly.
Academic Article STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury.
Academic Article 1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
Academic Article Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.
Academic Article Interrelations of Alzheimer?s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
Academic Article The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles.
Academic Article Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid.
Academic Article Sensing soluble uric acid by Naip1-Nlrp3 platform.
Academic Article Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.
Academic Article N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.
Academic Article Cytosolic d-type CpG-oligonucleotides induce a type I interferon response by activating the cGAS-STING signaling pathway.
Academic Article Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.
Academic Article Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.
Academic Article Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies.
Academic Article Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Academic Article Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Academic Article BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Academic Article Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis.
Academic Article Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Academic Article Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease.
Academic Article Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Concept NLR Family, Pyrin Domain-Containing 3 Protein
Concept NLR Proteins
Concept Chitinase-3-Like Protein 1
Concept DEAD Box Protein 58
Concept Protein Domains
Concept Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Concept Fatty Acid Binding Protein 3
Concept GPI-Linked Proteins
Concept Protein Interaction Maps
Concept Protein Aggregation, Pathological
Concept Protein Aggregates
Academic Article Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Academic Article Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1.
Academic Article Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesicles.
Academic Article P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Academic Article ATP-binding and hydrolysis of human NLRP3.
Academic Article How location and cellular signaling combine to activate the NLRP3 inflammasome.
Academic Article Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.
Academic Article Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Academic Article Mitochondrial damage activates the NLRP10 inflammasome.
Academic Article Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.
Academic Article PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
Academic Article NULISA: a proteomic liquid biopsy platform with attomolar sensitivity and high multiplexing.
Academic Article Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
Academic Article UNC93B1 variants underlie TLR7-dependent autoimmunity.
Academic Article SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Academic Article NLRP3 inflammasome signalling in Alzheimer's disease.
Academic Article Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice.
Academic Article Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.
Academic Article ADA2 is a lysosomal deoxyadenosine deaminase acting on DNA involved in regulating TLR9-mediated immune sensing of DNA.
Academic Article Litomosoides sigmodontis microfilariae-induced eosinophil ETosis is dependent on the canonical inflammasome pathway.
Academic Article NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression.
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