| Item Type | Name |
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Academic Article
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The LPS receptor generates inflammatory signals from the cell surface.
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Academic Article
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An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.
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Academic Article
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Intracellular DNA recognition.
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Academic Article
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The sterile inflammatory response.
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Academic Article
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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
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Academic Article
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For gut's sake: NLRC4 inflammasomes distinguish friend from foe.
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Academic Article
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Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
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Academic Article
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
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Academic Article
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Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease.
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Academic Article
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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
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Academic Article
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IRF5, IRF8, and IRF7 in human pDCs - the good, the bad, and the insignificant?
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Academic Article
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The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
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Academic Article
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Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
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Academic Article
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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
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Academic Article
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Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
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Academic Article
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Inflammasomes: too big to miss.
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Academic Article
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The inflammasomes: mechanisms of activation and function.
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Academic Article
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
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Academic Article
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Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
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Academic Article
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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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Academic Article
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The critical role of IL-1 receptor-associated kinase 4-mediated NF-?B activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis.
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Academic Article
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The inflammasome in atherosclerosis and type 2 diabetes.
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Academic Article
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NLRP3 inflammasomes link inflammation and metabolic disease.
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Academic Article
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Intracellular sensing of microbes and danger signals by the inflammasomes.
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Academic Article
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IL-1, quo vadis?
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Academic Article
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Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
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Academic Article
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iGLuc: a luciferase-based inflammasome and protease activity reporter.
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Academic Article
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Activation and regulation of the inflammasomes.
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Concept
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Interleukin-10
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Concept
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Receptors, Interleukin-1
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Concept
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Interleukin-1alpha
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Concept
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Receptors, Interleukin-1 Type I
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Concept
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Interleukin-1 Receptor-Associated Kinases
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Concept
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Interleukin-1
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Concept
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Interleukin 1 Receptor Antagonist Protein
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Concept
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Interleukin-1beta
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Concept
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Interleukin-8
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Concept
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Interleukin-4
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Concept
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Interleukin-6
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Concept
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Receptors, Interleukin
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Concept
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Interleukin-18
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Academic Article
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HIV-1 induces the first signal to activate the NLRP3 inflammasome in monocyte-derived macrophages.
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Academic Article
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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
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Academic Article
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Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release.
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Academic Article
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Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.
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Academic Article
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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
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Academic Article
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The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
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Academic Article
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NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1?.
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Academic Article
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
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Academic Article
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Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.
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Academic Article
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TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition of Streptococcus pyogenes.
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Academic Article
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Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
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Academic Article
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Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
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Academic Article
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Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
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Academic Article
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Crystal Formation in Inflammation.
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Academic Article
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Interferons and inflammasomes: Cooperation and counterregulation in disease.
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Academic Article
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An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in?mice.
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Academic Article
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Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
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Academic Article
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Dental Calculus Stimulates Interleukin-1? Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes.
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Academic Article
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HMGB1, IL-1a, IL-33 and S100 proteins: dual-function alarmins.
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Academic Article
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Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.
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Academic Article
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Soluble Uric Acid Activates the NLRP3 Inflammasome.
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Academic Article
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Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
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Academic Article
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Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
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Academic Article
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Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
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Academic Article
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The intra- and extracellular functions of ASC specks.
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Academic Article
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Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
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Academic Article
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NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.
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Academic Article
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Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages.
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Academic Article
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Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis.
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Academic Article
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Blocking Inflammasome Activation Caused by ?-Amyloid Peptide (A?) and Islet Amyloid Polypeptide (IAPP) through an IAPP Mimic.
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Academic Article
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AIM2 inflammasome-derived IL-1? induces postoperative ileus in mice.
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Academic Article
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Author Correction: AIM2 inflammasome-derived IL-1? induces postoperative ileus in mice.
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Academic Article
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?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
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Academic Article
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Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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Sensing soluble uric acid by Naip1-Nlrp3 platform.
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Academic Article
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Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury.
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Academic Article
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IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice.
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Academic Article
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Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
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Academic Article
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BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
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Academic Article
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Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
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Concept
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Interleukin-33
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Academic Article
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How location and cellular signaling combine to activate the NLRP3 inflammasome.
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Academic Article
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Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.
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Academic Article
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Interferon-induced IL-10 drives systemic T-cell dysfunction during chronic liver injury.
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Academic Article
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Mitochondrial damage activates the NLRP10 inflammasome.
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Academic Article
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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.
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Academic Article
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PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
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