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Latz, Eicke

One or more keywords matched the following items that are connected to Latz, Eicke

Item Type	Name
Academic Article	Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Academic Article	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article	Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Academic Article	Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
Academic Article	Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Academic Article	SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.
Academic Article	The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article	Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Academic Article	TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Academic Article	An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.
Academic Article	RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate.
Academic Article	Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
Academic Article	Optimal oligonucleotide sequences for TLR9 inhibitory activity in human cells: lack of correlation with TLR9 binding.
Academic Article	Innate immune receptors for nucleic acids.
Academic Article	Critical role of nucleotide-binding oligomerization domain-like receptor 3 in vascular repair.
Academic Article	KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour suppressor function in gliomas.
Academic Article	Endothelial microparticle uptake in target cells is annexin I/phosphatidylserine receptor dependent and prevents apoptosis.
Academic Article	Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Academic Article	NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Academic Article	Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease.
Academic Article	CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article	Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Academic Article	Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
Academic Article	Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Academic Article	HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Academic Article	Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Academic Article	AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article	Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article	Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Academic Article	The inflammasomes: mechanisms of activation and function.
Academic Article	Critical functions of priming and lysosomal damage for NLRP3 activation.
Academic Article	Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Academic Article	NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Academic Article	Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
Academic Article	Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article	NLRP3 inflammasomes link inflammation and metabolic disease.
Academic Article	Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein.
Academic Article	Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Academic Article	PKR stirs up inflammasomes.
Academic Article	Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article	Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.
Academic Article	Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.
Academic Article	Activation and regulation of the inflammasomes.
Academic Article	Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Concept	Protein-Tyrosine Kinases
Concept	Protein Binding
Concept	Protein Transport
Concept	Adaptor Protein Complex 1
Concept	Amyloid beta-Protein Precursor
Concept	Protein Folding
Concept	Protein Processing, Post-Translational
Concept	Ubiquitin-Protein Ligases
Concept	p38 Mitogen-Activated Protein Kinases
Concept	Adaptor Protein Complex 2
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Protein Phosphatase 2
Concept	Neuronal Apoptosis-Inhibitory Protein
Concept	Protein Biosynthesis
Concept	Protein Interaction Mapping
Concept	AMP-Activated Protein Kinases
Concept	Protein Synthesis Inhibitors
Concept	rhoA GTP-Binding Protein
Concept	Fas-Associated Death Domain Protein
Concept	Receptor-Interacting Protein Serine-Threonine Kinases
Concept	Protein Structure, Tertiary
Concept	Interleukin 1 Receptor Antagonist Protein
Concept	Kangai-1 Protein
Concept	Protein Multimerization
Concept	Protein Stability
Concept	Fas Ligand Protein
Concept	Protein Isoforms
Concept	Protein Conformation
Concept	HMGB1 Protein
Academic Article	HIV-1 induces the first signal to activate the NLRP3 inflammasome in monocyte-derived macrophages.
Academic Article	RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.
Academic Article	New insights into mechanisms controlling the NLRP3 inflammasome and its role in lung disease.
Academic Article	Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Academic Article	Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article	Innate immune activation in neurodegenerative disease.
Academic Article	The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Academic Article	LOX-1 and mitochondria: an inflammatory relationship.
Academic Article	The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
Academic Article	Cutting edge: the UNC93B1 tyrosine-based motif regulates trafficking and TLR responses via separate mechanisms.
Academic Article	NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1?.
Academic Article	A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Academic Article	Neuroinflammation in Alzheimer's disease.
Academic Article	Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.
Academic Article	Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
Academic Article	ATF3 Is a Key Regulator of Macrophage IFN Responses.
Academic Article	Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Academic Article	Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET.
Academic Article	Measuring NLR Oligomerization II: Detection of ASC Speck Formation by Confocal Microscopy and Immunofluorescence.
Academic Article	Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition.
Academic Article	Interferons and inflammasomes: Cooperation and counterregulation in disease.
Academic Article	A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article	Ursodeoxycholic acid impairs atherogenesis and promotes plaque regression by cholesterol crystal dissolution in mice.
Academic Article	An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in?mice.
Academic Article	Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Academic Article	Automated nanoscale flow cytometry for assessing protein-protein interactions.
Academic Article	Dental Calculus Stimulates Interleukin-1? Secretion by Activating NLRP3 Inflammasome in Human and Mouse Phagocytes.
Academic Article	Assembly and regulation of ASC specks.
Academic Article	Statins improve NASH via inhibition of RhoA and Ras.
Academic Article	HMGB1, IL-1a, IL-33 and S100 proteins: dual-function alarmins.
Academic Article	PB1-F2 Peptide Derived from Avian Influenza A Virus H7N9 Induces Inflammation via Activation of the NLRP3 Inflammasome.
Academic Article	Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.
Academic Article	Soluble Uric Acid Activates the NLRP3 Inflammasome.
Academic Article	Human NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome activity is regulated by and potentially targetable through Bruton tyrosine kinase.
Academic Article	NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain.
Academic Article	Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
Academic Article	Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Academic Article	Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Academic Article	Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
Academic Article	Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
Academic Article	The intra- and extracellular functions of ASC specks.
Academic Article	Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
Academic Article	The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.
Academic Article	Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Academic Article	Lysine-containing cationic liposomes activate the NLRP3 inflammasome: Effect of a spacer between the head group and the hydrophobic moieties of the lipids.
Academic Article	Inhibitory effects of colchicine on inflammasomes.
Academic Article	NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis.
Academic Article	TAK1ng control: TAK1 restrains NLRP3 activation.
Academic Article	NLRP3 inflammasome activation in inflammaging.
Academic Article	The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Academic Article	Inflammasomes on the Crossroads of Innate Immune Recognition and Metabolic Control.
Academic Article	Charcot-Leyden Crystals Activate the NLRP3 Inflammasome and Cause IL-1? Inflammation in Human Macrophages.
Academic Article	DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways.
Academic Article	Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.
Academic Article	NLRP3 inflammasome-activating arginine-based liposomes promote antigen presentations in dendritic cells.
Academic Article	Alternative splicing regulates stochastic NLRP3 activity.
Academic Article	Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome.
Academic Article	CD82 controls CpG-dependent TLR9 signaling.
Academic Article	NLRP3 inflammasome activation drives tau pathology.
Academic Article	Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.
Academic Article	?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Academic Article	Platelets Fuel the Inflammasome Activation of Innate Immune Cells.
Academic Article	Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent.
Academic Article	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article	Bidirectional Role of NLRP3 During Acute and Chronic Cholestatic Liver Injury.
Academic Article	1-Deoxysphingolipids cause autophagosome and lysosome accumulation and trigger NLRP3 inflammasome activation.
Academic Article	Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.
Academic Article	Interrelations of Alzheimer?s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
Academic Article	The RNA-binding protein hnRNPU regulates the sorting of microRNA-30c-5p into large extracellular vesicles.
Academic Article	Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid.
Academic Article	Sensing soluble uric acid by Naip1-Nlrp3 platform.
Academic Article	Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.
Academic Article	N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.
Academic Article	Regulation of ubiquitin and ubiquitin-like modifiers by phosphorylation.
Academic Article	Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses.
Academic Article	Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies.
Academic Article	Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Academic Article	Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Academic Article	BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
Academic Article	Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis.
Academic Article	Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Academic Article	Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Concept	NLR Family, Pyrin Domain-Containing 3 Protein
Concept	Chitinase-3-Like Protein 1
Concept	DEAD Box Protein 58
Concept	Protein Domains
Concept	Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Concept	Fatty Acid Binding Protein 3
Concept	Protein Interaction Maps
Concept	Protein Aggregation, Pathological
Concept	Protein Aggregates
Academic Article	Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
Academic Article	Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1.
Academic Article	P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Academic Article	ATP-binding and hydrolysis of human NLRP3.
Academic Article	How location and cellular signaling combine to activate the NLRP3 inflammasome.
Academic Article	Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.
Academic Article	Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form.
Academic Article	Mitochondrial damage activates the NLRP10 inflammasome.
Academic Article	Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.
Academic Article	PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
Academic Article	Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1.
Academic Article	SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.
Academic Article	NLRP3 inflammasome signalling in Alzheimer's disease.
Academic Article	Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice.
Academic Article	Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.
Academic Article	NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression.

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