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Latz, Eicke

One or more keywords matched the following items that are connected to Latz, Eicke

Item Type	Name
Academic Article	Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Academic Article	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article	Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Academic Article	The LPS receptor generates inflammatory signals from the cell surface.
Academic Article	Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
Academic Article	The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Academic Article	An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4.
Academic Article	Intracellular DNA recognition.
Academic Article	The sterile inflammatory response.
Academic Article	IFI16 is an innate immune sensor for intracellular DNA.
Academic Article	The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes.
Academic Article	Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Academic Article	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article	LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article	Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Academic Article	TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article	Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
Academic Article	Mechanisms of TLR9 activation.
Academic Article	Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Academic Article	Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity.
Academic Article	The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article	HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Academic Article	Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article	Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Academic Article	Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article	Inflammasomes: too big to miss.
Academic Article	The inflammasomes: mechanisms of activation and function.
Academic Article	The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article	Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
Academic Article	Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article	Intracellular sensing of microbes and danger signals by the inflammasomes.
Academic Article	Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
Academic Article	Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article	Activation and regulation of the inflammasomes.
Concept	Signal Transduction
Academic Article	Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Academic Article	Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.
Academic Article	NLRC3 puts the brakes on STING.
Academic Article	Innate immune activation in neurodegenerative disease.
Academic Article	The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.
Academic Article	The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
Academic Article	Transcriptome assessment reveals a dominant role for TLR4 in the activation of human monocytes by the alarmin MRP8.
Academic Article	NLRP3 protein deficiency exacerbates hyperoxia-induced lethality through Stat3 protein signaling independent of interleukin-1?.
Academic Article	Danger signaling in atherosclerosis.
Academic Article	Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.
Academic Article	Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology.
Academic Article	Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.
Academic Article	Toll-Like Receptor Interactions Measured by Microscopic and Flow Cytometric FRET.
Academic Article	Interferons and inflammasomes: Cooperation and counterregulation in disease.
Academic Article	An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in?mice.
Academic Article	Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Academic Article	Statins improve NASH via inhibition of RhoA and Ras.
Academic Article	RAGE Enhances TLR Responses through Binding and Internalization of RNA.
Academic Article	ASC specks: a biomarker for myelodysplastic syndromes?
Academic Article	Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling.
Academic Article	Inflammasome signalling in brain function and neurodegenerative disease.
Academic Article	The intra- and extracellular functions of ASC specks.
Academic Article	The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.
Academic Article	Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension.
Academic Article	Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2.
Academic Article	NLRP3 inflammasome activation in inflammaging.
Academic Article	The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Academic Article	CD82 controls CpG-dependent TLR9 signaling.
Academic Article	Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase.
Academic Article	?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Academic Article	STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article	Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis.
Academic Article	Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid.
Academic Article	Cytosolic d-type CpG-oligonucleotides induce a type I interferon response by activating the cGAS-STING signaling pathway.
Academic Article	Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Academic Article	Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.
Academic Article	NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Academic Article	Primary cilia and their effects on immune cell functions and metabolism: a model.
Academic Article	NLRP3 inflammasome signalling in Alzheimer's disease.
Academic Article	Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation.

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Signal Transduction