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Please visit the Luban Lab Website

Professor Luban is a physician-scientist who studies the interaction between human cells and deadly pathogens including HIV-1, Ebola virus, and SARS-CoV-2. He has held endowed professorships at Columbia University in New York (where he directed the Columbia-Rockefeller Center for AIDS Research), the University of Geneva in Switzerland, and now the University of Massachusetts Medical School, where he holds the David J. Freelander Chair in AIDS Research. He is an affiliate of the Broad Institute of MIT and Harvard and oversees a program on SARS-CoV-2 as part of the Massachusetts Consortium on Pathogen Readiness. Dr. Luban was elected to the American Society for Clinical Investigation, the Association of American Physicians, and the American Academy of Microbiology. His research program in Virology, Immunology, and Molecular Biology has been continuously funded for the past 30 years by the National Institute of Health and includes Merit and Avant Garde Awards. He has served on editorial boards of four virology journals, on grant review committees and scientific advisory boards for the NIH, the American Cancer Society, the American Foundation for AIDS Research, and has acted as primary mentor for 90 Ph.D. students, post-docs, and undergraduate students.

One or more keywords matched the following items that are connected to Luban, Jeremy
Item TypeName
Academic Article Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.
Academic Article Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.
Academic Article Assignment of cyclophilin A (PPIA) to human chromosome band 7p13by in situ hybridization.
Academic Article Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription.
Academic Article Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.
Academic Article Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.
Academic Article Rescue of multiple viral functions by a second-site suppressor of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction.
Academic Article Human immunodeficiency virus type 1 virion density is not determined by nucleocapsid basic residues.
Academic Article Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions.
Academic Article Isolation, characterization and targeted disruption of mouse ppia: cyclophilin A is not essential for mammalian cell viability.
Academic Article The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article Context-dependent phenotype of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.
Academic Article Cyclophilin A peptidyl-prolyl isomerase activity promotes ZPR1 nuclear export.
Academic Article As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity.
Academic Article Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
Academic Article Production of ribosome components in effector CD4+ T cells is accelerated by TCR stimulation and coordinated by ERK-MAPK.
Academic Article AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis.
Academic Article HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.
Academic Article Blockade of late stages of autoimmune diabetes by inhibition of the receptor for advanced glycation end products.
Academic Article Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA.
Academic Article Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.
Academic Article Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein.
Academic Article Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Academic Article TRIM5alpha selectively binds a restriction-sensitive retroviral capsid.
Academic Article TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs.
Academic Article Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.
Academic Article G2 cell cycle arrest and cyclophilin A in lentiviral gene transfer.
Academic Article Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells.
Academic Article Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.
Academic Article Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxia-ischemia.
Academic Article HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase.
Academic Article Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Academic Article An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.
Academic Article The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon beta.
Academic Article Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.
Academic Article Human cellular restriction factors that target HIV-1 replication.
Academic Article Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1.
Academic Article HIV-1 and Ebola virus: the getaway driver nabbed.
Academic Article Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.
Academic Article p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.
Academic Article Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation.
Academic Article Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection.
Academic Article Deciphering the code for retroviral integration target site selection.
Academic Article TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.
Academic Article TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
Academic Article TRIM5a associates with proteasomal subunits in cells while in complex with HIV-1 virions.
Academic Article Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.
Academic Article Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.
Academic Article TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
Academic Article The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5a.
Academic Article More than one way to TRIM a capsid.
Academic Article TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.
Academic Article Cyclophilin A interacts with HIV-1 Vpr and is required for its functional expression.
Academic Article The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest.
Academic Article Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1.
Academic Article Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.
Academic Article Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection.
Academic Article Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1.
Academic Article ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity.
Academic Article Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine.
Academic Article Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells.
Academic Article Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner.
Academic Article Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.
Academic Article Cyclophilin, TRIM5, and innate immunity to HIV-1.
Academic Article Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection.
Academic Article The retroviral restriction factor TRIM5alpha.
Academic Article The role of lysine 186 in HIV-1 integrase multimerization.
Academic Article A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal.
Academic Article Lentiviral vector gene transfer is limited by the proteasome at postentry steps in various types of stem cells.
Academic Article Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.
Academic Article HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
Academic Article Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney.
Academic Article Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon.
Academic Article Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.
Academic Article TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling.
Academic Article TRIM5 and the Regulation of HIV-1 Infectivity.
Academic Article Innate immune sensing of HIV-1 by dendritic cells.
Academic Article HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.
Academic Article Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay.
Academic Article Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.
Academic Article Cyclophilin and gag in HIV-1 replication and pathogenesis.
Academic Article Specific incorporation of cyclophilin A into HIV-1 virions.
Academic Article Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays.
Academic Article Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
Concept Cytokines
Concept T-Lymphocytes, Cytotoxic
Concept Disease Models, Animal
Concept SOXB1 Transcription Factors
Concept Drug Resistance, Viral
Concept Temperature
Concept beta Karyopherins
Concept Genes, env
Concept Subcellular Fractions
Concept Interferon-beta
Concept Hypoxia-Ischemia, Brain
Concept NF-kappa B
Concept Heat-Shock Proteins
Concept Endogenous Retroviruses
Concept Software
Concept Neuregulins
Concept Mitochondria
Concept Flow Cytometry
Concept CD4 Antigens
Concept Introns
Concept HeLa Cells
Concept Diphtheria-Tetanus-Pertussis Vaccine
Concept Exodeoxyribonucleases
Concept Hepacivirus
Concept Cell Nucleus
Concept Cell Division
Concept Amino Acid Isomerases
Concept Antigens, Differentiation
Concept Gene Expression
Concept COS Cells
Concept Macrophage Activation
Concept Peptide Elongation Factor 1
Concept DNA Helicases
Concept Cats
Concept Forkhead Transcription Factors
Concept RNA Interference
Concept Retinoblastoma Protein
Concept DNA, Complementary
Concept Fluorescent Antibody Technique
Concept Interleukin-15
Concept CD8-Positive T-Lymphocytes
Concept Disulfides
Concept Antigen-Antibody Complex
Concept RNA, Catalytic
Concept Carbamates
Concept Chromosomes
Concept Genes, gag
Concept HSP70 Heat-Shock Proteins
Concept Electrophoresis, Gel, Two-Dimensional
Concept Sodium-Potassium-Exchanging ATPase
Concept Endonucleases
Concept GTP-Binding Proteins
Concept Genomics
Concept Antibodies, Neutralizing
Concept Cricetinae
Concept Polyribosomes
Concept Cyclins
Concept Chromosome Banding
Concept Lysosomes
Concept Retroelements
Concept Interferons
Concept Endoplasmic Reticulum
Concept Jurkat Cells
Concept Chi-Square Distribution
Concept Genes, nef
Concept Tropism
Concept Carrier Proteins
Concept Dendritic Cells
Concept Genes
Concept DNA-(Apurinic or Apyrimidinic Site) Lyase
Concept Centrosome
Concept Reverse Transcription
Concept Africa, Western
Concept Adenosine Triphosphate
Concept Protein Biosynthesis
Concept Amino Acid Sequence
Concept Molecular Dynamics Simulation
Concept Algorithms
Concept Two-Hybrid System Techniques
Concept CDC2 Protein Kinase
Concept Cohort Studies
Concept Seasons
Concept Nuclear Envelope
Concept BCG Vaccine
Concept Boston
Concept Antineoplastic Agents
Concept Calcium
Concept Cytidine Deaminase
Concept Mycophenolic Acid
Concept Antibodies, Viral
Concept CHO Cells
Concept Blotting, Western
Concept Cancer Vaccines
Concept Cyclosporins
Concept Papillomavirus Vaccines
Concept Enhancer Elements, Genetic
Concept Genetic Predisposition to Disease
Concept Protein Interaction Domains and Motifs
Concept T-Lymphocyte Subsets
Concept Tumor Cells, Cultured
Concept Mitosis
Concept Typhoid Fever
Concept Chromatin
Concept Monomeric GTP-Binding Proteins
Concept Chromosomes, Human, Pair 7
Concept Salmonella typhi
Concept Culture Media, Serum-Free
Concept Cell Line, Transformed
Concept DNA Primers
Concept Cysteine
Concept Pseudogenes
Concept Umbilical Veins
Concept Nuclear Pore
Concept Histocytochemistry
Concept Aminocoumarins
Concept Respiratory Syncytial Virus Vaccines
Concept Transcription, Genetic
Concept HIV Envelope Protein gp120
Concept Dimerization
Concept Repressor Proteins
Concept HIV Protease
Concept Octamer Transcription Factor-3
Concept Exons
Concept rab GTP-Binding Proteins
Concept Plasma Cells
Concept Muromonab-CD3
Concept Centrifugation, Isopycnic
Concept Cell Polarity
Concept Cheirogaleidae
Concept Computational Biology
Concept Cells, Cultured
Concept Colitis, Ulcerative
Concept T Cell Transcription Factor 1
Concept Cell Separation
Concept T-Lymphocytes
Concept Hemorrhagic Fever, Ebola
Concept Calcineurin
Concept Herpesvirus 4, Human
Concept Cytoplasm
Concept Capsid
Concept Lymphocyte Culture Test, Mixed
Concept Antigens, CD
Concept Monocytes
Concept Viral Load
Concept Interleukin-2
Concept Glutathione Transferase
Concept Cell Proliferation
Concept Homeodomain Proteins
Concept CpG Islands
Concept Subtilisins
Concept Escherichia coli
Concept Ribonuclease, Pancreatic
Concept Potassium Chloride
Concept Adaptor Proteins, Signal Transducing
Concept Flavivirus Infections
Concept DEAD-box RNA Helicases
Concept Lymphocytes
Concept Zinc Fingers
Concept Vero Cells
Concept Genes, Reporter
Concept Vaccinia virus
Concept Nucleocapsid
Concept Transcription Factor AP-1
Concept Neutralization Tests
Concept Antibodies, Monoclonal
Concept Cell Membrane
Concept Crystallography, X-Ray
Concept Liver Transplantation
Concept Cluster Analysis
Concept Virology
Concept Detergents
Concept Green Fluorescent Proteins
Concept Lymphocyte Activation
Concept Cyclosporine
Concept Convalescence
Concept Endosomes
Concept Capsid Proteins
Concept Carcinoma
Concept Ribonucleases
Concept Influenza Vaccines
Concept Leukocytes, Mononuclear
Concept Colorado
Concept Interferon-alpha
Concept K562 Cells
Concept Mass Screening
Concept DNA Probes
Concept Quantitative Trait Loci
Concept Genes, Essential
Concept Carbon-Oxygen Lyases
Concept Japan
Concept Fluorescence Resonance Energy Transfer
Concept Trichloroacetic Acid
Concept CD4-Positive T-Lymphocytes
Concept Radioimmunoprecipitation Assay
Concept Vaccinia
Concept Flavivirus
Concept 3' Untranslated Regions
Concept Sequence Homology, Amino Acid
Concept Diabetes Mellitus, Type 1
Concept Thermogenesis
Concept Contact Tracing
Concept Staining and Labeling
Concept Genistein
Concept Genome-Wide Association Study
Concept Ions
Concept Proteomics
Concept HIV Antibodies
Concept Th2 Cells
Concept Embryonic Stem Cells
Concept Callithrix
Concept AIDS Vaccines
Concept Chaperonins
Concept Peptide Hydrolases
Concept Cell Line
Concept Adenosine Triphosphatases
Concept STAT1 Transcription Factor
Concept B-Lymphocytes
Concept Coronavirus Infections
Concept Buffers
Concept beta-Galactosidase
Concept DNA-Directed RNA Polymerases
Concept Peptidyl-Dipeptidase A
Concept Proteasome Endopeptidase Complex
Concept Spindle Apparatus
Concept Bayes Theorem
Concept Virion
Concept Long Interspersed Nucleotide Elements
Concept Colon
Concept In Situ Hybridization, Fluorescence
Concept Trypsin
Concept Octoxynol
Concept Epstein-Barr Virus Infections
Concept Ebolavirus
Concept Promoter Regions, Genetic
Concept HIV Envelope Protein gp41
Concept Gene Silencing
Concept Vimentin
Concept Cyclic AMP
Concept Base Sequence
Concept Alleles
Concept RNA Probes
Concept Zebrafish
Concept Oxides
Concept Killer Cells, Natural
Concept Interferon Type I
Concept Cyclophilins
Concept Cold Temperature
Concept Measles-Mumps-Rubella Vaccine
Concept Cell Line, Tumor
Concept Molecular Sequence Data
Concept Carbazoles
Concept DNA Transposable Elements
Concept SAIDS Vaccines
Concept Genes, vpr
Concept SUMO-1 Protein
Academic Article Overcoming current limitations in humanized mouse research.
Academic Article The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating.
Academic Article TRIM5a and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.
Academic Article Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA.
Academic Article Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Academic Article Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.
Academic Article Processing strategies and software solutions for data-independent acquisition in mass spectrometry.
Academic Article Optimization of human dendritic cell sample preparation for mass spectrometry-based proteomic studies.
Academic Article Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.
Academic Article The Use of Variable Q1 Isolation Windows Improves Selectivity in LC-SWATH-MS Acquisition.
Academic Article HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
Academic Article Ranking Fragment Ions Based on Outlier Detection for Improved Label-Free Quantification in Data-Independent Acquisition LC-MS/MS.
Academic Article TRIM5 Retroviral Restriction Activity Correlates with the Ability To Induce Innate Immune Signaling.
Academic Article HIV-1 capsid is involved in post-nuclear entry steps.
Academic Article Closing the net on retroviruses.
Academic Article End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data.
Academic Article Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.
Academic Article Optimization by infusion of multiple reaction monitoring transitions for sensitive quantification of peptides by liquid chromatography/mass spectrometry.
Academic Article HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon.
Academic Article The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5a.
Academic Article Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Academic Article Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines.
Academic Article Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.
Academic Article Enhanced Cas12a editing in mammalian cells and zebrafish.
Academic Article The hidden cost of genetic resistance to HIV-1.
Academic Article TRIM5a Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Academic Article Retraction Note: The hidden cost of genetic resistance to HIV-1.
Academic Article The piRNA Response to Retroviral Invasion of the Koala Genome.
Academic Article Cyclophilin A protects HIV-1 from restriction by human TRIM5a.
Academic Article Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111.
Academic Article Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics.
Academic Article Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding.
Academic Article HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells.
Academic Article TRIM34 restricts HIV-1 and SIV capsids in a TRIM5a-dependent manner.
Academic Article Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Academic Article Single-Cell RNA Profiling Reveals Adipocyte to Macrophage Signaling Sufficient to Enhance Thermogenesis.
Academic Article The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines.
Academic Article Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.
Academic Article Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Academic Article The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Academic Article Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.
Academic Article Innate lymphoid cells and disease tolerance in SARS-CoV-2 infection.
Academic Article SARS-CoV-2 Reinfection in a Liver Transplant Recipient.
Academic Article Lessons from a local effort to screen for SARS-CoV-2.
Academic Article Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis.
Academic Article Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity.
Academic Article AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
Academic Article Genome-wide functional screen of 3'UTR variants uncovers causal variants for human disease and evolution.
Academic Article Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike.
Academic Article Consulting the Oracle of SARS-CoV-2 Infection.
Concept Nanog Homeobox Protein
Concept Sequestosome-1 Protein
Concept DEAD Box Protein 58
Concept APOBEC-3G Deaminase
Concept Regulatory Factor X Transcription Factors
Concept X-Box Binding Protein 1
Concept Protein Domains
Concept Interferon-Induced Helicase, IFIH1
Concept Gene Editing
Concept Protein Conformation, alpha-Helical
Concept Intraepithelial Lymphocytes
Concept SAM Domain and HD Domain-Containing Protein 1
Concept ATPases Associated with Diverse Cellular Activities
Concept Valosin Containing Protein
Concept HEK293 Cells
Concept Single-Cell Analysis
Concept Transcriptome
Concept Asymptomatic Infections
Concept Pandemics
Concept Argonaute Proteins
Concept CTLA-4 Antigen
Concept Antibodies, Monoclonal, Humanized
Concept Primary Cell Culture
Concept Sf9 Cells
Concept Calcineurin Inhibitors
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept CRISPR-Cas Systems
Concept Fatty Acid Synthases
Concept Myxovirus Resistance Proteins
Concept Amphiregulin
Academic Article Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness.
Academic Article Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses.
Academic Article Innate lymphoid cells and COVID-19 severity in SARS-CoV-2 infection.
Academic Article Conformational dynamics and allosteric modulation of the SARS-CoV-2 spike.
Academic Article Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness.
Academic Article Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant.
Academic Article The 2022 RSV surge was driven by multiple viral lineages.
Academic Article Multimodal surveillance of SARS-CoV-2 at a university enables development of a robust outbreak response framework.
Academic Article Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome.
Academic Article Purification and structure of luminal domain C of human Niemann-Pick C1 protein.
Academic Article Viral Lineages in the 2022 RSV Surge in the United States.
Academic Article S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness.
Academic Article Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination.
Academic Article Transcriptional and chromatin profiling of human blood innate lymphoid cell subsets sheds light on HIV-1 pathogenesis.
Academic Article Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency.
Academic Article The HIV-1 capsid core is an opportunistic nuclear import receptor.
Academic Article Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15.
Academic Article Emerging role of cyclophilin A in HIV-1 infection: from producer cell to the target cell nucleus.
Academic Article Addressing the dNTP bottleneck restricting prime editing activity.
Academic Article Cytotoxic CD4 development requires CD4 effectors to concurrently recognize local antigen and encounter type I IFN-induced IL-15.
Academic Article Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome.
Academic Article IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Academic Article Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses.
Academic Article Optimization of Nuclear Localization Signal Composition Improves CRISPR-Cas12a Editing Rates in Human Primary Cells.
Academic Article Cyclophilin A Facilitates HIV-1 DNA Integration.
Academic Article IFIH1 (MDA5) is required for innate immune detection of intron-containing RNA expressed from the HIV-1 provirus.
Academic Article PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing.
Academic Article Increasing intracellular dNTP levels improves prime editing efficiency.
Academic Article Cyclophilin A facilitates HIV-1 integration.
Academic Article piRNA Defense Against Endogenous Retroviruses.
Academic Article The Trajectory of KoRV-A Evolution Indicates Initial Integration into the Koala Germline Genome Near Coffs Harbour.
Academic Article Correction for Kajaste-Rudnitski et al., "TRIM22 Inhibits HIV-1 Transcription Independently of Its E3 Ubiquitin Ligase Activity, Tat, and NF-?B-Responsive Long Terminal Repeat Elements".
Academic Article Molecular basis for the increased fusion activity of the Ebola virus glycoprotein epidemic variant A82V: Insights from simulations and experiments.
Academic Article Evolution of KoRV-A transcriptional silencing in wild koalas.
Academic Article Computationally designed proteins mimic antibody immune evasion in viral evolution.
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