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Luban, Jeremy

One or more keywords matched the following properties of Luban, Jeremy

Property	Value
overview	Please visit the Luban Lab Website Professor Luban is a physician-scientist who studies the interaction between human cells and deadly pathogens including HIV-1, Ebola virus, and SARS-CoV-2. He has held endowed professorships at Columbia University in New York (where he directed the Columbia-Rockefeller Center for AIDS Research), the University of Geneva in Switzerland, and now the University of Massachusetts Medical School, where he holds the David J. Freelander Chair in AIDS Research. He is an affiliate of the Broad Institute of MIT and Harvard and oversees a program on SARS-CoV-2 as part of the Massachusetts Consortium on Pathogen Readiness. Dr. Luban was elected to the American Society for Clinical Investigation, the Association of American Physicians, and the American Academy of Microbiology. His research program in Virology, Immunology, and Molecular Biology has been continuously funded for the past 30 years by the National Institute of Health and includes Merit and Avant Garde Awards. He has served on editorial boards of four virology journals, on grant review committees and scientific advisory boards for the NIH, the American Cancer Society, the American Foundation for AIDS Research, and has acted as primary mentor for 90 Ph.D. students, post-docs, and undergraduate students.

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overview

Please visit the Luban Lab Website

Professor Luban is a physician-scientist who studies the interaction between human cells and deadly pathogens including HIV-1, Ebola virus, and SARS-CoV-2. He has held endowed professorships at Columbia University in New York (where he directed the Columbia-Rockefeller Center for AIDS Research), the University of Geneva in Switzerland, and now the University of Massachusetts Medical School, where he holds the David J. Freelander Chair in AIDS Research. He is an affiliate of the Broad Institute of MIT and Harvard and oversees a program on SARS-CoV-2 as part of the Massachusetts Consortium on Pathogen Readiness. Dr. Luban was elected to the American Society for Clinical Investigation, the Association of American Physicians, and the American Academy of Microbiology. His research program in Virology, Immunology, and Molecular Biology has been continuously funded for the past 30 years by the National Institute of Health and includes Merit and Avant Garde Awards. He has served on editorial boards of four virology journals, on grant review committees and scientific advisory boards for the NIH, the American Cancer Society, the American Foundation for AIDS Research, and has acted as primary mentor for 90 Ph.D. students, post-docs, and undergraduate students.

One or more keywords matched the following items that are connected to Luban, Jeremy

Item Type	Name
Academic Article	Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.
Academic Article	Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.
Academic Article	Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription.
Academic Article	The HIV type 1 replication block in nonhuman primates is not explained by differences in cyclophilin A primary structure.
Academic Article	Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses.
Academic Article	Translation elongation factor 1-alpha interacts specifically with the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article	Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.
Academic Article	Rescue of multiple viral functions by a second-site suppressor of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article	Inhibition of HIV-1 replication by cyclosporine A or related compounds correlates with the ability to disrupt the Gag-cyclophilin A interaction.
Academic Article	Human immunodeficiency virus type 1 virion density is not determined by nucleocapsid basic residues.
Academic Article	Absconding with the chaperone: essential cyclophilin-Gag interaction in HIV-1 virions.
Academic Article	The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
Academic Article	Context-dependent phenotype of a human immunodeficiency virus type 1 nucleocapsid mutation.
Academic Article	Genetic assay for multimerization of retroviral gag polyproteins.
Academic Article	HIV-1 Vpr: G2 cell cycle arrest, macrophages and nuclear transport.
Academic Article	Specific incorporation of heat shock protein 70 family members into primate lentiviral virions.
Academic Article	Human immunodeficiency virus type 1 replication is modulated by host cyclophilin A expression levels.
Academic Article	As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity.
Academic Article	Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
Academic Article	Lv1 inhibition of human immunodeficiency virus type 1 is counteracted by factors that stimulate synthesis or nuclear translocation of viral cDNA.
Academic Article	Target cell cyclophilin A modulates human immunodeficiency virus type 1 infectivity.
Academic Article	Human immunodeficiency virus type 1 Gag polyprotein multimerization requires the nucleocapsid domain and RNA and is promoted by the capsid-dimer interface and the basic region of matrix protein.
Academic Article	Disruption of human TRIM5alpha antiviral activity by nonhuman primate orthologues.
Academic Article	Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein.
Academic Article	Cyclophilin A regulates HIV-1 infectivity, as demonstrated by gene targeting in human T cells.
Academic Article	Vif counteracts a cyclophilin A-imposed inhibition of simian immunodeficiency viruses in human cells.
Academic Article	HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase.
Academic Article	Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells.
Academic Article	An invariant surface patch on the TRIM5alpha PRYSPRY domain is required for retroviral restriction but dispensable for capsid binding.
Academic Article	The double-stranded RNA binding domain of the vaccinia virus E3L protein inhibits both RNA- and DNA-induced activation of interferon beta.
Academic Article	Human cellular restriction factors that target HIV-1 replication.
Academic Article	HIV-1 and Ebola virus: the getaway driver nabbed.
Academic Article	Cyclosporine blocks incorporation of HIV-1 envelope glycoprotein into virions.
Academic Article	Deciphering the code for retroviral integration target site selection.
Academic Article	TRIM22 inhibits HIV-1 transcription independently of its E3 ubiquitin ligase activity, Tat, and NF-kappaB-responsive long terminal repeat elements.
Academic Article	Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.
Academic Article	Envelope-dependent, cyclophilin-independent effects of glycosaminoglycans on human immunodeficiency virus type 1 attachment and infection.
Academic Article	TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.
Academic Article	The carboxyl-terminus of human immunodeficiency virus type 2 circulating recombinant form 01_AB capsid protein affects sensitivity to human TRIM5a.
Academic Article	TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.
Academic Article	Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein.
Academic Article	Selection for loss of Ref1 activity in human cells releases human immunodeficiency virus type 1 from cyclophilin A dependence during infection.
Academic Article	Covalent modification of human immunodeficiency virus type 1 p6 by SUMO-1.
Academic Article	ATPgammaS disrupts human immunodeficiency virus type 1 virion core integrity.
Academic Article	Arsenic counteracts human immunodeficiency virus type 1 restriction by various TRIM5 orthologues in a cell type-dependent manner.
Academic Article	Cyclophilin A and TRIM5alpha independently regulate human immunodeficiency virus type 1 infectivity in human cells.
Academic Article	Cyclophilin, TRIM5, and innate immunity to HIV-1.
Academic Article	Cyclophilin A, TRIM5, and resistance to human immunodeficiency virus type 1 infection.
Academic Article	The role of lysine 186 in HIV-1 integrase multimerization.
Academic Article	Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics.
Academic Article	HIV-1 Vpu neutralizes the antiviral factor Tetherin/BST-2 by binding it and directing its beta-TrCP2-dependent degradation.
Academic Article	Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41.
Academic Article	Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay.
Academic Article	Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B.
Academic Article	Cyclophilin binding to the human immunodeficiency virus type 1 Gag polyprotein is mimicked by an anti-cyclosporine antibody.
Academic Article	Cyclophilin and gag in HIV-1 replication and pathogenesis.
Academic Article	Linker insertion mutations in the human immunodeficiency virus type 1 gag gene: effects on virion particle assembly, release, and infectivity.
Academic Article	Specific incorporation of cyclophilin A into HIV-1 virions.
Academic Article	Mutational analysis of cis-acting packaging signals in human immunodeficiency virus type 1 RNA.
Academic Article	Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid protein to viral RNAs detected by RNA mobility shift assays.
Academic Article	Effect of linker insertion mutations in the human immunodeficiency virus type 1 gag gene on activation of viral protease expressed in bacteria.
Academic Article	Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.
Concept	rev Gene Products, Human Immunodeficiency Virus
Concept	Viruses
Concept	Virus Release
Concept	Virus Integration
Concept	Virus Replication
Concept	Respiratory Syncytial Viruses
Concept	Human Immunodeficiency Virus Proteins
Concept	Virus Internalization
Concept	vpr Gene Products, Human Immunodeficiency Virus
Concept	Respiratory Syncytial Virus Vaccines
Concept	Infectious Anemia Virus, Equine
Concept	Herpesvirus 4, Human
Concept	Receptors, Virus
Concept	Tumor Virus Infections
Concept	Reassortant Viruses
Concept	Simian Immunodeficiency Virus
Concept	Moloney murine leukemia virus
Concept	Mason-Pfizer monkey virus
Concept	gag Gene Products, Human Immunodeficiency Virus
Concept	Vaccinia virus
Concept	Virus Assembly
Concept	Respiratory Syncytial Virus Infections
Concept	nef Gene Products, Human Immunodeficiency Virus
Concept	Leukemia Virus, Murine
Concept	env Gene Products, Human Immunodeficiency Virus
Concept	Epstein-Barr Virus Infections
Concept	vif Gene Products, Human Immunodeficiency Virus
Academic Article	Overcoming current limitations in humanized mouse research.
Academic Article	The fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoating.
Academic Article	TRIM5a and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.
Academic Article	Cyclophilin A promotes HIV-1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA.
Academic Article	Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.
Academic Article	Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIVMAC/SIVSM/HIV-2 Lineage Prior to Integration.
Academic Article	HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
Academic Article	HIV-1 capsid is involved in post-nuclear entry steps.
Academic Article	Ebola Virus Glycoprotein with Increased Infectivity Dominated the 2013-2016 Epidemic.
Academic Article	HIV-1 R5 Macrophage-Tropic Envelope Glycoprotein Trimers Bind CD4 with High Affinity, while the CD4 Binding Site on Non-macrophage-tropic, T-Tropic R5 Envelopes Is Occluded.
Academic Article	Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex.
Academic Article	Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines.
Academic Article	TRIM5a Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation.
Academic Article	Cyclophilin A protects HIV-1 from restriction by human TRIM5a.
Academic Article	Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111.
Academic Article	Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics.
Academic Article	Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding.
Academic Article	TRIM34 restricts HIV-1 and SIV capsids in a TRIM5a-dependent manner.
Academic Article	Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Academic Article	The DHODH inhibitor PTC299 arrests SARS-CoV-2 replication and suppresses induction of inflammatory cytokines.
Academic Article	Influence of Different Glycoproteins and of the Virion Core on SERINC5 Antiviral Activity.
Concept	Virus Uncoating
Academic Article	Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant.
Academic Article	Viral Lineages in the 2022 RSV Surge in the United States.
Academic Article	Regulation of Ebola GP conformation and membrane binding by the chemical environment of the late endosome.
Academic Article	Natural history of Ebola virus disease in rhesus monkeys shows viral variant emergence dynamics and tissue-specific host responses.
Academic Article	Cyclophilin A facilitates HIV-1 integration.
Academic Article	piRNA Defense Against Endogenous Retroviruses.

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