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  Circadian and Circatidal Rhythms 

Our environment is constantly changing.  The Sun rises and sets every day, causing rhythmic changes in light and temperature.  At most latitudes, weather and day length vary as seasons pass.  On the coastline, tides rise and fall.  Because these environmental cycles occur with precise periodicities, most organisms on Earth have acquired biological clocks that can track and predict them.  Organisms can thus adapt and anticipate changes in light intensity, temperature, day length or water level by adjusting their physiology and behavior in a time-dependent manner.  

Circadian clocks have a period of 24 hours and synchronize to daily environmental cycles.  They regulate complex behaviors such as the sleep/wake cycle, as well as metabolism and physiology throughout our body. Their disruption - for instance due to shift work - can have serious detrimental health consequences. Circatidal clocks are found in coastal organisms.  They have a period of 12.4 hours and synchronize to tides. Our lab’s overall objective is to elucidate basic molecular and neural mechanisms that underlie circadian and circatidal rhythms, and to understand how biological clocks allow for behavioral adaptations to environmental cycles.  Most of our work is performed in Drosophila melanogaster, a fantastic model organism to study the fundamental mechanisms underlying circadian rhythms and one of its critical outputs: sleep.  We have also recently started to use Parhyale hawaiensis, a genetically-tractable crustacean, to study circatidal clocks, the mechanisms of which are very poorly understood.

For more information, please visit our lab page at:  https://www.umassmed.edu/emerylab/

One or more keywords matched the following items that are connected to Emery, Patrick
Item TypeName
Academic Article The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila.
Academic Article A unique circadian-rhythm photoreceptor.
Academic Article Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter.
Academic Article Stopping time: the genetics of fly and mouse circadian clocks.
Academic Article A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses.
Academic Article Light and temperature control the contribution of specific DN1 neurons to Drosophila circadian behavior.
Academic Article A role for Drosophila ATX2 in activation of PER translation and circadian behavior.
Academic Article Drosophila clock can generate ectopic circadian clocks.
Academic Article Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception.
Academic Article Ectopic CRYPTOCHROME renders TIM light sensitive in the Drosophila ovary.
Concept Drosophila melanogaster
Academic Article Studying circadian rhythms in Drosophila melanogaster.
Academic Article miR-124 Regulates the Phase of Drosophila Circadian Locomotor Behavior.
Academic Article SIK3-HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons.
Academic Article Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock.
Academic Article Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing.
Academic Article Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster.
Academic Article Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons.
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  • Drosophila melanogaster