| Item Type | Name |
|
Academic Article
|
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
|
|
Academic Article
|
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
|
|
Academic Article
|
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
|
|
Academic Article
|
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
|
|
Academic Article
|
The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
|
|
Academic Article
|
Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
|
|
Academic Article
|
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
|
|
Academic Article
|
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
|
|
Academic Article
|
The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
|
|
Academic Article
|
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
|
|
Academic Article
|
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
|
|
Academic Article
|
Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
|
|
Academic Article
|
An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
|
|
Academic Article
|
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
|
|
Academic Article
|
IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
|
|
Academic Article
|
Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
|
|
Academic Article
|
Catenin' on to nucleic acid sensing.
|
|
Academic Article
|
Inflammasomes and anti-viral immunity.
|
|
Academic Article
|
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
|
|
Academic Article
|
A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
|
|
Academic Article
|
Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
|
|
Academic Article
|
Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
|
|
Academic Article
|
Immunology. Select inflammasome assembly.
|
|
Academic Article
|
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
|
|
Academic Article
|
Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
|
|
Academic Article
|
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
|
|
Academic Article
|
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
|
|
Academic Article
|
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
|
|
Academic Article
|
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
|
|
Academic Article
|
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
|
|
Academic Article
|
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
|
|
Academic Article
|
Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
|
|
Academic Article
|
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
|
|
Academic Article
|
Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
|
|
Academic Article
|
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
|
|
Academic Article
|
Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.
|
|
Academic Article
|
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
|
|
Academic Article
|
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
|
|
Academic Article
|
Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
|
|
Academic Article
|
Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
|
|
Academic Article
|
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
|
|
Academic Article
|
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
|
|
Academic Article
|
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
|
|
Academic Article
|
Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
|
|
Academic Article
|
Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
|
|
Academic Article
|
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
|
|
Academic Article
|
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
|
|
Academic Article
|
Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
|
|
Academic Article
|
Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
|
|
Academic Article
|
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
|
|
Academic Article
|
NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
|
|
Concept
|
Protein Binding
|
|
Concept
|
DNA-Binding Proteins
|
|
Concept
|
Phosphate-Binding Proteins
|
|
Concept
|
Periplasmic Binding Proteins
|
|
Concept
|
ral GTP-Binding Proteins
|
|
Concept
|
GTP-Binding Proteins
|
|
Concept
|
Carrier Proteins
|
|
Concept
|
rab GTP-Binding Proteins
|
|
Concept
|
CCAAT-Enhancer-Binding Protein-beta
|
|
Concept
|
Membrane Transport Proteins
|
|
Concept
|
Calcium-Binding Proteins
|
|
Concept
|
CCAAT-Enhancer-Binding Proteins
|
|
Concept
|
RNA-Binding Proteins
|
|
Academic Article
|
Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
|
|
Academic Article
|
Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system.
|
|
Academic Article
|
Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
|
|
Academic Article
|
Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
|
|
Academic Article
|
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
|
|
Academic Article
|
Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
|
|
Academic Article
|
Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
|
|
Academic Article
|
Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
|
|
Academic Article
|
Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
|
|
Academic Article
|
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
|
|
Academic Article
|
NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
|
|
Academic Article
|
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.
|
|
Academic Article
|
Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
|
|
Academic Article
|
TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
|
|
Academic Article
|
RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
|
|
Academic Article
|
TRIL is involved in cytokine production in the brain following Escherichia coli infection.
|
|
Academic Article
|
Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans.
|
|
Academic Article
|
IKK? negatively regulates ASC-dependent inflammasome activation.
|
|
Academic Article
|
Identification of Aim2 as a sensor for DNA vaccines.
|
|
Academic Article
|
Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
|
|
Academic Article
|
GBPs take AIM at Francisella.
|
|
Academic Article
|
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
|
|
Academic Article
|
Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
|
|
Academic Article
|
Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
|
|
Academic Article
|
An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
|
|
Academic Article
|
Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
|
|
Academic Article
|
Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
|
|
Academic Article
|
Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
|
|
Academic Article
|
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
|
|
Academic Article
|
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
|
|
Academic Article
|
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
|
|
Academic Article
|
CNBP controls IL-12 gene transcription and Th1 immunity.
|
|
Academic Article
|
Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
|
|
Academic Article
|
Gasdermins and their role in immunity and inflammation.
|
|
Academic Article
|
Long non-coding RNAs in antiviral immunity.
|
|
Academic Article
|
Succination inactivates gasdermin D and blocks pyroptosis.
|
|
Academic Article
|
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
|
|
Academic Article
|
Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
|
|
Academic Article
|
AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
|