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Search Results to Katherine A Fitzgerald PhD

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One or more keywords matched the following properties of Fitzgerald, Katherine

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Biography

Kate Fitzgerald received her B.Sc. in 1995 from University College Cork, Ireland, and her Ph.D. in 1999 from Trinity College Dublin, Ireland. From 1999 to 2001, she was a post-doctoral fellow in the Department of Biochemistry at Trinity College Dublin in the Laboratory of Professor Luke O'Neill. Dr. Fitzgerald joined the Division of Infectious Disease at the University of Massachusetts Medical School as a recipient of a Welcome Trust International Award in 2001. In 2004 she joined the Faculty as an Assistant Professor and is currently Professor of Medicine and Director of the Program in Innate Immunity (www.umassmed.edu/pii).

Research Information  Katherine Photo

INNATE IMMUNE SIGNALING

Research in the Fitzgerald lab is focused on understanding the molecular basis of host defense and the inflammatory process. Active research areas include: (1) mechanisms and biology of caspase-1 activating inflammasome complexes, (2) nucleic acid sensors, with a particular focus on cytosolic DNA recognition systems and (3) role of long non-coding RNAs (lincRNAs) in the regulation of inflammatory gene expression. Enabling these studies, our research uses immunology, molecular biology, biochemistry and genetics to understand these mechanisms. Our longer term goals are to understand how dysregulation of sensing, signaling and gene regulation in innate immunity underlie the pathogenesis of infectious, inflammatory and autoimmune disease in humans.


One or more keywords matched the following items that are connected to Fitzgerald, Katherine

Item TypeName
Academic Article An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
Academic Article Inflammasomes and anti-viral immunity.
Academic Article TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Academic Article The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Academic Article Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Academic Article NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Academic Article Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Academic Article NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1ß and neuronal toxicity.
Academic Article Cutting edge: FAS (CD95) mediates noncanonical IL-1ß and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Concept Caspase 8
Concept Caspase 1
Concept Caspase 2
Academic Article Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1ß production.
Academic Article Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Academic Article Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
Academic Article Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans.
Academic Article Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Academic Article Mechanisms of inflammasome activation: recent advances and novel insights.
Academic Article Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
Academic Article The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
Academic Article Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Academic Article A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1ß Release in Response to a Pathogenic Fungus.

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