| Item Type | Name |
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Academic Article
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
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Academic Article
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Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
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Academic Article
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
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Academic Article
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DUBbing down innate immunity.
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Academic Article
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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
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Academic Article
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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
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Academic Article
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The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence.
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Academic Article
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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
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Academic Article
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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
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Academic Article
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Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
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Academic Article
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Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
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Academic Article
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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
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Academic Article
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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
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Academic Article
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Academic Article
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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
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Academic Article
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
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Academic Article
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NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
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Academic Article
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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
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Academic Article
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IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
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Academic Article
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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
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Academic Article
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Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).
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Academic Article
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Catenin' on to nucleic acid sensing.
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Academic Article
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Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
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Academic Article
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
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Academic Article
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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.
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Academic Article
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Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
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Academic Article
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Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
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Academic Article
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Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
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Academic Article
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Sorting out Toll signals.
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Academic Article
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Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
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Academic Article
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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Academic Article
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Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
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Academic Article
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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
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Academic Article
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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
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Academic Article
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Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
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Academic Article
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Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
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Academic Article
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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
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Academic Article
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Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
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Academic Article
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
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Academic Article
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Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
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Academic Article
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Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
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Academic Article
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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
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Academic Article
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Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
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Academic Article
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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
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Concept
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Hepatocyte Nuclear Factor 4
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Concept
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TNF Receptor-Associated Factor 6
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Concept
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Transcription Factor CHOP
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Concept
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Transcription Factor RelB
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Concept
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TNF Receptor-Associated Factor 2
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Concept
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Receptor Activator of Nuclear Factor-kappa B
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Concept
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GATA6 Transcription Factor
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Concept
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Myeloid Differentiation Factor 88
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Concept
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Interferon-Stimulated Gene Factor 3
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Concept
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Interferon Regulatory Factor-7
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Concept
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Microphthalmia-Associated Transcription Factor
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Concept
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STAT3 Transcription Factor
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Concept
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Activating Transcription Factor 3
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Concept
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Receptors, Tumor Necrosis Factor, Type II
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Concept
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Tumor Necrosis Factor-alpha
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Concept
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Granulocyte-Macrophage Colony-Stimulating Factor
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Concept
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Interferon Regulatory Factor-3
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Concept
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Interferon Regulatory Factor-1
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Concept
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Transcription Factor AP-1
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Concept
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Receptors, Tumor Necrosis Factor, Type I
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Concept
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STAT6 Transcription Factor
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Concept
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STAT1 Transcription Factor
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Concept
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Activating Transcription Factor 4
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Concept
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Receptors, Tumor Necrosis Factor
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Concept
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Transcription Factor RelA
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Academic Article
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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
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Academic Article
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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
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Academic Article
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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
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Academic Article
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
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Academic Article
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Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
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Academic Article
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TRIL is involved in cytokine production in the brain following Escherichia coli infection.
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Academic Article
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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
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Academic Article
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
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Academic Article
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Suppression of systemic autoimmunity by the innate immune adaptor STING.
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Academic Article
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GBPs take AIM at Francisella.
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Academic Article
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Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
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Academic Article
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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
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Academic Article
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
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Academic Article
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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
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Academic Article
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Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
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Academic Article
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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
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Academic Article
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IRF3 and type I interferons fuel a fatal response to myocardial infarction.
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Academic Article
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Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
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Academic Article
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Immature lung TNFR2- conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
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Academic Article
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Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
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Concept
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Regulatory Factor X Transcription Factors
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Concept
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Tumor Necrosis Factor alpha-Induced Protein 3
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Concept
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Positive Regulatory Domain I-Binding Factor 1
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Academic Article
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Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum.
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Academic Article
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Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
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Academic Article
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Gene coexpression networks reveal a broad role for lncRNAs in inflammatory bowel disease.
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Academic Article
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.
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