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Inflammasomes and anti-viral immunity.
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
The NLRP12 inflammasome recognizes Yersinia pestis.
Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Identification of Aim2 as a sensor for DNA vaccines.
Mechanisms of inflammasome activation: recent advances and novel insights.
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
Igniting the firestorm: The inflammasome in autoinflammatory syndromes.