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Academic Article
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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
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Academic Article
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
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Academic Article
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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
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Academic Article
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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
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Academic Article
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Academic Article
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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
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Academic Article
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An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
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Academic Article
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NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
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Academic Article
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Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
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Academic Article
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Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
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Academic Article
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Academic Article
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Immunology. Select inflammasome assembly.
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Academic Article
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
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Academic Article
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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
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Academic Article
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A long noncoding RNA mediates both activation and repression of immune response genes.
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Academic Article
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Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
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Academic Article
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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
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Academic Article
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Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
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Academic Article
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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
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Academic Article
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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
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Academic Article
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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Academic Article
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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
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Academic Article
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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
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Academic Article
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
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Academic Article
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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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Academic Article
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Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
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Academic Article
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Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
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Academic Article
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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
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Academic Article
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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
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Academic Article
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Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
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Academic Article
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Defective pro-IL-1? responses in macrophages from aged mice.
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Academic Article
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RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
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Academic Article
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Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
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Academic Article
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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
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Concept
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Macrophages, Alveolar
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Concept
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Macrophage Activation
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Concept
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Macrophages
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Concept
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Granulocyte-Macrophage Colony-Stimulating Factor
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Concept
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Macrophages, Peritoneal
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Concept
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Macrophage-1 Antigen
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Academic Article
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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
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Academic Article
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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
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Academic Article
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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
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Academic Article
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Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
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Academic Article
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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
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Academic Article
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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
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Academic Article
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RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
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Academic Article
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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans.
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Academic Article
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IKKa negatively regulates ASC-dependent inflammasome activation.
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Academic Article
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Innate sensing of malaria parasites.
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Academic Article
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
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Academic Article
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Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
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Academic Article
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Cutting Edge: A Natural Antisense Transcript, AS-IL1a, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1a.
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Academic Article
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
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Academic Article
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Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
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Academic Article
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Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
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Academic Article
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A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
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Academic Article
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Control of the innate immune response by the mevalonate pathway.
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Academic Article
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
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Academic Article
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Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-? Synthesis Induced by Lipopolysaccharide.
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Academic Article
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A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
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Academic Article
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Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
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Academic Article
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
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Academic Article
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A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
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Academic Article
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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
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Academic Article
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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
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Academic Article
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Succination inactivates gasdermin D and blocks pyroptosis.
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Academic Article
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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
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Academic Article
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Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
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Academic Article
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
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Academic Article
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A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation.
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Academic Article
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.
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Academic Article
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Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
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