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Item TypeName
Academic Article Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Academic Article DUBbing down innate immunity.
Academic Article The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
Academic Article TOLLing away in Brazil.
Academic Article Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Academic Article Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Academic Article Immunology. The shape of things to come.
Academic Article Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Academic Article Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
Academic Article Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
Academic Article A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Academic Article TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
Academic Article Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Academic Article Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Academic Article An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
Academic Article NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
Academic Article Integr-ating IL-1 alpha in antiviral host defenses.
Academic Article A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Academic Article Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
Academic Article Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).
Academic Article TLR4 is a negative regulator in noninfectious lung inflammation.
Academic Article Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
Academic Article Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
Academic Article Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Academic Article A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
Academic Article Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
Academic Article Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Academic Article DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Academic Article Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
Academic Article TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
Academic Article Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
Academic Article Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
Academic Article The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Academic Article Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Academic Article CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article A long noncoding RNA mediates both activation and repression of immune response genes.
Academic Article LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Academic Article TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
Academic Article The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
Academic Article Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
Academic Article Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
Academic Article The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Academic Article Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
Academic Article Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
Academic Article Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
Academic Article The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
Academic Article AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Academic Article Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Academic Article Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Academic Article Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
Academic Article The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
Academic Article NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
Academic Article Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
Academic Article Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
Academic Article Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Academic Article Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Academic Article Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Academic Article Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
Academic Article Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
Academic Article Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Academic Article Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
Academic Article Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
Academic Article Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
Academic Article The NLRP12 inflammasome recognizes Yersinia pestis.
Academic Article NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
Academic Article 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
Academic Article Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
Academic Article Defective pro-IL-1? responses in macrophages from aged mice.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Academic Article RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
Academic Article Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Academic Article Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Academic Article Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Academic Article Immunology: Lipopolysaccharide sensing on the inside.
Concept Mice, Inbred BALB C
Concept Mice, Knockout
Concept Mice, Inbred C3H
Concept Mice
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Concept Mice, Mutant Strains
Academic Article The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
Academic Article Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
Academic Article Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system.
Academic Article Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
Academic Article Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
Academic Article STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
Academic Article Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
Academic Article Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
Academic Article Recognition of cytosolic DNA by cGAS and other STING-dependent sensors.
Academic Article Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Academic Article Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals.
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article TRIF signaling is essential for TLR4-driven IgE class switching.
Academic Article NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
Academic Article Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
Academic Article Post-transcriptional regulation of gene expression in innate immunity.
Academic Article Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
Academic Article TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
Academic Article RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
Academic Article TRIL is involved in cytokine production in the brain following Escherichia coli infection.
Academic Article Citrobacter rodentium: infection, inflammation and the microbiota.
Academic Article Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans.
Academic Article IKKa negatively regulates ASC-dependent inflammasome activation.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Identification of Aim2 as a sensor for DNA vaccines.
Academic Article Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
Academic Article A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
Academic Article Suppression of systemic autoimmunity by the innate immune adaptor STING.
Academic Article Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
Academic Article GBPs take AIM at Francisella.
Academic Article Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Academic Article Mechanisms of inflammasome activation: recent advances and novel insights.
Academic Article Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
Academic Article Cutting Edge: A Natural Antisense Transcript, AS-IL1a, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1a.
Academic Article Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
Academic Article An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
Academic Article Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
Academic Article Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
Academic Article Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
Academic Article A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
Academic Article Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Academic Article Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
Academic Article The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
Academic Article A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Academic Article A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article Control of the innate immune response by the mevalonate pathway.
Academic Article Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.
Academic Article Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
Academic Article miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Academic Article Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-? Synthesis Induced by Lipopolysaccharide.
Academic Article The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
Academic Article IRF3 and type I interferons fuel a fatal response to myocardial infarction.
Academic Article Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
Academic Article Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
Academic Article Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
Academic Article The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Academic Article Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Academic Article A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
Academic Article Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
Academic Article CNBP controls IL-12 gene transcription and Th1 immunity.
Academic Article Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
Academic Article Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
Academic Article Immature lung TNFR2- conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.
Academic Article cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Academic Article HiChIRP reveals RNA-associated chromosome conformation.
Academic Article Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome.
Academic Article A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3 Inflammasome.
Academic Article Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
Academic Article Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
Academic Article STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
Academic Article TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
Academic Article Succination inactivates gasdermin D and blocks pyroptosis.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
Academic Article Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
Academic Article The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Academic Article cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
Academic Article Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Academic Article Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
Academic Article AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
Academic Article A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation.
Concept Mice, 129 Strain
Academic Article Intracellular Sensing of DNA in Autoinflammation and Autoimmunity.
Academic Article Radioresistant cells initiate lymphocyte-dependent lung inflammation and IFN?-dependent mortality in STING gain-of-function mice.
Academic Article Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
Academic Article Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2.
Academic Article Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression.
Academic Article Mucosal nanobody IgA as inhalable and affordable prophylactic and therapeutic treatment against SARS-CoV-2 and emerging variants.
Academic Article Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Academic Article STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.
Academic Article The lncRNA HOXA11os regulates mitochondrial function in myeloid cells to maintain intestinal homeostasis.
Academic Article Targeting STING oligomerization with small-molecule inhibitors.
Academic Article Cellular nucleic acid-binding protein restricts SARS-CoV-2 by regulating interferon and disrupting RNA-protein condensates.
Academic Article The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
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