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Academic Article
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Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
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Academic Article
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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
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Academic Article
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Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
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Academic Article
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
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Academic Article
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Academic Article
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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
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Academic Article
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An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.
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Academic Article
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NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis.
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Academic Article
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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
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Academic Article
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TLR4 is a negative regulator in noninfectious lung inflammation.
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Academic Article
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Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
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Academic Article
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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
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Academic Article
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Academic Article
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article
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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
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Academic Article
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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
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Academic Article
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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
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Academic Article
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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
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Academic Article
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Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
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Academic Article
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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
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Academic Article
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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
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Academic Article
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Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
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Academic Article
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Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome.
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Academic Article
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
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Academic Article
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.
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Academic Article
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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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Academic Article
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Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
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Academic Article
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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
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Academic Article
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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
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Academic Article
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Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
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Academic Article
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Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
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Academic Article
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Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
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Academic Article
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Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
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Academic Article
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The NLRP12 inflammasome recognizes Yersinia pestis.
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Academic Article
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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
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Academic Article
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Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
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Academic Article
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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
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Academic Article
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RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
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Academic Article
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Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
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Concept
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Mice, Inbred BALB C
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Concept
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Mice, Inbred C3H
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Concept
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Mice, Inbred C57BL
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Academic Article
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Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.
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Academic Article
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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
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Academic Article
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Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
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Academic Article
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Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
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Academic Article
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
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Academic Article
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Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
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Academic Article
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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
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Academic Article
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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
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Academic Article
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TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
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Academic Article
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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
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Academic Article
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TRIL is involved in cytokine production in the brain following Escherichia coli infection.
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Academic Article
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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
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Academic Article
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Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
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Academic Article
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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
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Academic Article
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
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Academic Article
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Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
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Academic Article
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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
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Academic Article
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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
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Academic Article
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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
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Academic Article
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Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
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Academic Article
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Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
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Academic Article
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A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
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Academic Article
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A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
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Academic Article
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Control of the innate immune response by the mevalonate pathway.
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Academic Article
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Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.
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Academic Article
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Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
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Academic Article
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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
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Academic Article
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IRF3 and type I interferons fuel a fatal response to myocardial infarction.
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Academic Article
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Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
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Academic Article
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Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
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Academic Article
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A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1? Release in Response to a Pathogenic Fungus.
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Academic Article
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Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
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Academic Article
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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
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Academic Article
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Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome.
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Academic Article
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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
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Academic Article
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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
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Academic Article
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Succination inactivates gasdermin D and blocks pyroptosis.
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Academic Article
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Caspase-8 mediates inflammation and disease in rodent malaria.
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Academic Article
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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation.
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Academic Article
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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
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Academic Article
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Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
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Academic Article
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AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
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Academic Article
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A genetic screen in macrophages identifies new regulators of IFN?-inducible MHCII that contribute to T cell activation.
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Academic Article
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Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
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Academic Article
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STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.
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Academic Article
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Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration.
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Academic Article
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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer.
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Academic Article
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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
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Academic Article
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A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control.
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