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Academic Article
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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
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Academic Article
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Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
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Academic Article
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Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens.
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Academic Article
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A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
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Academic Article
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Academic Article
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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
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Academic Article
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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
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Academic Article
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TLR4 is a negative regulator in noninfectious lung inflammation.
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Academic Article
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Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
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Academic Article
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Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus.
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Academic Article
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A novel role for the NLRC4 inflammasome in mucosal defenses against the fungal pathogen Candida albicans.
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Academic Article
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Academic Article
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
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Academic Article
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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
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Academic Article
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The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
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Academic Article
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Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
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Academic Article
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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
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Academic Article
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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.
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Academic Article
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Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
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Academic Article
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Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
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Academic Article
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Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection.
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Academic Article
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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
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Academic Article
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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Academic Article
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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
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Academic Article
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Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
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Academic Article
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
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Academic Article
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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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Academic Article
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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
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Academic Article
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Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
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Academic Article
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Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
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Academic Article
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Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
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Academic Article
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
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Academic Article
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Myxoma virus induces type I interferon production in murine plasmacytoid dendritic cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-dependent pathway.
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Academic Article
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Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
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Academic Article
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The NLRP12 inflammasome recognizes Yersinia pestis.
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Academic Article
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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
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Academic Article
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Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
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Academic Article
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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
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Academic Article
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RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
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Academic Article
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Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
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Concept
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Mice, Knockout
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Academic Article
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The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
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Academic Article
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Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-? and AIM2 inflammasome-dependent IL-1? production via its ESX-1 secretion system.
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Academic Article
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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
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Academic Article
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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
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Academic Article
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Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
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Academic Article
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Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity.
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Academic Article
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Rift Valley fever virus infection induces activation of the NLRP3 inflammasome.
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Academic Article
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Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
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Academic Article
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Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.
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Academic Article
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Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.
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Academic Article
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TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
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Academic Article
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TRIL is involved in cytokine production in the brain following Escherichia coli infection.
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Academic Article
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Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1? production in response to ?-glucans and the fungal pathogen, Candida albicans.
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Academic Article
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IKK? negatively regulates ASC-dependent inflammasome activation.
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Academic Article
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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
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Academic Article
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Identification of Aim2 as a sensor for DNA vaccines.
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Academic Article
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Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
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Academic Article
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Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
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Academic Article
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GBPs take AIM at Francisella.
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Academic Article
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Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
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Academic Article
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Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.
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Academic Article
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An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
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Academic Article
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Gadolinium-based compounds induce NLRP3-dependent IL-1? production and peritoneal inflammation.
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Academic Article
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Cutting Edge: DNA in the Lung Microenvironment during Influenza Virus Infection Tempers Inflammation by Engaging the DNA Sensor AIM2.
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Academic Article
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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
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Academic Article
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Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
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Academic Article
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Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.
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Academic Article
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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.
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Academic Article
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Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.
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Academic Article
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Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.
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Academic Article
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
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Academic Article
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The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.
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Academic Article
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IRF3 and type I interferons fuel a fatal response to myocardial infarction.
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Academic Article
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Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
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Academic Article
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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.
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Academic Article
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Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
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Academic Article
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Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
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Academic Article
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CNBP controls IL-12 gene transcription and Th1 immunity.
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Academic Article
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
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Academic Article
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Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
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Academic Article
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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
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