| Item Type | Name |
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Academic Article
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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
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Academic Article
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Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction.
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Academic Article
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
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Academic Article
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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
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Academic Article
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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
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Academic Article
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The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.
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Academic Article
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TOLLing away in Brazil.
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Academic Article
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Immunology. The shape of things to come.
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Academic Article
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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
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Academic Article
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Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
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Academic Article
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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
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Academic Article
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
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Academic Article
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Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
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Academic Article
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IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway.
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Academic Article
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Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling.
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Academic Article
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Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).
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Academic Article
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TLR4 is a negative regulator in noninfectious lung inflammation.
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Academic Article
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Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome.
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Academic Article
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Catenin' on to nucleic acid sensing.
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Academic Article
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Pattern recognition receptors and the innate immune response to viral infection.
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Academic Article
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Activation of autophagy by inflammatory signals limits IL-1? production by targeting ubiquitinated inflammasomes for destruction.
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Academic Article
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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
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Academic Article
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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.
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Academic Article
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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
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Academic Article
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Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1?.
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Academic Article
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Molecular basis of DNA recognition in the immune system.
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Academic Article
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The Toll-IL-1 receptor adaptor family grows to five members.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.
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Academic Article
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TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.
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Academic Article
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Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
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Academic Article
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Interferon gene regulation: not all roads lead to Tolls.
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Academic Article
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Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex.
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Academic Article
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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
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Academic Article
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Sorting out Toll signals.
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Academic Article
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Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
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Academic Article
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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Academic Article
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Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
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Academic Article
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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
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Academic Article
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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
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Academic Article
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Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
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Academic Article
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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.
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Academic Article
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Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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Academic Article
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Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signaling.
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Academic Article
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Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
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Academic Article
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Recognition of herpesviruses by the innate immune system.
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Academic Article
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Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
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Academic Article
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Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
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Academic Article
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Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice.
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Academic Article
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
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Academic Article
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Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16.
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Academic Article
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Regulation of inflammasome signaling.
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Academic Article
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Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor.
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Academic Article
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The NLRP12 inflammasome recognizes Yersinia pestis.
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Academic Article
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5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
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Academic Article
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Cutting edge: FAS (CD95) mediates noncanonical IL-1? and IL-18 maturation via caspase-8 in an RIP3-independent manner.
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Academic Article
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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
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Academic Article
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RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge.
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Academic Article
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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
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Concept
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Signal Transduction
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Academic Article
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Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
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Academic Article
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Cutting edge: TLR signaling licenses IRAK1 for rapid activation of the NLRP3 inflammasome.
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Academic Article
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STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease.
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Academic Article
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Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production.
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Academic Article
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.
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Academic Article
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Post-transcriptional regulation of gene expression in innate immunity.
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Academic Article
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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
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Academic Article
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TRIL is involved in cytokine production in the brain following Escherichia coli infection.
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Academic Article
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Citrobacter rodentium: infection, inflammation and the microbiota.
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Academic Article
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Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice.
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Academic Article
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A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.
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Academic Article
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Mechanisms of inflammasome activation: recent advances and novel insights.
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Academic Article
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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease.
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Academic Article
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An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual.
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Academic Article
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Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice.
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Academic Article
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A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines.
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Academic Article
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Inflammasome Complexes: Emerging Mechanisms and Effector Functions.
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Academic Article
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Control of the innate immune response by the mevalonate pathway.
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Academic Article
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Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity.
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Academic Article
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
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Academic Article
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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
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Academic Article
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Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.
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Academic Article
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Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.
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Academic Article
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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
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Academic Article
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cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
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Academic Article
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Activation of Stimulator of Interferon Genes (STING) and Sj?gren Syndrome.
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Academic Article
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DNA sensing by the cGAS-STING pathway in health and disease.
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Academic Article
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Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
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Academic Article
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Toll-like Receptors and the Control of Immunity.
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Academic Article
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Long non-coding RNAs in antiviral immunity.
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Academic Article
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1? expression.
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Academic Article
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TLR2 Dimerization Blockade Allows Generation of Homeostatic Intestinal Macrophages under Acute Colitis Challenge.
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Academic Article
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cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE.
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Academic Article
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Cellular nucleic acid-binding protein is essential for type I interferon-mediated immunity to RNA virus infection.
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Academic Article
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Epithelial HNF4A shapes the intraepithelial lymphocyte compartment via direct regulation of immune signaling molecules.
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Academic Article
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Regulation of Synovial ?d T Cell Ligand Expression by Mitochondrial Reactive Oxygen Species and Gasdermin-D.
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Academic Article
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STING-dependent interferon signatures restrict osteoclast differentiation and bone loss in mice.
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Academic Article
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ERADication of STING limits inflammation.
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Academic Article
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Targeting STING oligomerization with small-molecule inhibitors.
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Academic Article
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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer.
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Academic Article
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DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.
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