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Biography

Kate Fitzgerald received her B.Sc. in 1995 from University College Cork, Ireland, and her Ph.D. in 1999 from Trinity College Dublin, Ireland. From 1999 to 2001, she was a post-doctoral fellow in the Department of Biochemistry at Trinity College Dublin in the Laboratory of Professor Luke O'Neill. Dr. Fitzgerald joined the Division of Infectious Disease at the University of Massachusetts Medical School as a recipient of a Welcome Trust International Award in 2001. In 2004 she joined the Faculty as an Assistant Professor and is currently Professor of Medicine and Director of the Program in Innate Immunity (www.umassmed.edu/pii).

Research Information  Katherine Photo

INNATE IMMUNE SIGNALING

Research in the Fitzgerald lab is focused on understanding the molecular basis of host defense and the inflammatory process. Active research areas include: (1) mechanisms and biology of caspase-1 activating inflammasome complexes, (2) nucleic acid sensors, with a particular focus on cytosolic DNA recognition systems and (3) role of long non-coding RNAs (lincRNAs) in the regulation of inflammatory gene expression. Enabling these studies, our research uses immunology, molecular biology, biochemistry and genetics to understand these mechanisms. Our longer term goals are to understand how dysregulation of sensing, signaling and gene regulation in innate immunity underlie the pathogenesis of infectious, inflammatory and autoimmune disease in humans.

One or more keywords matched the following items that are connected to Fitzgerald, Katherine
Item TypeName
Academic Article IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Academic Article TOLLing away in Brazil.
Academic Article Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance.
Academic Article Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination.
Academic Article A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts.
Academic Article A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Academic Article Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.
Academic Article TLR4 is a negative regulator in noninfectious lung inflammation.
Academic Article The interferon inducible gene: Viperin.
Academic Article Molecular basis of DNA recognition in the immune system.
Academic Article The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury.
Academic Article A long noncoding RNA mediates both activation and repression of immune response genes.
Academic Article TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression.
Academic Article The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence.
Academic Article Interferon gene regulation: not all roads lead to Tolls.
Academic Article Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1.
Academic Article The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis.
Academic Article Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression.
Academic Article Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signaling.
Academic Article Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein.
Academic Article Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus.
Academic Article Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-? and RANTES production.
Academic Article Regulation of lipopolysaccharide-induced translation of tumor necrosis factor-alpha by the toll-like receptor 4 adaptor protein TRAM.
Academic Article Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein.
Academic Article Regulation of inflammasome signaling.
Academic Article 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Concept Down-Regulation
Concept Up-Regulation
Concept Gene Expression Regulation
Concept Gene Expression Regulation, Viral
Concept Gene Expression Regulation, Neoplastic
Academic Article The transcriptional repressor BLIMP1 curbs host defenses by suppressing expression of the chemokine CCL8.
Academic Article Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation.
Academic Article Post-transcriptional regulation of gene expression in innate immunity.
Academic Article TRIM13 is a negative regulator of MDA5-mediated type I interferon production.
Academic Article IKK? negatively regulates ASC-dependent inflammasome activation.
Academic Article Transcription of inflammatory genes: long noncoding RNA and beyond.
Academic Article Long non-coding RNAs and control of gene expression in the immune system.
Academic Article Suppression of systemic autoimmunity by the innate immune adaptor STING.
Academic Article Cutting Edge: A Natural Antisense Transcript, AS-IL1?, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1?.
Academic Article Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.
Academic Article IMMUNOLOGY. An RNA twist to T(H)17 cells.
Academic Article A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.
Academic Article Immunobiology of Long Noncoding RNAs.
Academic Article Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.
Academic Article The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.
Academic Article Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.
Academic Article Cytokines and Long Noncoding RNAs.
Academic Article HiChIRP reveals RNA-associated chromosome conformation.
Academic Article Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection.
Academic Article Long non-coding RNAs in antiviral immunity.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Academic Article AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma.
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