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Search Results to Raymond M Welsh PhD

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Academic Background

PhD, 1972, University of Massachusetts, Amherst

Dr. Ray Welsh

Viral Immunology and pathogenesis

The focus of our research is on analyzing basic mechanisms of viral immunology and immunopathology. To do this, we study mouse model infections with a variety of viruses, including lymphocytic choriomeningitis virus, murine cytomegalovirus (MCMV), vaccinia virus, Pichinde virus, mouse hepatitis virus, herpes simplex virus, polyomavirus, Sindbis virus, and others. Our laboratory has demonstrated that natural killer cells become activated during viral infections and contribute to natural resistance to viruses, though they sometimes can act antagonistically by interfering with anti-viral T cell responses. We identified a receptor on NK cells that enables them to control MCMV infection. We also examine the dynamics of CD8 T cell activation, death by apoptosis, and memory in viral infections. A major area of research defined by our lab is on heterologous immunity, whereby the T and B cell immune response elicited by one virus may alter the pathogenesis of disease initiated by a second unrelated virus. This is sometimes mediated by T cells cross-reactive between unrelated viruses. We have also shown that virus-specific T cells often cross-react with allogeneic tissue, and we are studying the role of those cross-reactive T cells in allograft rejection.

One or more keywords matched the following items that are connected to Welsh, Raymond

Item TypeName
Academic Article Assessing CD8 T cell number and dysfunction in the presence of antigen.
Academic Article T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens.
Academic Article Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation.
Academic Article Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Academic Article Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.
Academic Article Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments.
Academic Article Plasticity of T cell memory responses to viruses.
Academic Article Immunological memory to viral infections.
Academic Article CD8 T cell responses to viral infections in sequence.
Academic Article CD8 memory T cells: cross-reactivity and heterologous immunity.
Academic Article IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections.
Academic Article Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
Academic Article Consequences of cross-reactive and bystander CTL responses during viral infections.
Academic Article Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation.
Academic Article High frequencies of virus-specific CD8+ T-cell precursors.
Academic Article Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists.
Academic Article Heterologous immunity between viruses.
Academic Article No one is naive: the significance of heterologous T-cell immunity.
Academic Article B cell memory: sapping the T cell.
Academic Article Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections.
Academic Article Apoptosis and loss of virus-specific CD8+ T-cell memory.
Academic Article Origin and fate of lymphocytic choriomeningitis virus-specific CD8+ T cells coexpressing the inhibitory NK cell receptor Ly49G2.
Academic Article Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope.
Academic Article Private specificities of CD8 T cell responses control patterns of heterologous immunity.
Academic Article Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis.
Academic Article Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
Academic Article Private specificities of heterologous immunity.
Academic Article Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.
Academic Article The privacy of T cell memory to viruses.
Academic Article Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses.
Academic Article Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus.
Academic Article Attrition of memory CD8 T cells.
Academic Article CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
Academic Article Computer simulations of heterologous immunity: highlights of an interdisciplinary cooperation.
Concept Immunologic Memory
Academic Article Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection.
Academic Article Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
Academic Article Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells.
Academic Article Evaluation of non-reciprocal heterologous immunity between unrelated viruses.
Academic Article Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Academic Article Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.

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  • Memory