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Search Results to Raymond M Welsh PhD

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Academic Background

PhD, 1972, University of Massachusetts, Amherst

Dr. Ray Welsh

Viral Immunology and pathogenesis

The focus of our research is on analyzing basic mechanisms of viral immunology and immunopathology. To do this, we study mouse model infections with a variety of viruses, including lymphocytic choriomeningitis virus, murine cytomegalovirus (MCMV), vaccinia virus, Pichinde virus, mouse hepatitis virus, herpes simplex virus, polyomavirus, Sindbis virus, and others. Our laboratory has demonstrated that natural killer cells become activated during viral infections and contribute to natural resistance to viruses, though they sometimes can act antagonistically by interfering with anti-viral T cell responses. We identified a receptor on NK cells that enables them to control MCMV infection. We also examine the dynamics of CD8 T cell activation, death by apoptosis, and memory in viral infections. A major area of research defined by our lab is on heterologous immunity, whereby the T and B cell immune response elicited by one virus may alter the pathogenesis of disease initiated by a second unrelated virus. This is sometimes mediated by T cells cross-reactive between unrelated viruses. We have also shown that virus-specific T cells often cross-react with allogeneic tissue, and we are studying the role of those cross-reactive T cells in allograft rejection.


One or more keywords matched the following items that are connected to Welsh, Raymond

Item TypeName
Academic Article Assessing CD8 T cell number and dysfunction in the presence of antigen.
Academic Article T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens.
Academic Article Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation.
Academic Article Dynamics of Ly49 expressing cytotoxic lymphocyte subsets in response to virus infection.
Academic Article Direct visualization of cross-reactive effector and memory allo-specific CD8 T cells generated in response to viral infections.
Academic Article Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.
Academic Article Attrition of virus-specific memory CD8+ T cells during reconstitution of lymphopenic environments.
Academic Article Plasticity of T cell memory responses to viruses.
Academic Article CD8 T cell responses to viral infections in sequence.
Academic Article CD8 memory T cells: cross-reactivity and heterologous immunity.
Academic Article Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction.
Academic Article An elderly woman with a non-healing ulcer. Marjolin's ulcer.
Academic Article IFN-induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections.
Academic Article Role for TLR2 in NK cell-mediated control of murine cytomegalovirus in vivo.
Academic Article Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity.
Academic Article Dynamics and magnitude of virus-induced polyclonal B cell activation mediated by BCR-independent presentation of viral antigen.
Academic Article Immunogenicity of influenza virus vaccine is increased by anti-gal-mediated targeting to antigen-presenting cells.
Academic Article Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation.
Academic Article Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage.
Academic Article High frequencies of virus-specific CD8+ T-cell precursors.
Academic Article Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists.
Academic Article Tumor viral escape from inhibited T cells.
Academic Article NK cells and gammadelta T cells mediate resistance to polyomavirus-induced tumors.
Academic Article Virus-induced transient immune suppression and the inhibition of T cell proliferation by type I interferon.
Academic Article Viral abrogation of stem cell transplantation tolerance causes graft rejection and host death by different mechanisms.
Academic Article No one is naive: the significance of heterologous T-cell immunity.
Academic Article B cell memory: sapping the T cell.
Academic Article Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Academic Article Possible role of a cell surface carbohydrate in evolution of resistance to viral infections in old world primates.
Academic Article Inflammatory cytokine-mediated evasion of virus-induced tumors from NK cell control.
Academic Article Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung.
Academic Article Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections.
Academic Article Biochemical and functional analysis of smallpox growth factor (SPGF) and anti-SPGF monoclonal antibodies.
Academic Article Apoptosis and loss of virus-specific CD8+ T-cell memory.
Academic Article Origin and fate of lymphocytic choriomeningitis virus-specific CD8+ T cells coexpressing the inhibitory NK cell receptor Ly49G2.
Academic Article Preapoptotic phenotype of viral epitope-specific CD8 T cells precludes memory development and is an intrinsic property of the epitope.
Academic Article Cutting edge: MHC class II-restricted killing in vivo during viral infection.
Academic Article Private specificities of CD8 T cell responses control patterns of heterologous immunity.
Academic Article Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo.
Academic Article Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells.
Academic Article Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis.
Academic Article TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
Academic Article Private specificities of heterologous immunity.
Academic Article Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity.
Academic Article Rapid quantification of naive alloreactive T cells by TNF-alpha production and correlation with allograft rejection in mice.
Academic Article The privacy of T cell memory to viruses.
Academic Article Immune system derived from homeostatic proliferation generates normal CD8 T-cell memory but altered repertoires and diminished heterologous immune responses.
Academic Article Multiple glycines in TCR alpha-chains determine clonally diverse nature of human T cell memory to influenza A virus.
Academic Article CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses.
Academic Article TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article Attrition of memory CD8 T cells.
Academic Article Generation of protective T cell-independent antiviral antibody responses in SCID mice reconstituted with follicular or marginal zone B cells.
Academic Article Blimp hovers over T cell immunity.
Academic Article CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
Academic Article Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis.
Academic Article IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Academic Article Bi-specific MHC heterodimers for characterization of cross-reactive T cells.
Academic Article Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes.
Academic Article Maturation-dependent licensing of naive T cells for rapid TNF production.
Academic Article Natural killer cells act as rheostats modulating antiviral T cells.
Academic Article Mice completely lacking immunoproteasomes show major changes in antigen presentation.
Academic Article Type 1 interferons and antiviral CD8 T-cell responses.
Academic Article Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope.
Academic Article Alloreactive CD8 T cells rescued from apoptosis during co-stimulation blockade by Toll-like receptor stimulation remain susceptible to Fas-induced cell death.
Academic Article NK cells controlling virus-specific T cells: Rheostats for acute vs. persistent infections.
Concept NK Cell Lectin-Like Receptor Subfamily K
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Receptors, NK Cell Lectin-Like
Concept Cell Lineage
Concept Receptors, Antigen, T-Cell
Concept NK Cell Lectin-Like Receptor Subfamily D
Concept Hematopoietic Stem Cell Transplantation
Concept Hela Cells
Concept Cell Division
Concept Cell Survival
Concept Receptors, Cell Surface
Concept Dendritic Cells
Concept Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor
Concept Tumor Cells, Cultured
Concept Cell Differentiation
Concept Cell Line, Transformed
Concept Antibody-Producing Cells
Concept Cell Movement
Concept Lymphoma, B-Cell, Marginal Zone
Concept Cells, Cultured
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Cell Proliferation
Concept Vero Cells
Concept Receptors, Natural Killer Cell
Concept Cell Cycle
Concept Clone Cells
Concept K562 Cells
Concept Carcinoma, Squamous Cell
Concept Genes, T-Cell Receptor alpha
Concept Antigen-Presenting Cells
Concept Precursor Cells, T-Lymphoid
Concept Cell Line
Concept NK Cell Lectin-Like Receptor Subfamily C
Concept Receptors, Antigen, B-Cell
Concept NK Cell Lectin-Like Receptor Subfamily B
Concept Killer Cells, Natural
Concept Cell Line, Tumor
Concept Cell Count
Academic Article Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection.
Academic Article Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
Academic Article Long-lasting T cell-independent IgG responses require MyD88-mediated pathways and are maintained by high levels of virus persistence.
Academic Article Therapeutic depletion of natural killer cells controls persistent infection.
Academic Article Clonal exhaustion as a mechanism to protect against severe immunopathology and death from an overwhelming CD8 T cell response.
Academic Article Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.
Academic Article NK cells and virus-related cancers.
Academic Article Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.
Academic Article MHC basis of T cell-dependent heterologous immunity to arenaviruses.
Academic Article Out-of-sequence signal 3 as a mechanism for virus-induced immune suppression of CD8 T cell responses.
Academic Article Regulatory T cells resist virus infection-induced apoptosis.
Academic Article Generation of cellular immune memory and B-cell immunity is impaired by natural killer cells.
Academic Article The Mitochondrial Phosphatase PGAM5 Is Dispensable for Necroptosis but Promotes Inflammasome Activation in Macrophages.
Academic Article IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.
Academic Article Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity.
Academic Article Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires.
Academic Article Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Academic Article Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity.
Academic Article Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells.
Academic Article Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
Academic Article Virus-induced natural killer cell lysis of T cell subsets.

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