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One or more keywords matched the following properties of Welsh, Raymond
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Academic Background

PhD, 1972, University of Massachusetts, Amherst

Dr. Ray Welsh

Viral Immunology and pathogenesis

The focus of our research is on analyzing basic mechanisms of viral immunology and immunopathology. To do this, we study mouse model infections with a variety of viruses, including lymphocytic choriomeningitis virus, murine cytomegalovirus (MCMV), vaccinia virus, Pichinde virus, mouse hepatitis virus, herpes simplex virus, polyomavirus, Sindbis virus, and others. Our laboratory has demonstrated that natural killer cells become activated during viral infections and contribute to natural resistance to viruses, though they sometimes can act antagonistically by interfering with anti-viral T cell responses. We identified a receptor on NK cells that enables them to control MCMV infection. We also examine the dynamics of CD8 T cell activation, death by apoptosis, and memory in viral infections. A major area of research defined by our lab is on heterologous immunity, whereby the T and B cell immune response elicited by one virus may alter the pathogenesis of disease initiated by a second unrelated virus. This is sometimes mediated by T cells cross-reactive between unrelated viruses. We have also shown that virus-specific T cells often cross-react with allogeneic tissue, and we are studying the role of those cross-reactive T cells in allograft rejection.

One or more keywords matched the following items that are connected to Welsh, Raymond
Item TypeName
Academic Article Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction.
Academic Article High frequencies of virus-specific CD8+ T-cell precursors.
Academic Article Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire.
Academic Article Specific history of heterologous virus infections determines anti-viral immunity and immunopathology in the lung.
Academic Article Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections.
Academic Article Private specificities of CD8 T cell responses control patterns of heterologous immunity.
Academic Article CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses.
Academic Article CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
Academic Article Bi-specific MHC heterodimers for characterization of cross-reactive T cells.
Academic Article Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Concept Vaccinia virus
Concept Vaccinia
Academic Article Disparate epitopes mediating protective heterologous immunity to unrelated viruses share peptide-MHC structural features recognized by cross-reactive T cells.
Academic Article Evaluation of non-reciprocal heterologous immunity between unrelated viruses.
Academic Article Weak vaccinia virus-induced NK cell regulation of CD4 T cells is associated with reduced NK cell differentiation and cytolytic activity.
Search Criteria
  • Vaccinia