Header Logo

Search Result Details

Back to Search Results
This page shows the details of why an item matched the keywords from your search.
Search Results
Serreze, David
One or more keywords matched the following properties of Serreze, David
PropertyValue
Person ID 2838
phone 207-288-6403
One or more keywords matched the following items that are connected to Serreze, David
Item TypeName
Academic Article During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.
Academic Article NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene.
Academic Article By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma.
Academic Article Tracking autoimmune T cells in diabetes.
Academic Article Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.
Academic Article Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.
Academic Article Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.
Academic Article Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Academic Article Was there type 1 diabetes in the Olduvai Gorge?
Academic Article Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles.
Academic Article Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans.
Academic Article Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Academic Article HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.
Academic Article Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Academic Article CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Academic Article Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Academic Article Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.
Academic Article TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Academic Article Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.
Academic Article Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.
Academic Article Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.
Academic Article Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.
Academic Article Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans.
Academic Article Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.
Academic Article Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a ?-cell neo-self-antigen in type 1 diabetes prone NOD mice.
Academic Article Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
Academic Article Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.
Academic Article International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
Academic Article Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice.
Academic Article Autoimmunity's next top models.
Academic Article A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes.
Academic Article Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.
Academic Article Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.
Academic Article The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes.
Academic Article The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.
Academic Article Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.
Academic Article Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.
Academic Article B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice.
Academic Article Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4.
Academic Article CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice.
Academic Article Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.
Academic Article Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.
Academic Article The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.
Academic Article Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.
Academic Article Invasion of the killer B's in type 1 diabetes.
Academic Article Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype.
Academic Article Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Academic Article "Humanized" HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes.
Academic Article In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.
Academic Article Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.
Academic Article Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.
Academic Article Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.
Academic Article A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Academic Article Peripherin-reactive antibodies in mouse, rabbit, and human blood.
Academic Article Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses.
Academic Article Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Academic Article Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Academic Article B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.
Concept Cytokines
Concept Insulin
Concept Immunotherapy
Concept Enzyme-Linked Immunosorbent Assay
Concept T-Lymphocytes, Cytotoxic
Concept Disease Models, Animal
Concept Molecular Weight
Concept Interleukin-10
Concept Hominidae
Concept Subcellular Fractions
Concept Motor Activity
Concept Muramidase
Concept Receptors, Interleukin-17
Concept Interferon-gamma
Concept Immunologic Surveillance
Concept Humans
Concept Animals, Congenic
Concept Feces
Concept Flow Cytometry
Concept Hematopoietic Stem Cell Transplantation
Concept CD8 Antigens
Concept Incidence
Concept Complementarity Determining Regions
Concept CD4 Antigens
Concept Vaccines, DNA
Concept Recurrence
Concept PTEN Phosphohydrolase
Concept Nervous System Autoimmune Disease, Experimental
Concept Metalloporphyrins
Concept CD40 Antigens
Concept COS Cells
Concept CD5 Antigens
Concept Paleontology
Concept Forkhead Transcription Factors
Concept Peritoneum
Concept 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Concept Mice, Inbred BALB C
Concept Myocarditis
Concept Neuritis, Autoimmune, Experimental
Concept Disease Progression
Concept CD8-Positive T-Lymphocytes
Concept Lymphocyte Count
Concept RNA Editing
Concept Hypoglycemic Agents
Concept B-Lymphocyte Subsets
Concept Antigens, Differentiation, T-Lymphocyte
Concept Self Tolerance
Concept Genes, T-Cell Receptor beta
Concept Intermediate Filament Proteins
Concept Electrophoresis, Gel, Two-Dimensional
Concept Cell Adhesion
Concept HLA-B Antigens
Concept Receptors, Interferon
Concept Receptors, Interleukin-2
Concept 4-1BB Ligand
Concept T-Lymphocytes, Helper-Inducer
Concept Bone Marrow Transplantation
Concept Cricetinae
Concept Administration, Oral
Concept Antigens, CD1
Concept Lysosomes
Concept Dogs
Concept Retroelements
Concept Chromones
Concept Vitamin D
Concept Tumor Necrosis Factor Receptor Superfamily, Member 7
Concept B-Cell Activation Factor Receptor
Concept Disease Susceptibility
Concept Homeostasis
Concept Dendritic Cells
Concept Ligands
Concept Trans-Activators
Concept Amino Acid Sequence
Concept ADP-ribosyl Cyclase 1
Concept Immunophenotyping
Concept Mice, Knockout
Concept Antibodies
Concept Grooming
Concept Mice, Inbred C3H
Concept Epitope Mapping
Concept Hypocalcemia
Concept Iris
Concept Calcium
Concept Cytidine Deaminase
Concept Genes, Immunoglobulin
Concept Colorectal Neoplasms
Concept TRPV Cation Channels
Concept Blotting, Western
Concept Histocompatibility Antigens Class I
Concept T-Lymphocytes, Regulatory
Concept Immunity, Mucosal
Concept B7-1 Antigen
Concept Transplantation Tolerance
Concept Diabetes Mellitus
Concept Genetic Predisposition to Disease
Concept Genetic Loci
Concept Anxiety
Concept T-Lymphocyte Subsets
Concept Cholera Vaccines
Concept Glycine Plasma Membrane Transport Proteins
Concept Epitopes, T-Lymphocyte
Concept Immunoglobulins
Concept Concanavalin A
Concept Chromosomes, Human, Pair 7
Concept CD11c Antigen
Concept Clonal Anergy
Concept Glaucoma, Open-Angle
Concept Cell Line, Transformed
Concept Aqueous Humor
Concept Insulin Resistance
Concept Transcription, Genetic
Concept Tumor Necrosis Factor-alpha
Concept Immunity, Innate
Concept Immunologic Techniques
Concept HLA-DQ Antigens
Concept B7-2 Antigen
Concept CD4-CD8 Ratio
Concept Eye
Concept Transgenes
Concept CD40 Ligand
Concept Plasma Cells
Concept Adjuvants, Immunologic
Concept Mutagenesis, Insertional
Concept Mice, Inbred C57BL
Concept Lectins, C-Type
Concept Maze Learning
Concept Galactosylceramides
Concept Chromosomes, Mammalian
Concept HLA-A2 Antigen
Concept Insulin-Secreting Cells
Concept Cells, Cultured
Concept Interleukins
Concept T-Lymphocytes
Concept Transplantation Chimera
Concept Antigens, CD
Concept Myositis
Concept Chickens
Concept Neuroblastoma
Concept Skin Transplantation
Concept Natural Killer T-Cells
Concept Interleukin-2
Concept Neuromuscular Junction
Concept RNA, Messenger
Concept Cell Proliferation
Concept Homeodomain Proteins
Concept Antigen Presentation
Concept Clonal Deletion
Concept CD27 Ligand
Concept Lymphocytes
Concept Major Histocompatibility Complex
Concept Adoptive Transfer
Concept Substance P
Concept Microscopy, Fluorescence
Concept STAT4 Transcription Factor
Concept Psychomotor Performance
Concept Autoantibodies
Concept Cholera Toxin
Concept Mice, Inbred NOD
Concept Blood Glucose
Concept Cytotoxicity, Immunologic
Concept Antibodies, Monoclonal
Concept Cell Membrane
Concept Coculture Techniques
Concept Crystallography, X-Ray
Concept Environmental Monitoring
Concept Glucose-6-Phosphatase
Concept Vaccines, Synthetic
Concept Sharks
Concept Cell Culture Techniques
Concept Sjogren's Syndrome
Concept Lymphocyte Activation
Concept Glucocorticoid-Induced TNFR-Related Protein
Concept Lymphocyte Depletion
Concept Peroxynitrous Acid
Concept Clone Cells
Concept Genetic Carrier Screening
Concept Tumor Necrosis Factor Receptor Superfamily, Member 9
Concept Immunoglobulin Heavy Chains
Concept Glutamate Decarboxylase
Concept Protein Tyrosine Phosphatases
Concept Animal Husbandry
Concept B-Cell Activating Factor
Concept Gram-Positive Bacterial Infections
Concept Th1 Cells
Concept Candidiasis, Chronic Mucocutaneous
Concept Interleukin-4
Concept Lymph Nodes
Concept Quantitative Trait Loci
Concept Genes, T-Cell Receptor alpha
Concept Adenoviridae
Concept Mice, Congenic
Concept NAD
Concept Histocompatibility Antigens Class II
Concept Insulinoma
Concept CD4-Positive T-Lymphocytes
Concept HLA-A Antigens
Concept Corticosterone
Concept beta 2-Microglobulin
Concept Diabetes Mellitus, Type 1
Concept I-kappa B Proteins
Concept Immunoglobulin Class Switching
Concept Autoimmunity
Concept Adenovirus E3 Proteins
Concept Diet
Concept Prediabetic State
Concept 5'-Nucleotidase
Concept ADP Ribose Transferases
Concept HLA Antigens
Concept H-2 Antigens
Concept Histocompatibility Testing
Concept Neural Inhibition
Concept Cell Line
Concept STAT1 Transcription Factor
Concept B-Lymphocytes
Concept Deoxyribonucleases
Concept Chimera
Concept Antigens, CD20
Concept Hemocyanins
Concept Immunoglobulin Fc Fragments
Concept Immunoglobulin mu-Chains
Concept Chromatography, Affinity
Concept Enterovirus B, Human
Concept Capsaicin
Concept Eosinophils
Concept Mice, Inbred DBA
Concept Asthma
Concept Islets of Langerhans Transplantation
Concept Islets of Langerhans
Concept Promoter Regions, Genetic
Concept Diabetes Mellitus, Experimental
Concept Alleles
Concept Killer Cells, Natural
Concept Interferon Type I
Concept Biological Evolution
Concept Dog Diseases
Concept Injections, Intravenous
Concept Cell Line, Tumor
Concept Molecular Sequence Data
Concept Janus Kinases
Concept Radiation Chimera
Concept Protein Engineering
Concept Lymphocyte Subsets
Concept Immunologic Memory
Concept Lymphocyte Transfusion
Concept Cell Count
Concept Genes, MHC Class I
Academic Article Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.
Academic Article DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8? T cells independently of PD-1 and PD-L1.
Academic Article In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.
Academic Article Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.
Academic Article Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice.
Academic Article The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo.
Academic Article Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.
Academic Article Sudden acquired retinal degeneration syndrome (SARDS) - a review and proposed strategies toward a better understanding of pathogenesis, early diagnosis, and therapy.
Academic Article B-lymphocytes expressing an Ig specificity recognizing the pancreatic ?-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice.
Academic Article Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.
Academic Article Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
Academic Article Interferon-? Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.
Academic Article Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Academic Article Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice.
Academic Article Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.
Academic Article HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.
Academic Article A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.
Academic Article Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development.
Academic Article CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.
Academic Article Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus.
Academic Article B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes.
Academic Article Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction.
Academic Article Interleukin-27 Is Essential for Type 1 Diabetes Development and Sj?gren Syndrome-like Inflammation.
Academic Article The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells.
Academic Article Decreased pancreatic acinar cell number in type 1 diabetes.
Academic Article CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
Academic Article T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue.
Academic Article CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Academic Article Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice.
Academic Article Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
Academic Article Interleukin-27 is essential for type 1 diabetes development and Sj?gren syndrome-like inflammation.
Academic Article Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
Concept Abatacept
Concept Gastrointestinal Microbiome
Concept Rituximab
Concept Forkhead Box Protein O3
Concept Mice, 129 Strain
Concept Receptors, Purinergic P2X7
Concept Th17 Cells
Concept Antibodies, Monoclonal, Murine-Derived
Concept Disease Resistance
Concept B7-H1 Antigen
Concept V-Set Domain-Containing T-Cell Activation Inhibitor 1
Concept Programmed Cell Death 1 Receptor
Concept Peripheral Tolerance
Concept B-Lymphocytes, Regulatory
Concept Thymocytes
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept CRISPR-Cas Systems
Concept Microbiota
Concept Histocompatibility Antigen H-2D
Academic Article Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells.
Academic Article Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies.
Academic Article Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes.
Academic Article Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes.
Academic Article HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice.
Academic Article Deletion of V?3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.
Academic Article Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.
Academic Article Advancing Animal Models of Human Type 1 Diabetes.
Academic Article Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans.
Academic Article Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response.
Search Criteria
  • 4
  • 4
  • Diisothiocyanostilbene
  • 2
  • 2
  • Disulfonic
  • Acid