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Serreze, David

One or more keywords matched the following items that are connected to Serreze, David

Item Type	Name
Academic Article	During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.
Academic Article	NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article	Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene.
Academic Article	By altering ocular immune privilege, bone marrow-derived cells pathogenically contribute to DBA/2J pigmentary glaucoma.
Academic Article	Tracking autoimmune T cells in diabetes.
Academic Article	Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article	Genetic analysis of resistance to Type-1 Diabetes in ALR/Lt mice, a NOD-related strain with defenses against autoimmune-mediated diabetogenic stress.
Academic Article	Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article	Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article	Enhanced pathogenicity of diabetogenic T cells escaping a non-MHC gene-controlled near death experience.
Academic Article	Individual nonobese diabetic mice exhibit unique patterns of CD8+ T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase.
Academic Article	Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon.
Academic Article	Was there type 1 diabetes in the Olduvai Gorge?
Academic Article	Rapid destruction of encapsulated islet xenografts by NOD mice is CD4-dependent and facilitated by B-cells: innate immunity and autoimmunity do not play significant roles.
Academic Article	Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans.
Academic Article	Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis.
Academic Article	HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes.
Academic Article	Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.
Academic Article	CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice.
Academic Article	Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression.
Academic Article	Genes within the Idd5 and Idd9/11 diabetes susceptibility loci affect the pathogenic activity of B cells in nonobese diabetic mice.
Academic Article	TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.
Academic Article	Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice.
Academic Article	Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells.
Academic Article	Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice.
Academic Article	Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article	Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette.
Academic Article	Bridging mice to men: using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans.
Academic Article	Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.
Academic Article	Enhanced responsiveness to T-cell help causes loss of B-lymphocyte tolerance to a ?-cell neo-self-antigen in type 1 diabetes prone NOD mice.
Academic Article	Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach.
Academic Article	Targeting of a T cell agonist peptide to lysosomes by DNA vaccination induces tolerance in the nonobese diabetic mouse.
Academic Article	International Workshop on Lessons from Animal Models for Human Type 1 Diabetes: analyzing target autoantigens of humoral immunity in nonobese diabetic mice.
Academic Article	Calcium insufficiency accelerates type 1 diabetes in vitamin D receptor-deficient nonobese diabetic (NOD) mice.
Academic Article	Autoimmunity's next top models.
Academic Article	A MusD retrotransposon insertion in the mouse Slc6a5 gene causes alterations in neuromuscular junction maturation and behavioral phenotypes.
Academic Article	Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice.
Academic Article	Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.
Academic Article	The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes.
Academic Article	The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.
Academic Article	Adenovirus early region 3 antiapoptotic 10.4K, 14.5K, and 14.7K genes decrease the incidence of autoimmune diabetes in NOD mice.
Academic Article	Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.
Academic Article	Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article	MHC class II molecules play a role in the selection of autoreactive class I-restricted CD8 T cells that are essential contributors to type 1 diabetes development in nonobese diabetic mice.
Academic Article	B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice.
Academic Article	Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4.
Academic Article	CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice.
Academic Article	Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11.6K.
Academic Article	Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article	Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes.
Academic Article	The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice.
Academic Article	Major histocompatibility complex-linked diabetes susceptibility in NOD/Lt mice: subcongenic analysis localizes a component of Idd16 at the H2-D end of the diabetogenic H2(g7) complex.
Academic Article	Invasion of the killer B's in type 1 diabetes.
Academic Article	Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype.
Academic Article	Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
Academic Article	"Humanized" HLA transgenic NOD mice to identify pancreatic beta cell autoantigens of potential clinical relevance to type 1 diabetes.
Academic Article	In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice.
Academic Article	Through regulation of TCR expression levels, an Idd7 region gene(s) interactively contributes to the impaired thymic deletion of autoreactive diabetogenic CD8+ T cells in nonobese diabetic mice.
Academic Article	Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice.
Academic Article	A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes.
Academic Article	Peripherin-reactive antibodies in mouse, rabbit, and human blood.
Academic Article	Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses.
Academic Article	Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Academic Article	Loss of intra-islet CD20 expression may complicate efficacy of B-cell-directed type 1 diabetes therapies.
Academic Article	B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.
Concept	Mice, Inbred BALB C
Concept	Mice, Knockout
Concept	Mice, Inbred C3H
Concept	Mice
Concept	Mice, Inbred C57BL
Concept	Mice, Transgenic
Concept	Mammary Tumor Virus, Mouse
Concept	Mice, Inbred NOD
Concept	Mice, Nude
Concept	Mice, SCID
Concept	Mice, Congenic
Concept	Mice, Inbred DBA
Academic Article	Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice.
Academic Article	DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8? T cells independently of PD-1 and PD-L1.
Academic Article	In vivo detection of peripherin-specific autoreactive B cells during type 1 diabetes pathogenesis.
Academic Article	Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responses.
Academic Article	Genetic Analysis of Substrain Divergence in Non-Obese Diabetic (NOD) Mice.
Academic Article	The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article	Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo.
Academic Article	Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans.
Academic Article	B-lymphocytes expressing an Ig specificity recognizing the pancreatic ?-cell autoantigen peripherin are potent contributors to type 1 diabetes development in NOD mice.
Academic Article	Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice.
Academic Article	Autoimmune manifestations in aged mice arise from early-life immune dysregulation.
Academic Article	Interferon-? Limits Diabetogenic CD8+ T-Cell Effector Responses in Type 1 Diabetes.
Academic Article	Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes.
Academic Article	Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice.
Academic Article	Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy.
Academic Article	HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.
Academic Article	A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8+ T Cells in NOD Mice.
Academic Article	Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development.
Academic Article	CD11c+ Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes.
Academic Article	Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus.
Academic Article	B-Lymphocyte Phenotype Determines T-Lymphocyte Subset Differentiation in Autoimmune Diabetes.
Academic Article	Therapeutic administration of Tregitope-Human Albumin Fusion with Insulin Peptides to promote Antigen-Specific Adaptive Tolerance Induction.
Academic Article	Interleukin-27 Is Essential for Type 1 Diabetes Development and Sj?gren Syndrome-like Inflammation.
Academic Article	The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137+ FOXP3+ Regulatory CD4 T Cells.
Academic Article	Decreased pancreatic acinar cell number in type 1 diabetes.
Academic Article	CD70 Inversely Regulates Regulatory T Cells and Invariant NKT Cells and Modulates Type 1 Diabetes in NOD Mice.
Academic Article	T Cells from NOD-PerIg Mice Target Both Pancreatic and Neuronal Tissue.
Academic Article	CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Academic Article	Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice.
Academic Article	Aberrant type 1 immunity drives susceptibility to mucosal fungal infections.
Academic Article	Response to Comments on "Aberrant type 1 immunity drives susceptibility to mucosal fungal infections".
Concept	Mice, 129 Strain
Academic Article	Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells.
Academic Article	Microbiota-dependent proteolysis of gluten subverts diet-mediated protection against type 1 diabetes.
Academic Article	Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes.
Academic Article	HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice.
Academic Article	Deletion of V?3+CD4+ T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8+ T cells.
Academic Article	Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.
Academic Article	Advancing Animal Models of Human Type 1 Diabetes.
Academic Article	Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans.

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