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Shultz, Leonard

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Person ID	2863
phone	207-288-6405

One or more keywords matched the following items that are connected to Shultz, Leonard

Item Type	Name
Academic Article	Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice.
Academic Article	Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation.
Academic Article	Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.
Academic Article	Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article	Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article	CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
Academic Article	Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.
Academic Article	Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.
Academic Article	Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.
Academic Article	LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors.
Academic Article	An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
Academic Article	Characteristics of long-term human thyroid peroxidase autoantibody secretion in scid mice transplanted with lymphocytes from patients with autoimmune thyroiditis.
Academic Article	Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant.
Academic Article	Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice.
Academic Article	Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase.
Academic Article	Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras.
Academic Article	Diethylcarbamazine (DEC) does not induce nitric oxide (NO) synthesis.
Academic Article	Lymphadenopathy, elevated serum IgE levels, autoimmunity, and mast cell accumulation in flaky skin mutant mice.
Academic Article	Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Academic Article	Tumorigenicity of green turtle fibropapilloma-derived fibroblast lines in immunodeficient mice.
Academic Article	Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice.
Academic Article	NZB mice exhibit a primary T cell defect in fetal thymic organ culture.
Academic Article	Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
Academic Article	Evaluation of monoclonal antibody-mediated anti-acute myeloid leukemia immunotherapy in a SCID/hu model.
Academic Article	B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.
Academic Article	Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article	The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Academic Article	Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization.
Academic Article	Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
Academic Article	Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Academic Article	B cells are selectively associated with thymic cortical but not medullary pathology in NZB mice.
Academic Article	Increased expression of mXBP-1 (TREB-5) in thymic B cells in New Zealand mice.
Academic Article	Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article	Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article	Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice.
Academic Article	The molecular bases of spontaneous immunological mutations in the mouse and their homologous human diseases.
Academic Article	A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.
Academic Article	Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article	Blockade of CD40-CD154 interferes with human T cell engraftment in scid mice.
Academic Article	Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease.
Academic Article	Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article	Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice.
Academic Article	Mutations in the gene encoding the lamin B receptor produce an altered nuclear morphology in granulocytes (Pelger-Hu?t anomaly).
Academic Article	Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses.
Academic Article	Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor.
Academic Article	Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors.
Academic Article	Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Academic Article	The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus.
Academic Article	SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity.
Academic Article	Suppressive effects of monocytic cells and transforming growth factor-beta on natural killer cell differentiation in autoimmune viable motheaten mutant mice.
Academic Article	Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Hu?t anomaly.
Academic Article	Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.
Academic Article	Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5.
Academic Article	IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection.
Academic Article	Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article	T cell receptor expression is not required for the localization and differentiation of intraepithelial lymphocytes.
Academic Article	Bombesin/gastrin-releasing peptide receptor: a potential target for antibody-mediated therapy of small cell lung cancer.
Academic Article	Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article	Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.
Academic Article	Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten mice.
Academic Article	A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigens.
Academic Article	Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article	Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density.
Academic Article	The soluble interleukin-6 (IL-6) receptor/IL-6 fusion protein enhances in vitro maintenance and proliferation of human CD34(+)CD38(-/low) cells capable of repopulating severe combined immunodeficiency mice.
Academic Article	Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article	Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Academic Article	Induction of the alpha(1)-antichymotrypsin gene in the brain associated with TGF-beta1 deficiency or systemic administration of endotoxin.
Academic Article	Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article	An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice.
Academic Article	Phorbol ester responsiveness of murine Ly-1-lineage B cells from normal and viable motheaten mutant mice.
Academic Article	The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.
Academic Article	Human cord blood--derived cells generate insulin-producing cells in vivo.
Academic Article	NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article	B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.
Academic Article	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
Academic Article	Humanized mice: are we there yet?
Academic Article	Expression of terminal differentiation proteins defines stages of mouse mammary gland development.
Academic Article	Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion.
Academic Article	Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Academic Article	Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article	Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.
Academic Article	beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article	Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice.
Academic Article	Lanceolate hair-J (lahJ): a mouse model for human hair disorders.
Academic Article	Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras.
Academic Article	Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor.
Academic Article	Defective macrophage recruitment and clearance of apoptotic cells in the uterus of osteopetrotic mutant mice lacking macrophage colony-stimulating factor (M-CSF).
Academic Article	Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions.
Academic Article	Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Academic Article	Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice.
Academic Article	Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Academic Article	Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Academic Article	Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Academic Article	The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene.
Academic Article	Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
Academic Article	Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article	The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.
Academic Article	Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance.
Academic Article	Effect of aging on epidermal dendritic cell populations in C57BL/6J mice.
Academic Article	Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion.
Academic Article	The differentiative and regenerative properties of human hematopoietic stem/progenitor cells in NOD-SCID/IL2rgamma(null) mice.
Academic Article	Creation of "humanized" mice to study human immunity.
Academic Article	Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses.
Academic Article	In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.
Academic Article	Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article	The mouse mutant "motheaten". I. Development of lymphocyte populations.
Academic Article	Conditioned media from mouse osteosarcoma cells promote MC3T3-E1 cell proliferation using JAKs and PI3-K/Akt signal crosstalk.
Academic Article	The mouse mutant "motheaten." II. Functional studies of the immune system.
Academic Article	Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article	Cancer stem cells are enriched in the side population cells in a mouse model of glioma.
Academic Article	Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.
Academic Article	Fas deficiency delays the resolution of airway hyperresponsiveness after allergen sensitization and challenge.
Academic Article	Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice.
Academic Article	Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Academic Article	Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article	Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article	In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase.
Academic Article	Dysferlin deficiency and the development of cardiomyopathy in a mouse model of limb-girdle muscular dystrophy 2B.
Academic Article	Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite.
Academic Article	Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article	Humanized mouse models to study human diseases.
Academic Article	Vaginal transmission of cell-associated HIV-1 in the mouse is blocked by a topical, membrane-modifying agent.
Academic Article	Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.
Academic Article	Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Academic Article	T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Academic Article	Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Academic Article	Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants.
Academic Article	Opportunistic bacterial infections in breeding colonies of the NSG mouse strain.
Academic Article	Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process.
Academic Article	Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen.
Academic Article	Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article	Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Academic Article	Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis.
Academic Article	Epidermal growth factor receptors in spontaneous ovarian granulosa cell tumors of SWR-derived mice.
Academic Article	Humanized mouse models of HIV-1 latency.
Academic Article	Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article	Pneumocystis carinii pneumonia in scid/scid mice.
Academic Article	Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Academic Article	Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody.
Academic Article	Human allograft rejection in humanized mice: a historical perspective.
Academic Article	Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article	Characterization of Mott cell hybridomas from autoimmune "viable motheaten" mutant mice.
Academic Article	Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
Academic Article	Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.
Academic Article	Humanized mouse model used to monitor MUC gene expression in nasal polyps and to preclinically evaluate the efficacy of montelukast in reducing mucus production.
Academic Article	In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue.
Academic Article	Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma.
Academic Article	Humanized mice for immune system investigation: progress, promise and challenges.
Academic Article	Inflammatory dilated cardiomyopathy in Abcg5-deficient mice.
Academic Article	Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation.
Academic Article	Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in Hairpatches (Hpt) mice.
Academic Article	GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article	Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice.
Academic Article	A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo.
Academic Article	Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone.
Academic Article	The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function.
Academic Article	Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Academic Article	Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.
Academic Article	T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.
Academic Article	Mouse models of genetic diseases.
Academic Article	Pleiotropic effects of deleterious alleles at the "motheaten" locus.
Academic Article	Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. II. Description of a microenvironmental defect for the generation of terminal deoxynucleotidyltransferase-positive bone marrow cells in vitro.
Academic Article	Pleiotropic mutations causing abnormalities in the murine immune system and the skin.
Academic Article	Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article	Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article	Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article	NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article	Hairpatches, a single gene mutation characterized by progressive renal disease and alopecia in the mouse. A potential model for a newly described heritable human disorder.
Academic Article	Fate of listeria monocytogenes in normal rabbit serum.
Academic Article	Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha.
Academic Article	Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro.
Academic Article	Immunodeficiency and reticulum cell sarcoma in mice segregating for HRS/J and SJL/J genes.
Academic Article	Novel B-cell maturation factor from spontaneously autoimmune viable motheaten mice.
Academic Article	'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia.
Academic Article	The contribution of mast cells to the histamine content of the central nervous system: a regional analysis.
Academic Article	Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.
Academic Article	Graves' disease thyroid tissue transplants in scid mice: persistent selectivity in hTcR Va gene family use.
Academic Article	Cellular origin of follicular dendritic cells.
Academic Article	Maternal influence on susceptibility of offspring to Brugia malayi infection in a murine model of filariasis.
Academic Article	Abnormal nuclear morphology of leukocytes in the mouse mutant ichthyosis.
Academic Article	Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture.
Academic Article	Engraftment of human lymphocytes and thyroid tissue into scid and rag2-deficient mice: absent progression of lymphocytic infiltration.
Academic Article	Granulosa cell tumorigenesis in genetically hypogonadal-immunodeficient mice grafted with ovaries from tumor-susceptible donors.
Academic Article	The inner nuclear membrane protein lamin B receptor forms distinct microdomains and links epigenetically marked chromatin to the nuclear envelope.
Academic Article	Epidermal dendritic cell populations in the flaky skin mutant mouse.
Academic Article	Differentiation of dendritic cell populations in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation.
Academic Article	Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article	Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article	Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells.
Academic Article	SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner.
Academic Article	Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article	Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article	Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Academic Article	Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.
Academic Article	Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature.
Academic Article	TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article	The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
Academic Article	Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Academic Article	The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion.
Academic Article	Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa.
Academic Article	Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Academic Article	In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models.
Academic Article	Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.
Academic Article	Humanized mice in translational biomedical research.
Academic Article	Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article	Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J mice.
Academic Article	Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2.
Academic Article	Determinants of memory in experimental filarial infections in mice.
Academic Article	Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region.
Academic Article	A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article	CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL.
Academic Article	Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Academic Article	Humanized SCID mouse models for biomedical research.
Academic Article	A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article	Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article	Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Academic Article	T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article	Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article	Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger.
Academic Article	Humanized mice for the study of type 1 diabetes and beta cell function.
Academic Article	Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia.
Academic Article	The mouse mutant "wasted": an animal model for ataxia-telangiectasia.
Academic Article	Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.
Academic Article	TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article	Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article	Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Academic Article	Identification of Pneumocystis carinii in immunodeficient mice.
Academic Article	The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.
Academic Article	Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article	Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production.
Academic Article	Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice.
Academic Article	NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article	Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.
Academic Article	Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells.
Academic Article	Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article	Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article	High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice.
Academic Article	HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/?c(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.
Academic Article	A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
Academic Article	Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article	Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.
Academic Article	Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Academic Article	Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).
Academic Article	Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article	Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article	Ex?vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice.
Academic Article	Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article	Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice.
Academic Article	The mouse mutation severe combined immune deficiency (scid) is on chromosome 16.
Academic Article	Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo.
Academic Article	Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article	Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-?-catenin signaling.
Academic Article	Loss of function of the mouse Sharpin gene results in Peyer's patch regression.
Academic Article	Suppression of SHP-1 promotes corticospinal tract sprouting and functional recovery after brain injury.
Academic Article	Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article	Humanized mice for the study of infectious diseases.
Academic Article	A new in vivo screening paradigm to accelerate antimalarial drug discovery.
Academic Article	Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation.
Academic Article	Non-germ-line elements (NGE) are present in the T cell receptor beta-chain genes isolated from the mutant mouse, motheaten (me/me).
Academic Article	NOD marrow stem cells adoptively transfer diabetes to resistant (NOD x NON)F1 mice.
Academic Article	The immunological mouse mutants nude (nu) and rhino (hrrh) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Production of immunoglobulin isotypes by Ly-1+ B cells in viable motheaten and normal mice.
Academic Article	Gamma-interferon is one of several direct B cell-maturing lymphokines.
Academic Article	Thymic epithelial cell abnormalities in (NZB x H-2u)F1 mice.
Academic Article	Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes.
Academic Article	Programmed differentiation of murine thymocytes during fetal thymus organ culture.
Academic Article	Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus.
Academic Article	Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.
Academic Article	Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice.
Academic Article	Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity.
Academic Article	Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.
Concept	Cell Fusion
Concept	Antigens, Ly
Concept	X-Linked Inhibitor of Apoptosis Protein
Concept	Cytokines
Concept	Angiogenesis Inhibitors
Concept	Filaricides
Concept	Vascular Endothelial Growth Factor A
Concept	src Homology Domains
Concept	Insulin
Concept	Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
Concept	Basic Helix-Loop-Helix Transcription Factors
Concept	Extracellular Matrix
Concept	Age Factors
Concept	Neutrophils
Concept	Karyotyping
Concept	T-Lymphocytes, Cytotoxic
Concept	Disease Models, Animal
Concept	Precision Medicine
Concept	Dexamethasone
Concept	N-Glycosyl Hydrolases
Concept	SOXB1 Transcription Factors
Concept	Graves Disease
Concept	Femur
Concept	Peritoneal Cavity
Concept	Protein Phosphatase 1
Concept	Granulocyte Colony-Stimulating Factor
Concept	CD56 Antigen
Concept	Brain Neoplasms
Concept	Extracellular Space
Concept	Transforming Growth Factor beta
Concept	Nucleoside Deaminases
Concept	Survival Rate
Concept	Genes, Regulator
Concept	Basophils
Concept	NF-kappa B
Concept	Blood Pressure
Concept	Interferon-gamma
Concept	Endothelium, Lymphatic
Concept	Cell Lineage
Concept	Cytotoxicity Tests, Immunologic
Concept	Anemia, Macrocytic
Concept	Nitrates
Concept	Bleomycin
Concept	Animals, Newborn
Concept	Muscle Proteins
Concept	Cyclin A1
Concept	Cerebellum
Concept	Erythroid Precursor Cells
Concept	Mitochondria
Concept	Flow Cytometry
Concept	Hematopoietic Stem Cell Transplantation
Concept	CD8 Antigens
Concept	Tumor Suppressor Protein p53
Concept	Prostatic Neoplasms
Concept	Chromosomes, Human, Pair 17
Concept	Filtration
Concept	Phosphoprotein Phosphatases
Concept	CD4 Antigens
Concept	HeLa Cells
Concept	Erythropoietin
Concept	Recurrence
Concept	Morbidity
Concept	Calcium-Calmodulin-Dependent Protein Kinases
Concept	Doxorubicin
Concept	DNA-Activated Protein Kinase
Concept	Cell Nucleus
Concept	S Phase
Concept	Cell Division
Concept	Interleukin-13
Concept	Collagenases
Concept	Antigens, Differentiation
Concept	Drug Design
Concept	Purkinje Cells
Concept	Ascitic Fluid
Concept	Actins
Concept	Gene Expression
Concept	Fetal Blood
Concept	CD40 Antigens
Concept	Genes, MHC Class II
Concept	Matrix Metalloproteinase 1
Concept	COS Cells
Concept	Macrophage Activation
Concept	Membrane Potentials
Concept	CD5 Antigens
Concept	Desmosomes
Concept	Forkhead Transcription Factors
Concept	Dietary Fats
Concept	RNA Interference
Concept	Peritoneum
Concept	Fluorescent Dyes
Concept	NAD+ Nucleosidase
Concept	DNA, Complementary
Concept	Fluorescent Antibody Technique
Concept	Interleukin-15
Concept	Body Weight
Concept	Blood
Concept	Disease Progression
Concept	CD8-Positive T-Lymphocytes
Concept	Desmogleins
Concept	Lymphocyte Count
Concept	Antigen-Antibody Complex
Concept	Beta-Globulins
Concept	Cadherins
Concept	Ceramides
Concept	Immunoglobulin D
Concept	Lymphocytic Choriomeningitis
Concept	B-Lymphocyte Subsets
Concept	Dipeptidyl Peptidase 4
Concept	Receptors, Bombesin
Concept	Antigens, Differentiation, T-Lymphocyte
Concept	Lupus Vulgaris
Concept	RANK Ligand
Concept	Endothelium, Vascular
Concept	Axons
Concept	Receptors, Granulocyte Colony-Stimulating Factor
Concept	Hematopoietic Cell Growth Factors
Concept	Cell Adhesion Molecules
Concept	Chromosomes
Concept	Electroporation
Concept	Polyomavirus
Concept	Glucagon-Secreting Cells
Concept	Injections
Concept	Cell Adhesion
Concept	Large Neutral Amino Acid-Transporter 1
Concept	Dependovirus
Concept	Mitogen-Activated Protein Kinase Kinases
Concept	Respiratory Burst
Concept	T-Lymphocytes, Helper-Inducer
Concept	Gene Rearrangement, B-Lymphocyte, Heavy Chain
Concept	Ataxia Telangiectasia
Concept	Rats, Inbred Lew
Concept	Genomics
Concept	Carboxylesterase
Concept	Antibodies, Neutralizing
Concept	Protein Tyrosine Phosphatase, Non-Receptor Type 6
Concept	Blood Cell Count
Concept	Interferons
Concept	Endoplasmic Reticulum
Concept	Jurkat Cells
Concept	Progesterone
Concept	Antibodies, Antinuclear
Concept	Erythrocytes
Concept	Immunochemistry
Concept	Syndrome
Concept	Antigens, CD7
Concept	Histamine
Concept	Disease Susceptibility
Concept	Carrier Proteins
Concept	Myeloid Differentiation Factor 88
Concept	Dendritic Cells
Concept	Genes
Concept	TNF Receptor-Associated Factor 1
Concept	Chronic Disease
Concept	Genes, RAG-1
Concept	STAT5 Transcription Factor
Concept	Trans-Activators
Concept	Amino Acid Sequence
Concept	Insulin-Like Growth Factor I
Concept	Klebsiella oxytoca
Concept	Genomic Islands
Concept	Chromosomes, Human
Concept	ADP-ribosyl Cyclase 1
Concept	Mice, Hairless
Concept	Immunophenotyping
Concept	Clodronic Acid
Concept	Baculoviridae
Concept	Nuclear Envelope
Concept	Bone Density Conservation Agents
Concept	Diacylglycerol Kinase
Concept	Cisplatin
Concept	Antineoplastic Agents
Concept	Lac Operon
Concept	Mesenchymal Stem Cell Transplantation
Concept	Myocytes, Cardiac
Concept	Methacholine Chloride
Concept	Desmoplakins
Concept	Lipid Peroxidation
Concept	Genes, fos
Concept	Culture Media
Concept	Calcium
Concept	Lewis X Antigen
Concept	Desmoglein 1
Concept	Genes, Immunoglobulin
Concept	Intracellular Membranes
Concept	Acute Disease
Concept	STAT3 Transcription Factor
Concept	Antibodies, Viral
Concept	Blotting, Western
Concept	Exosomes
Concept	Salmonella
Concept	Brugia malayi
Concept	Pancreatic Neoplasms
Concept	T-Lymphocytes, Regulatory
Concept	Hemolytic Plaque Technique
Concept	Crohn Disease
Concept	Interleukin-11
Concept	B7-1 Antigen
Concept	E-Selectin
Concept	Cardiomyopathies
Concept	Injections, Subcutaneous
Concept	Chemokine CXCL2
Concept	Fucose
Concept	Translocation, Genetic
Concept	Diabetes Mellitus
Concept	Hydrocortisone
Concept	Genetic Predisposition to Disease
Concept	Spectral Karyotyping
Concept	Pneumococcal Vaccines
Concept	T-Lymphocyte Subsets
Concept	Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Concept	Hyaluronan Receptors
Concept	Macrophage-Activating Factors
Concept	Tumor Cells, Cultured
Concept	Protein Tyrosine Phosphatase, Non-Receptor Type 11
Concept	Chemotaxis, Leukocyte
Concept	Clinical Protocols
Concept	Iron
Concept	Typhoid Fever
Concept	Leukotriene B4
Concept	Lymphokines
Concept	Lymphocytes, Tumor-Infiltrating
Concept	Activating Transcription Factor 3
Concept	Caspase 3
Concept	Leukocyte Count
Concept	Energy Metabolism
Concept	Thy-1 Antigens
Concept	Bacillus subtilis
Concept	Chromatin
Concept	Interleukin-5
Concept	Receptors, IgE
Concept	Densitometry
Concept	Lymphoid Progenitor Cells
Concept	Epidermis
Concept	Founder Effect
Concept	Salmonella typhi
Concept	Cell Line, Transformed
Concept	Tritium
Concept	DNA Primers
Concept	Leukocyte Common Antigens
Concept	Histocytochemistry
Concept	Drug Evaluation, Preclinical
Concept	tat Gene Products, Human Immunodeficiency Virus
Concept	Pulmonary Eosinophilia
Concept	Adenocarcinoma
Concept	Transcription, Genetic
Concept	Echocardiography
Concept	Organelles
Concept	HIV Envelope Protein gp120
Concept	Leukocytes
Concept	Tumor Necrosis Factor-alpha
Concept	Antibody-Dependent Cell Cytotoxicity
Concept	Cecum
Concept	Repressor Proteins
Concept	B7-2 Antigen
Concept	CD4-CD8 Ratio
Concept	Estrogens
Concept	Exons
Concept	Cerebral Cortex
Concept	Hot Temperature
Concept	Cattle
Concept	Meiosis
Concept	Transgenes
Concept	Diabetes Mellitus, Type 2
Concept	T-Box Domain Proteins
Concept	Proto-Oncogene Proteins c-kit
Concept	Dengue Virus
Concept	CD40 Ligand
Concept	Complement System Proteins
Concept	Receptors, Leukotriene B4
Concept	Ovariectomy
Concept	Plasma Cells
Concept	CD3 Complex
Concept	Interleukin-7
Concept	Muromonab-CD3
Concept	GATA1 Transcription Factor
Concept	Dengue
Concept	Galactosylceramides
Concept	Toll-Like Receptor 2
Concept	Polyomavirus Infections
Concept	Computational Biology
Concept	HLA-A2 Antigen
Concept	Gastric Bypass
Concept	Insulin-Secreting Cells
Concept	Organ Size
Concept	Colony-Forming Units Assay
Concept	Cells, Cultured
Concept	Colitis, Ulcerative
Concept	Venoms
Concept	Liver Neoplasms
Concept	Blood Platelets
Concept	Cell Separation
Concept	T-Lymphocytes
Concept	Transplantation Chimera
Concept	Calcineurin
Concept	Myofibrils
Concept	Coxsackievirus Infections
Concept	Herpesvirus 4, Human
Concept	Administration, Topical
Concept	Phosphoric Monoester Hydrolases
Concept	Tetradecanoylphorbol Acetate
Concept	Granulocyte-Macrophage Colony-Stimulating Factor
Concept	Lymphocyte Culture Test, Mixed
Concept	Antigens, CD
Concept	Transforming Growth Factor beta1
Concept	Bowman Capsule
Concept	Injections, Intraperitoneal
Concept	Skin Transplantation
Concept	Omentum
Concept	Phytosterols
Concept	Monocytes
Concept	Dermatitis, Contact
Concept	Viral Load
Concept	fms-Like Tyrosine Kinase 3
Concept	Interleukin-2
Concept	N-Acetylneuraminic Acid
Concept	Yttrium Radioisotopes
Concept	Endostatins
Concept	Tuberculosis
Concept	Xenograft Model Antitumor Assays
Concept	Carotid Artery Injuries
Concept	CD24 Antigen
Concept	ADP-ribosyl Cyclase
Concept	Diethylcarbamazine
Concept	Cell Proliferation
Concept	Homeodomain Proteins
Concept	beta Catenin
Concept	Vaccines
Concept	Suppressor of Cytokine Signaling Proteins
Concept	Granulocytes
Concept	Keratins
Concept	Thioglycolates
Concept	Plasma
Concept	Muromegalovirus
Concept	Codon, Terminator
Concept	Chromosomes, Human, Pair 15
Concept	Cardiomegaly
Concept	Glucose Clamp Technique
Concept	Interleukin-1
Concept	Dystrophin
Concept	Lymphocytes
Concept	Langerhans Cells
Concept	Sodium Hydroxide
Concept	Radiation Dosage
Concept	Major Histocompatibility Complex
Concept	Receptors, Lymphocyte Homing
Concept	Estradiol
Concept	Epithelium
Concept	Subrenal Capsule Assay
Concept	Proto-Oncogene Proteins c-myc
Concept	Inclusion Bodies
Concept	Erythema Nodosum
Concept	Genes, Reporter
Concept	Carcinoma, Non-Small-Cell Lung
Concept	Etoposide
Concept	Brain Injuries
Concept	Interferon Regulatory Factor-1
Concept	Severe Combined Immunodeficiency
Concept	Zinc
Concept	DNA, Satellite
Concept	Body Burden
Concept	Neutralization Tests
Concept	Microsatellite Repeats
Concept	Cytotoxicity, Immunologic
Concept	Antibodies, Monoclonal
Concept	Pituitary Gland, Anterior
Concept	Cord Blood Stem Cell Transplantation
Concept	Liposomes
Concept	Granzymes
Concept	Osteoprotegerin
Concept	Cytoplasmic Granules
Concept	Crystallography, X-Ray
Concept	Liver Transplantation
Concept	Alkaline Phosphatase
Concept	CA-125 Antigen
Concept	Cluster Analysis
Concept	Myeloid-Lymphoid Leukemia Protein
Concept	ATP-Binding Cassette Transporters
Concept	Green Fluorescent Proteins
Concept	Lipopolysaccharide Receptors
Concept	Eye Burns
Concept	ras Proteins
Concept	Corneal Diseases
Concept	Gene Knock-In Techniques
Concept	Glucose-6-Phosphatase
Concept	Metrizamide
Concept	Bleeding Time
Concept	Leukemia, Promyelocytic, Acute
Concept	SH2 Domain-Containing Protein Tyrosine Phosphatases
Concept	Gold
Concept	Cell Culture Techniques
Concept	Lymphocyte Activation
Concept	Nerve Growth Factors
Concept	Chromosomes, Human, Pair 1
Concept	Erythrocyte Count
Concept	Glucocorticoid-Induced TNFR-Related Protein
Concept	Antioxidants
Concept	Antimalarials
Concept	Capsid Proteins
Concept	Oxidation-Reduction
Concept	Stem Cell Factor
Concept	Mitogen-Activated Protein Kinase 7
Concept	Mycobacterium bovis
Concept	Electroretinography
Concept	Clone Cells
Concept	Serine Proteases
Concept	Glutamate Decarboxylase
Concept	Peripheral Blood Stem Cell Transplantation
Concept	Leukocytes, Mononuclear
Concept	Burns, Chemical
Concept	Desmoglein 3
Concept	Protein Tyrosine Phosphatases
Concept	Salmonella Infections
Concept	K562 Cells
Concept	Amyloid Precursor Protein Secretases
Concept	Th1 Cells
Concept	Antigens, CD34
Concept	Cyclophosphamide
Concept	Rats, Inbred F344
Concept	Erythrocyte Membrane
Concept	Interleukin-8
Concept	Interleukin-4
Concept	STAT6 Transcription Factor
Concept	Cycloheximide
Concept	4-Nitroquinoline-1-oxide
Concept	Receptor, Macrophage Colony-Stimulating Factor
Concept	Bromodeoxyuridine
Concept	Case-Control Studies
Concept	Chemokines, CXC
Concept	NF-E2-Related Factor 2
Concept	Chemokine CCL2
Concept	Epidermal Growth Factor
Concept	CCAAT-Enhancer-Binding Proteins
Concept	Leukemia, Myeloid, Acute
Concept	Microfilament Proteins
Concept	Trace Elements
Concept	Herpesviridae Infections
Concept	Gamma Rays
Concept	Granulosa Cells
Concept	CD4-Positive T-Lymphocytes
Concept	Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Concept	Antimetabolites, Antineoplastic
Concept	Dose-Response Relationship, Radiation
Concept	Stem Cell Transplantation
Concept	beta 2-Microglobulin
Concept	Sequence Homology, Amino Acid
Concept	Collagen
Concept	Diabetes Mellitus, Type 1
Concept	Immunoglobulin Class Switching
Concept	Autoradiography
Concept	Interleukin-6
Concept	Staining and Labeling
Concept	Image Processing, Computer-Assisted
Concept	Simian virus 40
Concept	In Situ Hybridization
Concept	Ear
Concept	Acetates
Concept	Apyrase
Concept	Dentin
Concept	Inflammatory Bowel Diseases
Concept	Carcinoma, Pancreatic Ductal
Concept	Genome-Wide Association Study
Concept	Immunization
Concept	Prediabetic State
Concept	Benzamides
Concept	Thymidine
Concept	DNA Replication
Concept	Interleukin-12
Concept	Macrophage Colony-Stimulating Factor
Concept	HIV Antibodies
Concept	Acid Phosphatase
Concept	Th2 Cells
Concept	Embryonic Stem Cells
Concept	Passive Cutaneous Anaphylaxis
Concept	Cell Growth Processes
Concept	Histocompatibility Testing
Concept	Blood Bactericidal Activity
Concept	Cytological Techniques
Concept	Cell Line
Concept	Motor Cortex
Concept	Adenosine Triphosphatases
Concept	Testosterone
Concept	Proto-Oncogene Proteins c-fos
Concept	Femoral Artery
Concept	STAT1 Transcription Factor
Concept	B-Lymphocytes
Concept	Chimera
Concept	Antigens, CD20
Concept	Integrin alpha4beta1
Concept	Brugia
Concept	Muscular Dystrophies, Limb-Girdle
Concept	Artemisinins
Concept	Heterochromatin
Concept	beta-Galactosidase
Concept	Sulfides
Concept	Epithelium, Corneal
Concept	Erythroblasts
Concept	Hippocampus
Concept	Paclitaxel
Concept	Granuloma
Concept	DNA Repair
Concept	Ovalbumin
Concept	Carboxylic Ester Hydrolases
Concept	Foreign-Body Reaction
Concept	Culture Media, Conditioned
Concept	Enterovirus B, Human
Concept	HLA-B27 Antigen
Concept	Osmotic Fragility
Concept	Antigens, CD19
Concept	Eosinophils
Concept	Adenosine Deaminase
Concept	Duodenum
Concept	Colony-Stimulating Factors
Concept	Dengue Vaccines
Concept	Cholesterol
Concept	Technetium
Concept	Antigens, Differentiation, B-Lymphocyte
Concept	In Situ Hybridization, Fluorescence
Concept	Cardiomyopathy, Dilated
Concept	Brugia pahangi
Concept	Islets of Langerhans Transplantation
Concept	Janus Kinase 2
Concept	MafB Transcription Factor
Concept	Chemokines
Concept	Epstein-Barr Virus Infections
Concept	Promoter Regions, Genetic
Concept	Diabetes Mellitus, Experimental
Concept	Environment
Concept	Dehydroepiandrosterone
Concept	Steroids
Concept	Dextrans
Concept	Listeriosis
Concept	Gene Silencing
Concept	Enterococcus
Concept	Fluorescent Antibody Technique, Indirect
Concept	Base Sequence
Concept	Alleles
Concept	Genes, Recessive
Concept	Zebrafish
Concept	Killer Cells, Natural
Concept	Interferon Type I
Concept	Salmonella typhimurium
Concept	Orchiectomy
Concept	Carcinoma, Small Cell
Concept	Sitosterols
Concept	Immunohistochemistry
Concept	Acetylglucosaminidase
Concept	Hybridomas
Concept	Colonic Neoplasms
Concept	Injections, Intravenous
Concept	Cell Line, Tumor
Concept	PAX7 Transcription Factor
Concept	Molecular Sequence Data
Concept	X Chromosome
Concept	Radiation Chimera
Concept	Milk Proteins
Concept	DNA Transposable Elements
Concept	Lymphocyte Subsets
Concept	Neuroimmunomodulation
Concept	Interleukin-3
Concept	Thrombopoietin
Concept	Chemokine CXCL12
Concept	Cell Count
Concept	Genes, MHC Class I
Concept	Tetanus Toxoid
Concept	Matrix Metalloproteinases
Academic Article	Regulated splicing of the a6 integrin cytoplasmic domain determines the fate of breast cancer stem cells.
Academic Article	Overcoming current limitations in humanized mouse research.
Academic Article	Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach.
Academic Article	Novel neuroprotective GSK-3? inhibitor restricts Tat-mediated HIV-1 replication.
Academic Article	Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice.
Academic Article	Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article	Improved function and proliferation of adult human beta cells engrafted in diabetic immunodeficient NOD-scid IL2r?(null) mice treated with alogliptin.
Academic Article	c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.
Academic Article	Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling.
Academic Article	An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.
Academic Article	NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article	Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Academic Article	Subcapsular transplantation of tissue in the kidney.
Academic Article	Human cancer growth and therapy in immunodeficient mouse models.
Academic Article	Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development.
Academic Article	Viral infection of engrafted human islets leads to diabetes.
Academic Article	A laminin 511 matrix is regulated by TAZ and functions as the ligand for the a6B?1 integrin to sustain breast cancer stem cells.
Academic Article	Generation of improved humanized mouse models for human infectious diseases.
Academic Article	Inhibition of bromodomain proteins for the treatment of human diffuse large B-cell lymphoma.
Academic Article	Dengue virus infection induces broadly cross-reactive human IgM antibodies that recognize intact virions in humanized BLT-NSG mice.
Academic Article	Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article	Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
Academic Article	MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.
Academic Article	Convergent mutations and kinase fusions lead to oncogenic STAT3 activation in anaplastic large cell lymphoma.
Academic Article	IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG.
Academic Article	Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.
Academic Article	The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article	Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article	Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors.
Academic Article	P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article	Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic ?-cell function via glycogen synthase kinase-3?.
Academic Article	Humanized Mouse Models for Transplant Immunology.
Academic Article	Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.
Academic Article	Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Academic Article	Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Academic Article	Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Academic Article	Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.
Academic Article	Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article	Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article	A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours.
Academic Article	Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article	Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
Academic Article	Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis.
Academic Article	Distinct Differences on Neointima Formation in Immunodeficient and Humanized Mice after Carotid or Femoral Arterial Injury.
Academic Article	A novel animal model for bone metastasis in human lung cancer.
Academic Article	Patient-Derived Tumor Xenografts: Why Now?
Academic Article	Humanized Mouse Models of Clinical Disease.
Academic Article	Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
Academic Article	Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Academic Article	Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2r?null Mice for Preclinical Ceramide-Based Therapeutic Evaluation.
Academic Article	Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
Academic Article	Development of Humanized Mice in the Age of Genome Editing.
Academic Article	A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
Academic Article	mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article	Genetic deletion of amphiregulin restores the normal skin phenotype in a mouse model of the human skin disease tylosis.
Academic Article	Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article	Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
Academic Article	Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.
Academic Article	a Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Academic Article	ADAM17 is essential for ectodomain shedding of the EGF-receptor ligand amphiregulin.
Academic Article	Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
Academic Article	Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article	Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article	RHBDF2-Regulated Growth Factor Signaling in a Rare Human Disease, Tylosis With Esophageal Cancer: What Can We Learn From Murine Models?
Academic Article	Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.
Academic Article	Genetic Models of Macrophage Depletion.
Academic Article	Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis.
Academic Article	Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery.
Academic Article	Mechanisms of genetically determined immune dysfunction.
Academic Article	A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.
Academic Article	Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article	Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics.
Academic Article	Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article	Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article	Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.
Academic Article	Humanized mouse models of immunological diseases and precision medicine.
Academic Article	Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Academic Article	Mesenchymal stem cells: From regeneration to cancer.
Academic Article	Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Academic Article	Humanized immune system mouse models: progress, challenges and opportunities.
Academic Article	Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop.
Academic Article	AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice.
Academic Article	Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article	Identification of a tumor-specific allo-HLA-restricted ?dTCR.
Academic Article	Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Academic Article	Human iPSC-derived microglia assume a primary microglia-like state after transplantation into the neonatal mouse brain.
Academic Article	Recovery of viable endocrine-specific cells and transcriptomes from human pancreatic islet-engrafted mice.
Academic Article	Tacrolimus- and sirolimus-induced human ? cell dysfunction is reversible and preventable.
Academic Article	TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice.
Academic Article	Improved mouse models and advanced genetic and genomic technologies for the study of neutrophils.
Academic Article	Dapagliflozin Does Not Directly Affect Human a or ? Cells.
Academic Article	Innovations, challenges, and minimal information for standardization of humanized mice.
Academic Article	Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.
Academic Article	Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
Academic Article	A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Academic Article	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.
Academic Article	Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis.
Academic Article	Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Academic Article	Targeting critical kinases and anti-apoptotic molecules overcomes steroid resistance in MLL-rearranged leukaemia.
Academic Article	Preclinical evaluation of cancer immune therapy using patient-derived tumor antigen-specific T cells in a novel xenograft platform.
Academic Article	A novel clinically relevant graft-versus-leukemia model in humanized mice.
Academic Article	Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models.
Academic Article	Role of MicroRNA in Inflammatory Bowel Disease: Clinical Evidence and the Development of Preclinical Animal Models.
Academic Article	Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Academic Article	Circulating CD34+?cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
Concept	Glucagon-Like Peptide-1 Receptor
Concept	Abatacept
Concept	Bevacizumab
Concept	Etanercept
Concept	Imatinib Mesylate
Concept	Rituximab
Concept	Bortezomib
Concept	Suppressor of Cytokine Signaling 1 Protein
Concept	Zinc Finger Protein GLI1
Concept	Regulatory Factor X Transcription Factors
Concept	X-Box Binding Protein 1
Concept	Epithelial Cell Adhesion Molecule
Concept	S100 Calcium-Binding Protein A4
Concept	Forkhead Box Protein M1
Concept	Gene Editing
Concept	S100 Calcium Binding Protein A6
Concept	2-Hydroxypropyl-beta-cyclodextrin
Concept	Dysferlin
Concept	T-Cell Acute Lymphocytic Leukemia Protein 1
Concept	THP-1 Cells
Concept	CD52 Antigen
Concept	Positive Regulatory Domain I-Binding Factor 1
Concept	Heat Shock Transcription Factors
Concept	HEK293 Cells
Concept	Single-Cell Analysis
Concept	Diet, High-Fat
Concept	Transcriptome
Concept	Receptors, Prostaglandin E, EP2 Subtype
Concept	Receptors, Prostaglandin E, EP4 Subtype
Concept	Antibodies, Monoclonal, Murine-Derived
Concept	Cell Engineering
Concept	CTLA-4 Antigen
Concept	Programmed Cell Death 1 Receptor
Concept	Antibodies, Monoclonal, Humanized
Concept	Primary Cell Culture
Concept	CCR5 Receptor Antagonists
Concept	HLA-A24 Antigen
Concept	Polycomb Repressive Complex 1
Concept	Carcinogenesis
Concept	Calbindins
Concept	S100 Calcium Binding Protein G
Concept	CRISPR-Cas Systems
Concept	S100 Calcium Binding Protein beta Subunit
Concept	EGF Family of Proteins
Concept	Amphiregulin
Academic Article	Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia.
Academic Article	Analysis of Salmonella Typhi Pathogenesis in a Humanized Mouse Model.
Academic Article	Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article	Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
Academic Article	Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells.
Academic Article	Humanized mouse models for immuno-oncology research.
Academic Article	Clathrin light chain-conjugated drug delivery for cancer.
Academic Article	Immunosuppressive reprogramming of neutrophils by lung mesenchymal cells promotes breast cancer metastasis.
Academic Article	NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Academic Article	Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection.
Academic Article	Generation of the NeoThy mouse model for human immune system studies.
Academic Article	Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Academic Article	Identification of a humanized mouse model for functional testing of immune-mediated biomaterial foreign body response.
Academic Article	Acute Myeloid Leukemia Causes T Cell Exhaustion and Depletion in a Humanized Graft-versus-Leukemia Model.
Academic Article	Bifunctional Inhibitor Reveals NEK2 as a Therapeutic Target and Regulator of Oncogenic Pathways in Lymphoma.
Academic Article	Genetic risk converges on regulatory networks mediating early type 2 diabetes.
Academic Article	Expression of endogenous murine leukaemia viruses in AKR/J streaker mice.
Academic Article	A human immune/muscle xenograft model of FSHD muscle pathology.
Academic Article	Human IL-6 fosters long-term engraftment of patient derived disease-driving myeloma cells in immunodeficient mice.
Academic Article	Nuclear factor kappa B-dependent persistence of Salmonella Typhi and Paratyphi in human macrophages.
Academic Article	Human IL-6 fosters long-term engraftment of patient-derived disease-driving myeloma cells in immunodeficient mice.
Academic Article	Human insulin as both antigen and protector in type 1 diabetes.
Academic Article	Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Academic Article	Development of New Diffuse Large B Cell Lymphoma Mouse Models.
Academic Article	Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Academic Article	Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles.

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