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Shultz, Leonard

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Item Type	Name
Academic Article	Mapping of the flaky skin (fsn) mutation on distal mouse chromosome 17.
Academic Article	The interleukin-12 beta subunit (p40) maps to mouse chromosome 11.
Academic Article	Effect of the mouse scid mutation on meiotic recombination.
Academic Article	Lack of peripherally induced tolerance to established skin allografts in immunologically reconstituted scid mice.
Academic Article	The murine thymic microenvironment: changes with age.
Academic Article	Follicular development and ovulation in macrophage colony-stimulating factor-deficient mice homozygous for the osteopetrosis (op) mutation.
Academic Article	Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice.
Academic Article	Neural and skin cell-specific expression pattern conferred by steel factor regulatory sequence in transgenic mice.
Academic Article	Phenotype and function of human hematopoietic cells engrafting immune-deficient CB17-severe combined immunodeficiency mice and nonobese diabetic-severe combined immunodeficiency mice after transplantation of human cord blood mononuclear cells.
Academic Article	Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation.
Academic Article	The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency.
Academic Article	Increased G-CSF responsiveness of bone marrow cells from hematopoietic cell phosphatase deficient viable motheaten mice.
Academic Article	Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.
Academic Article	Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.
Academic Article	Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent.
Academic Article	CD8+ T lymphocytes are not required for murine resistance to human filarial parasites.
Academic Article	Genetic mapping of the IL-12 alpha chain gene (Il12a) on mouse chromosome 3.
Academic Article	Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris.
Academic Article	Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice.
Academic Article	Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transduction.
Academic Article	Development of eosinophilic airway inflammation and airway hyperresponsiveness in mast cell-deficient mice.
Academic Article	Role of tumor necrosis factor-alpha in the spontaneous development of pulmonary fibrosis in viable motheaten mutant mice.
Academic Article	An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.
Academic Article	Development and progression of psoriasiform dermatitis and systemic lesions in the flaky skin (fsn) mouse mutant.
Academic Article	Effects of granulocyte/macrophage colony-stimulating factor on the development and differentiation of CD5-positive macrophages and their potential derivation from a CD5-positive B-cell lineage in mice.
Academic Article	Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphatase.
Academic Article	Mature human hematopoietic cells in donor bone marrow complicate interpretation of stem/progenitor cell assays in xenogeneic hematopoietic chimeras.
Academic Article	Follicular dendritic cell (FDC) precursors in primary lymphoid tissues.
Academic Article	A comparative analysis of the murine thymic microenvironment in normal, autoimmune, and immunodeficiency states.
Academic Article	Effects of macrophage colony-stimulating factor on macrophages and their related cell populations in the osteopetrosis mouse defective in production of functional macrophage colony-stimulating factor protein.
Academic Article	Role of nitric oxide in host defense against an extracellular, metazoan parasite, Brugia malayi.
Academic Article	CSF-1 regulation of Il6 gene expression by murine macrophages: a pivotal role for GM-CSF.
Academic Article	Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4.
Academic Article	Granulocyte/macrophage colony-stimulating factor and interleukin-3 correct osteopetrosis in mice with osteopetrosis mutation.
Academic Article	Thymic microenvironment and NZB mice: the abnormal thymic microenvironment of New Zealand mice correlates with immunopathology.
Academic Article	Tumorigenicity of green turtle fibropapilloma-derived fibroblast lines in immunodeficient mice.
Academic Article	NOD mice have a generalized defect in their response to transplantation tolerance induction.
Academic Article	Abnormal thymic expression of epithelial cell adhesion molecule (EP-CAM) in New Zealand Black (NZB) mice.
Academic Article	NZB mice exhibit a primary T cell defect in fetal thymic organ culture.
Academic Article	Growth of the human filarial parasite Brugia malayi in mice lacking major histocompatibility complex class II antigen expression.
Academic Article	B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.
Academic Article	Regulation of human cell engraftment and development of EBV-related lymphoproliferative disorders in Hu-PBL-scid mice.
Academic Article	The plant lectin FRIL supports prolonged in vitro maintenance of quiescent human cord blood CD34(+)CD38(-/low)/SCID repopulating stem cells.
Academic Article	Critical roles for interleukin-4 and interleukin-5 during respiratory syncytial virus infection in the development of airway hyperresponsiveness after airway sensitization.
Academic Article	Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice.
Academic Article	Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice.
Academic Article	B cells are selectively associated with thymic cortical but not medullary pathology in NZB mice.
Academic Article	Increased expression of mXBP-1 (TREB-5) in thymic B cells in New Zealand mice.
Academic Article	Macrophage differentiation and expression of macrophage colony-stimulating factor in murine milky spots and omentum after macrophage elimination.
Academic Article	Thymic involution in viable motheaten (me(v)) mice is associated with a loss of intrathymic precursor activity.
Academic Article	Variables to predict engraftment of umbilical cord blood into immunodeficient mice: usefulness of the non-obese diabetic--severe combined immunodeficient assay.
Academic Article	Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice.
Academic Article	A null mutation in inositol polyphosphate 4-phosphatase type I causes selective neuronal loss in weeble mutant mice.
Academic Article	Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.
Academic Article	Differentiation of epidermal Langerhans cells in macrophage colony-stimulating-factor-deficient mice homozygous for the osteopetrosis (op) mutation.
Academic Article	Aberrant regulation of bone trace elements in motheaten and osteopetrosis mutant mice.
Academic Article	Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4.
Academic Article	Age-related alterations in the lymphohematopoietic and B-lineage precursor populations in NZB mice.
Academic Article	Brugian infections in the peritoneal cavities of laboratory mice: kinetics of infection and cellular responses.
Academic Article	Bone remodeling and macrophage differentiation in osteopetrosis (op) mutant mice defective in the production of macrophage colony-stimulating factor.
Academic Article	Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice.
Academic Article	Prolonged survival of rat islet and skin xenografts in mice treated with donor splenocytes and anti-CD154 monoclonal antibody.
Academic Article	The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus.
Academic Article	Establishment and characterization of pro-B cell lines from motheaten mutant mouse defective in SHP-1 protein tyrosine phosphatase.
Academic Article	Isolation and characterization of a monoclonal anti-quadruplex DNA antibody from autoimmune "viable motheaten" mice.
Academic Article	Continuous infusion of endostatin inhibits differentiation, mobilization, and clonogenic potential of endothelial cell progenitors.
Academic Article	IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection.
Academic Article	Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice.
Academic Article	Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms?
Academic Article	Roles of a macrophage receptor with collagenous structure (MARCO) in host defense and heterogeneity of splenic marginal zone macrophages.
Academic Article	Appearance of human plasma cells following differentiation of human B cells in NOD/SCID mouse spleen.
Academic Article	Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten mice.
Academic Article	A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigens.
Academic Article	Immunity in experimental murine filariasis: roles of T and B cells revisited.
Academic Article	Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article	Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density.
Academic Article	Regulation of skin and islet allograft survival in mice treated with costimulation blockade is mediated by different CD4+ cell subsets and different mechanisms.
Academic Article	Evaluation of donor-specific transfusion sources: unique failure of bone marrow cells to induce prolonged skin allograft survival with anti-CD154 monoclonal antibody.
Academic Article	T cells facilitate Brugia malayi development in TCRalpha(null) mice.
Academic Article	Apoptosis and the thymic microenvironment in murine lupus.
Academic Article	Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article	An assay for human hematopoietic stem cells based on transplantation into nonobese diabetic recombination activating gene-null perforin-null mice.
Academic Article	The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.
Academic Article	Human cord blood--derived cells generate insulin-producing cells in vivo.
Academic Article	NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.
Academic Article	B1 B lymphocytes play a critical role in host protection against lymphatic filarial parasites.
Academic Article	TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1.
Academic Article	Humanized mice: are we there yet?
Academic Article	Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion.
Academic Article	Isolation of permanent clonal bone marrow stromal cell lines derived from "viable moth-eaten" and "severe combined immunodeficiency" mutant mice.
Academic Article	Targeting gastrin-releasing peptide receptors on small cell lung cancer cells with a bispecific molecule that activates polyclonal T lymphocytes.
Academic Article	Effect of ex vivo cytokine treatment on human cord blood engraftment in NOD-scid mice.
Academic Article	Role of gamma interferon and interleukin-4 in host defense against the human filarial parasite Brugia malayi.
Academic Article	beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell function.
Academic Article	Intramedullary and extramedullary B lymphopoiesis in osteopetrotic mice.
Academic Article	Transplantation analysis of B cell destruction in (NOD x CBA)F1 mouse bone marrow chimeras.
Academic Article	Effects of macrophage-colony-stimulating factor deficiency on the maturation of microglia and brain macrophages and on their expression of scavenger receptor.
Academic Article	Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice.
Academic Article	Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice.
Academic Article	Classification, clinical manifestations, and immunopathological mechanisms of the epithelial variant of paraneoplastic autoimmune multiorgan syndrome: a reappraisal of paraneoplastic pemphigus.
Academic Article	Rat xenograft survival in mice treated with donor-specific transfusion and anti-CD154 antibody is enhanced by elimination of host CD4+ cells.
Academic Article	Humanized NOD/LtSz-scid IL2 receptor common gamma chain knockout mice in diabetes research.
Academic Article	Spontaneous mutations in the mouse Sharpin gene result in multiorgan inflammation, immune system dysregulation and dermatitis.
Academic Article	Different mechanisms control peripheral and central tolerance in hematopoietic chimeric mice.
Academic Article	The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways.
Academic Article	Effect of aging on epidermal dendritic cell populations in C57BL/6J mice.
Academic Article	Creation of "humanized" mice to study human immunity.
Academic Article	Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses.
Academic Article	In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties.
Academic Article	Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.
Academic Article	The mouse mutant "motheaten". I. Development of lymphocyte populations.
Academic Article	The mouse mutant "motheaten." II. Functional studies of the immune system.
Academic Article	Idd loci synergize to prolong islet allograft survival induced by costimulation blockade in NOD mice.
Academic Article	Cancer stem cells are enriched in the side population cells in a mouse model of glioma.
Academic Article	Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice.
Academic Article	Lymphohemopoiesis in culture is prevented by interaction with adherent bone marrow cells from mutant viable motheaten mice.
Academic Article	Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.
Academic Article	Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.
Academic Article	Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.
Academic Article	In vivo selection of human embryonic stem cell-derived cells expressing methotrexate-resistant dihydrofolate reductase.
Academic Article	Interleukin-4 receptor-Stat6 signaling in murine infections with a tissue-dwelling nematode parasite.
Academic Article	Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.
Academic Article	Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' mice.
Academic Article	T cell developmental defects in 'viable motheaten' mice deficient in SHP-1 protein-tyrosine phosphatase. Developmental defects are corrected in vitro in the presence of normal hematopoietic-origin stromal cells and in vivo by exogenous IL-7.
Academic Article	Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.
Academic Article	Defective in vitro migratory capacity of bone marrow cells from viable motheaten mice in response to normal thymus culture supernatants.
Academic Article	Opportunistic bacterial infections in breeding colonies of the NSG mouse strain.
Academic Article	Zoledronic acid potentiates mTOR inhibition and abolishes the resistance of osteosarcoma cells to RAD001 (Everolimus): pivotal role of the prenylation process.
Academic Article	Granuloma formation around filarial larvae triggered by host responses to an excretory/secretory antigen.
Academic Article	Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model.
Academic Article	Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers.
Academic Article	Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2r? null mice is enhanced by transgenic expression of membrane-bound human SCF.
Academic Article	Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.
Academic Article	Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.
Academic Article	Antibody repertoires in humanized NOD-scid-IL2R?(null) mice and human B cells reveals human-like diversification and tolerance checkpoints in the mouse.
Academic Article	Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma.
Academic Article	In vitro and in vivo hematopoietic potential of human stem cells residing in muscle tissue.
Academic Article	Establishment and characterization of a new osteogenic cell line (MOS-J) from a spontaneous C57BL/6J mouse osteosarcoma.
Academic Article	Increased frequency of pre-pro B cells in the bone marrow of New Zealand Black (NZB) mice: implications for a developmental block in B cell differentiation.
Academic Article	GLI1 regulates a novel neuropilin-2/a6?1 integrin based autocrine pathway that contributes to breast cancer initiation.
Academic Article	Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice.
Academic Article	Gene for ovarian granulosa cell tumor susceptibility, Gct, in SWXJ recombinant inbred strains of mice revealed by dehydroepiandrosterone.
Academic Article	Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice.
Academic Article	Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.
Academic Article	T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.
Academic Article	Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article	Regulation of human short-term repopulating cell (STRC) engraftment in NOD/SCID mice by host CD122+ cells.
Academic Article	Alloimmune injury and rejection of human skin grafts on human peripheral blood lymphocyte-reconstituted non-obese diabetic severe combined immunodeficient beta2-microglobulin-null mice.
Academic Article	NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.
Academic Article	Hairpatches, a single gene mutation characterized by progressive renal disease and alopecia in the mouse. A potential model for a newly described heritable human disorder.
Academic Article	Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha.
Academic Article	The effect of immunosuppression on streptozotocin-induced diabetes in C57BL/KsJ mice.
Academic Article	Immunodeficiency and reticulum cell sarcoma in mice segregating for HRS/J and SJL/J genes.
Academic Article	"Viable motheaten," a new allele at the motheaten locus. I. Pathology.
Academic Article	Transgenic mice expressing either bovine growth hormone (bGH) or human GH releasing hormone (hGRH) have increased splenic progenitor cell colony formation and DNA synthesis in vitro and in vivo.
Academic Article	High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice.
Academic Article	The flaky skin (fsn) mutation in mice: map location and description of the anemia.
Academic Article	Emv30null NOD-scid mice. An improved host for adoptive transfer of autoimmune diabetes and growth of human lymphohematopoietic cells.
Academic Article	Cellular origin of follicular dendritic cells.
Academic Article	Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice.
Academic Article	Human bone marrow and umbilical cord blood cells generate CD4+ and CD8+ single-positive T cells in murine fetal thymus organ culture.
Academic Article	CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article	Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice.
Academic Article	Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donors.
Academic Article	Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
Academic Article	Cellular requirements for functional reconstitution of follicular dendritic cells in SCID mice.
Academic Article	Epidermal dendritic cell populations in the flaky skin mutant mouse.
Academic Article	Abnormal differentiation of tissue macrophage populations in 'osteopetrosis' (op) mice defective in the production of macrophage colony-stimulating factor.
Academic Article	Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article	Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.
Academic Article	Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells.
Academic Article	SHP-1 regulates STAT6 phosphorylation and IL-4-mediated function in a cell type-specific manner.
Academic Article	Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article	Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.
Academic Article	Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.
Academic Article	Efficient engraftment of primary adult T-cell leukemia cells in newborn NOD/SCID/beta2-microglobulin(null) mice.
Academic Article	Accelerated wound healing of alkali-burned corneas in MRL mice is associated with a reduced inflammatory signature.
Academic Article	TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.
Academic Article	The leukotriene B4 receptor (BLT1) is required for effector CD8+ T cell-mediated, mast cell-dependent airway hyperresponsiveness.
Academic Article	Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.
Academic Article	The SCID-hu mouse and thyroid autoimmunity: characterization of human thyroid autoantibody secretion.
Academic Article	Treatment and transfer of emphysema by a new bone marrow transplantation method from normal mice to Tsk mice and vice versa.
Academic Article	Anti-mouse CD154 antibody treatment facilitates generation of mixed xenogeneic rat hematopoietic chimerism, prevents wasting disease and prolongs xenograft survival in mice.
Academic Article	In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models.
Academic Article	Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.
Academic Article	Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article	Acute but not chronic macrophage recruitment in filarial infections in mice is dependent on C-C chemokine ligand 2.
Academic Article	Determinants of memory in experimental filarial infections in mice.
Academic Article	A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.
Academic Article	CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL.
Academic Article	Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice.
Academic Article	Humanized SCID mouse models for biomedical research.
Academic Article	A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
Academic Article	Expanded CD34+ human umbilical cord blood cells generate multiple lymphohematopoietic lineages in NOD-scid IL2rgamma(null) mice.
Academic Article	Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.
Academic Article	T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.
Academic Article	Human BLyS facilitates engraftment of human PBL derived B cells in immunodeficient mice.
Academic Article	TLR agonists prevent the establishment of allogeneic hematopoietic chimerism in mice treated with costimulation blockade.
Academic Article	Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article	Bioluminescent imaging demonstrates that transplanted human embryonic stem cell-derived CD34(+) cells preferentially develop into endothelial cells.
Academic Article	Identification of Pneumocystis carinii in immunodeficient mice.
Academic Article	The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.
Academic Article	Development of novel major histocompatibility complex class I and class II-deficient NOD-SCID IL2R gamma chain knockout mice for modeling human xenogeneic graft-versus-host disease.
Academic Article	Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice.
Academic Article	NOD-scid IL2rgamma(null) mouse model of human skin transplantation and allograft rejection.
Academic Article	Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.
Academic Article	Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.
Academic Article	High frequencies of leukemia stem cells in poor-outcome childhood precursor-B acute lymphoblastic leukemias.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Outbreaks of Pneumocystis carinii pneumonia in colonies of immunodeficient mice.
Academic Article	A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
Academic Article	Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2r?null Ins2Akita mice.
Academic Article	Human peripheral blood CD4 T cell-engrafted non-obese diabetic-scid IL2r?(null) H2-Ab1 (tm1Gru) Tg (human leucocyte antigen D-related 4) mice: a mouse model of human allogeneic graft-versus-host disease.
Academic Article	Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev).
Academic Article	Humanized mice as a preclinical tool for infectious disease and biomedical research.
Academic Article	Humanized mice for the study of type 1 and type 2 diabetes.
Academic Article	Ex?vivo fucosylation improves human cord blood engraftment in NOD-SCID IL-2R?(null) mice.
Academic Article	Advancing animal models of human type 1 diabetes by engraftment of functional human tissues in immunodeficient mice.
Academic Article	Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2r?KO mice.
Academic Article	Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
Academic Article	Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming.
Academic Article	Attenuation of exogenous murine mammary tumor virus virulence in the C3H/HeJ mouse substrain bearing the Lps mutation.
Academic Article	The immunological mouse mutants nude (nu) and rhino (hrrh) generate cytotoxic effector cells following adoptive immunotherapy but fail to reject a transplanted tumor.
Academic Article	Adenosine deaminase activity in recipients of bone marrow from immunodeficient mice homozygous for the wasted mutation.
Academic Article	Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transfer.
Academic Article	Effect of immunodeficiency on diabetogenesis in genetically diabetic (db/db) mice.
Academic Article	Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulins.
Academic Article	Mutations in mice that influence natural killer (NK) cell activity.
Academic Article	In the absence of a CD40 signal, B cells are tolerogenic.
Academic Article	Thymic epithelial cell abnormalities in (NZB x H-2u)F1 mice.
Academic Article	Maintenance of CD5+ B cells at an early developmental stage by interleukin-5: evidence from immunoglobulin gene usage in interleukin-5 transgenic mice.
Academic Article	Improved engraftment of human spleen cells in NOD/LtSz-scid/scid mice as compared with C.B-17-scid/scid mice.
Academic Article	Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.
Academic Article	Maintenance of the human malarial parasite, Plasmodium falciparum, in scid mice and transmission of gametocytes to mosquitoes.
Academic Article	B lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
Academic Article	Programmed differentiation of murine thymocytes during fetal thymus organ culture.
Academic Article	Antiviral activity of NK 1.1+ natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus.
Academic Article	Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathology.
Academic Article	Localization of prothymocytes from wild-type and viable motheaten mice following intravenous injection into irradiated adoptive recipients.
Academic Article	Ultrastructure of macrophages and dendritic cells in osteopetrosis (op) mutant mice lacking macrophage colony-stimulating factor (M-CSF/CSF-1) activity.
Academic Article	Effects of macrophage colony-stimulating factor (M-CSF) on the development, differentiation, and maturation of marginal metallophilic macrophages and marginal zone macrophages in the spleen of osteopetrosis (op) mutant mice lacking functional M-CSF activity.
Academic Article	The role of macrophage colony-stimulating factor in hepatic glucan-induced granuloma formation in the osteopetrosis mutant mouse defective in the production of macrophage colony-stimulating factor.
Academic Article	Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice.
Academic Article	Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes.
Academic Article	Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.
Academic Article	Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. Influence of B and T cells.
Concept	Mice, Inbred CBA
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred MRL lpr
Concept	Mice, Inbred C3H
Concept	Mice, Inbred SENCAR
Concept	Mice, Inbred ICR
Concept	Mice, Inbred C57BL
Concept	Mice, Inbred NOD
Concept	Mice, Inbred A
Concept	Mice, Inbred AKR
Concept	Mice, Inbred Strains
Concept	Mice, Inbred NZB
Concept	Mice, Inbred DBA
Academic Article	Engrafted human cells generate adaptive immune responses to Mycobacterium bovis BCG infection in humanized mice.
Academic Article	NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer.
Academic Article	Generation of ? cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice.
Academic Article	Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
Academic Article	MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.
Academic Article	The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Academic Article	Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.
Academic Article	P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.
Academic Article	Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance.
Academic Article	Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Academic Article	Induction of WT1-specific human CD8+ T cells from human HSCs in HLA class I Tg NOD/SCID/IL2rgKO mice.
Academic Article	Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells.
Academic Article	Genetically modified human CD4(+) T cells can be evaluated in?vivo without lethal graft-versus-host disease.
Academic Article	Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.
Academic Article	Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice.
Academic Article	Improved B cell development in humanized NOD-scid IL2R?null mice transgenically expressing human stem cell factor, granulocyte-macrophage colony-stimulating factor and interleukin-3.
Academic Article	Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Academic Article	Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
Academic Article	A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo.
Academic Article	mRNA-mediated glycoengineering ameliorates deficient homing of human stem cell-derived hematopoietic progenitors.
Academic Article	Age-dependent human ? cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.
Academic Article	Gene Therapy with an Adeno-Associated Viral Vector Expressing Human Interleukin-2 Alters Immune System Homeostasis in Humanized Mice.
Academic Article	Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression.
Academic Article	Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy.
Academic Article	Tissue-specific role of RHBDF2 in cutaneous wound healing and hyperproliferative skin disease.
Academic Article	Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic ? Cells for In?Vitro and In?Vivo Analysis.
Academic Article	A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation.
Academic Article	Human immune system development and survival of non-obese diabetic (NOD)-scid IL2r?(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.
Academic Article	Survival Advantage of Both Human Hepatocyte Xenografts and Genome-Edited Hepatocytes for Treatment of a-1 Antitrypsin Deficiency.
Academic Article	Human Anti-HIV-1 gp120 Monoclonal Antibodies with Neutralizing Activity Cloned from Humanized Mice Infected with HIV-1.
Academic Article	Co-activation of macrophages and T cells contribute to chronic GVHD in human IL-6 transgenic humanised mouse model.
Academic Article	Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.
Academic Article	Genome-wide Analysis of Salmonella enterica serovar Typhi in Humanized Mice Reveals Key Virulence Features.
Academic Article	Functional profiling of single CRISPR/Cas9-edited human long-term hematopoietic stem cells.
Academic Article	Dapagliflozin Does Not Directly Affect Human a or ? Cells.
Academic Article	A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic-related cytokine release syndrome.
Academic Article	Dual roles of neutrophils in metastatic colonization are governed by the host NK cell status.
Academic Article	Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
Academic Article	A novel clinically relevant graft-versus-leukemia model in humanized mice.
Academic Article	Novel phosphatidylserine-binding molecule enhances antitumor T-cell responses by targeting immunosuppressive exosomes in human tumor microenvironments.
Academic Article	Circulating CD34+?cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
Academic Article	Enhanced development of functional human NK cells in NOD-scid-IL2rgnull mice expressing human IL15.
Academic Article	NOD-scid IL2r?null mice lacking TLR4 support human immune system development and the study of human-specific innate immunity.
Academic Article	Human Hematopoietic Stem Cell Engrafted IL-15 Transgenic NSG Mice Support Robust NK Cell Responses and Sustained HIV-1 Infection.
Academic Article	Simultaneous evaluation of treatment efficacy and toxicity for bispecific T-cell engager therapeutics in a humanized mouse model.
Academic Article	Human insulin as both antigen and protector in type 1 diabetes.
Academic Article	Interruption of glucagon signaling augments islet non-alpha cell proliferation in SLC7A2- and mTOR-dependent manners.
Academic Article	Long-Term Human Immune Reconstitution, T-Cell Development, and Immune Reactivity in Mice Lacking the Murine Major Histocompatibility Complex: Validation with Cellular and Gene Expression Profiles.

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