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Search Results to Michael Paul Czech PhD

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Rotation Projects

Mentoring………………………………………………………………………………………………………

 The Czech laboratory is active in mentoring graduate students and postdoctoral fellows.

Many former student and postdoctoral trainees of the Czech laboratory are now internationally recognized professors at major universities and medical schools. These former lab members include:

Paul Pilch, Professor of Biochemistry, Boston University School of Medicine

Jeffrey Pessin, Professor and Director of the Diabetes Center, Einstein College of Medicine

Joan Massague,  Director, Sloan Kettering Institute

Roger Davis, HHMI investigator and Professor of Molecular Medicine, UMASS Medical School

Silvia Corvera, Professor of Molecular Medicine, Co-Director of the MD/PhD Program, UMASS Medical School

Carla Greenbaum, Vice Chair and Director of Clinical Research, Benaroya Research Institute

Jes Klarlund, Professor of Ophthalmology, University of Pittsburgh Medical Center

Rob Lewis, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center

Richard MacDonald, Professor of Biochemistry and Molecular Biology, Eppley Cancer Institute, University of Nebraska Medical Center

Assia Shisheva, Professor of Physiology, Wayne State School of Medicine.

Mark Sleeman, Professor of Physiology, Monash University, Australia

John Harris, Associate Professor of Medicine, UMASS Medical School

Zhen Jiang, Associate Professor of Pharmacology and Medicine, Boston University

Vishu Puri, Professor of Biomedical Sciences, Ohio University

Olga Gupta, Assistant Professor of Pediatrics and Medicine, University of Texas Southwestern Medical Center

Tim Fitzgibbons, Assistant Professor of Medicine, UMASS Medical School

Myriam Aouadi, Assistant Professor, Integrated Cardio Metabolic Centre, Karolinska Institute

Adilson Guilherme, Associate Professor, University of Massachusetts Medical School

 

Our laboratory currently offers graduate student Rotation Projects (examples below and others available) and Thesis Research Projects for students following a rotation:

Developing CRISPR technology for gene editing in adipocytes: Adipocytes function as master regulators of whole body metabolism and deletions of specific adipocyte genes in knockout mice promote dramatic improvements in glucose tolerance and insulin sensitivity in diabetic models. Thus the ability to direct gene editing in adipocytes in vivo has great potential in developing therapeutic strategies for obesity, type 2 diabetes and cardiovascular complications. Alternatively, an ex vivo approach is also feasible since adipose cells can be genetically altered in vitro prior to implantation into mice with beneficial effects. Such projects are designed to be performed in collaboration with other Czech lab members with the goal of specifically deleting or editing genes in adipose depots that drive increases in fatty acid oxidation, energy expenditure and systemic metabolic activity. Exciting preliminary data at the “proof of principle” stage has been achieved and this project is designed to focus on specific genes of high interest for therapeutics.

Signaling by the lipogenesis pathway through Acetyl CoA: A major function of adipocytes is to store calories as triglyceride, in part through the process of fatty acid synthesis (lipogenesis). This metabolic pathway involves a number of metabolites including Acetyl CoA, which is also a substrate for acetylation reactions that modify proteins such as histones. Thus metabolic flux through adipocyte lipogenesis may also function as a signaling pathway to the nucleus to modulate transcription via levels of Acetyl CoA that accumulate during this process. This rotation project is designed to test this idea at the molecular level by monitoring histone acetylations and resultant transcriptional events during changes in Acetyl CoA levels caused by altering physiological conditions such as exercise, obesity and diabetes. If this concept is correct, the project could lead to developing therapeutic strategies for metabolic disease based on targeting lipogenic enzymes.

 

 

 

 

 


One or more keywords matched the following items that are connected to Czech, Michael

Item TypeName
Academic Article Fat targets for insulin signaling.
Academic Article Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c.
Academic Article Dynamics of phosphoinositides in membrane retrieval and insertion.
Academic Article Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.
Academic Article RNAi-based analysis of CAP, Cbl, and CrkII function in the regulation of GLUT4 by insulin.
Academic Article An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Academic Article Structural determinants of phosphoinositide selectivity in splice variants of Grp1 family PH domains.
Academic Article Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes.
Academic Article Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T cells.
Academic Article Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha.
Academic Article PIP2 and PIP3: complex roles at the cell surface.
Academic Article The GLUT4 glucose transporter.
Academic Article Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.
Academic Article Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage.
Academic Article Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.
Academic Article Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.
Academic Article A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Academic Article Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells.
Academic Article Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4(+) T lymphocytes via an interleukin-2-dependent mechanism.
Academic Article A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
Academic Article Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes.
Academic Article A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling.
Academic Article Map4k4 negatively regulates peroxisome proliferator-activated receptor (PPAR) gamma protein translation by suppressing the mammalian target of rapamycin (mTOR) signaling pathway in cultured adipocytes.
Academic Article Partial lipodystrophy and insulin resistant diabetes in a patient with a homozygous nonsense mutation in CIDEC.
Academic Article Identification of the lipid droplet targeting domain of the Cidea protein.
Academic Article Regulation of fat specific protein 27 by isoproterenol and TNF-a to control lipolysis in murine adipocytes.
Academic Article Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation.
Academic Article C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane.
Academic Article Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.
Academic Article Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.
Academic Article Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.
Academic Article Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.
Academic Article Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules.
Academic Article Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing.
Academic Article Insulin's expanding control of forkheads.
Academic Article EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
Academic Article Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway.
Academic Article Micromanaging insulin secretion.
Academic Article Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
Academic Article PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.
Academic Article The v-SNARE Vti1a regulates insulin-stimulated glucose transport and Acrp30 secretion in 3T3-L1 adipocytes.
Academic Article Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.
Academic Article An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport.
Academic Article RNAi-based gene silencing in primary mouse and human adipose tissues.
Academic Article The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.
Academic Article Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors.
Academic Article Cidea is associated with lipid droplets and insulin sensitivity in humans.
Academic Article Lipid droplets: FSP27 knockout enhances their sizzle.
Academic Article Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation.
Academic Article A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes.
Academic Article Dicer is required for the formation of white but not brown adipose tissue.
Academic Article Coronin 2A mediates actin-dependent de-repression of inflammatory response genes.
Academic Article Obesity Notches up fatty liver.
Academic Article Map4k4 suppresses Srebp-1 and adipocyte lipogenesis independent of JNK signaling.
Concept Vesicular Transport Proteins
Concept Membrane Proteins
Concept Protein Binding
Concept Protein Transport
Concept Early Growth Response Protein 2
Concept DNA-Binding Proteins
Concept CCAAT-Enhancer-Binding Protein-alpha
Concept Muscle Proteins
Concept Ubiquitin-Protein Ligases
Concept Qb-SNARE Proteins
Concept Mitogen-Activated Protein Kinases
Concept p38 Mitogen-Activated Protein Kinases
Concept Fatty Acid-Binding Proteins
Concept High Mobility Group Proteins
Concept Mitogen-Activated Protein Kinase Kinases
Concept Mitochondrial Proteins
Concept Mitogen-Activated Protein Kinase 1
Concept Carrier Proteins
Concept Sterol Regulatory Element Binding Protein 1
Concept Ribosomal Protein S6 Kinases, 70-kDa
Concept Cell Cycle Proteins
Concept Luminescent Proteins
Concept Nuclear Proteins
Concept Recombinant Proteins
Concept Protein Kinases
Concept Protein-Serine-Threonine Kinases
Concept AMP-Activated Protein Kinases
Concept Intracellular Signaling Peptides and Proteins
Concept Mitogen-Activated Protein Kinase 3
Concept Wiskott-Aldrich Syndrome Protein, Neuronal
Concept Intercellular Signaling Peptides and Proteins
Concept Repressor Proteins
Concept Protein Kinase C
Concept CCAAT-Enhancer-Binding Protein-beta
Concept Proto-Oncogene Proteins c-akt
Concept Proteins
Concept Cytoskeletal Proteins
Concept Protein Structure, Tertiary
Concept Adaptor Proteins, Signal Transducing
Concept Monosaccharide Transport Proteins
Concept Oncogene Protein v-akt
Concept Green Fluorescent Proteins
Concept Bacterial Proteins
Concept Recombinant Fusion Proteins
Concept Proto-Oncogene Proteins c-cbl
Concept Protein Stability
Concept Protein Tyrosine Phosphatases
Concept Fungal Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Proto-Oncogene Proteins c-jun
Concept Neoplasm Proteins
Concept Caenorhabditis elegans Proteins
Concept Drosophila Proteins
Concept Microfilament Proteins
Concept Actin-Related Protein 2
Concept JNK Mitogen-Activated Protein Kinases
Concept Fatty Acid Transport Proteins
Concept Calcium-Calmodulin-Dependent Protein Kinase Type 2
Concept Actin-Related Protein 3
Concept Molecular Motor Proteins
Concept Apoptosis Regulatory Proteins
Concept Proto-Oncogene Proteins
Concept Blood Proteins
Concept Proto-Oncogene Proteins c-crk
Concept GTPase-Activating Proteins
Concept Nerve Tissue Proteins
Concept Tumor Suppressor Proteins
Academic Article The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila.
Academic Article The Lipid Droplet Protein Hypoxia-inducible Gene 2 Promotes Hepatic Triglyceride Deposition by Inhibiting Lipolysis.
Academic Article Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues.
Academic Article Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis.
Academic Article Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.
Academic Article Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.
Academic Article Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.
Academic Article CRISPR delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure.
Academic Article Joint analysis of left ventricular expression and circulating plasma levels of Omentin after myocardial ischemia.

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  • GTP Binding Proteins