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One or more keywords matched the following properties of Mordes, John
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John Morder, MDBoard CertificationAmerican Board of Internal Medicine
American Board of IM-Endocrinology, Diabetes, Meta
Medical DegreeHarvard Medical School
Boston Massachusetts
Residency/TrainingBrigham & Women's Hospital
Massachusetts Mental Health Center
FellowshipUMass Memorial Medical Center

Research

Our laboratory conducts basic and clinical research in the area of type 1 diabetes. Basic research is currently focused on the genetics and pathophysiology of diabetes in rat models of the disease with particular emphasis on the T cell receptor beta chain and the diubiquitin gene. We are also in the early stages of a program designed to understand the mechanisms underlying type 1 diabetes following viral infection. Another program is studying the susceptibility of certain rats to multiple disorders including diabetes, arthritis, and thyroiditis. Finally, we are also participating in clinical studies of otelixizumab, an anti-CD3 monoclonal antibody currently in phase 3 trials in adolescents and adults with new onset type 1 diabetes and in clinical studies of non-invasive methods for measuring glucose concentration.

One or more keywords matched the following items that are connected to Mordes, John
Item TypeName
Academic Article NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article Induction of tolerance for islet transplantation for type 1 diabetes.
Academic Article Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Academic Article Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Academic Article TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Academic Article Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.
Academic Article Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
Academic Article Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: V?13 as a therapeutic target and biomarker.
Academic Article Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project.
Academic Article Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Academic Article Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Academic Article Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
Academic Article Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation.
Academic Article A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
Academic Article Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
Academic Article A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.
Academic Article Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Academic Article Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.
Academic Article Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
Concept Diabetes Mellitus, Type 2
Concept Diabetes Mellitus, Type 1
Academic Article Autoantigen-induced focusing of V?13+ T cells precedes onset of autoimmune diabetes in the LEW.1WR1 rat.
Academic Article Management status and its predictive factors in patients with type 2 diabetes in China: A Nationwide Multicenter Study: A Nationwide Multicenter Study.
Academic Article A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
Academic Article Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.
Academic Article Comparing the effects of 6 months aerobic exercise and resistance training on metabolic control and ?-cell function in Chinese patients with prediabetes: A multicenter randomized controlled trial.
Academic Article T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.
Search Criteria
  • Diabetes Mellitus Type 1