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Mordes, John

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overview

	Board Certification	American Board of Internal Medicine American Board of IM-Endocrinology, Diabetes, Meta
	Medical Degree	Harvard Medical School Boston Massachusetts
	Residency/Training	Brigham & Women's Hospital Massachusetts Mental Health Center
	Fellowship	UMass Memorial Medical Center

Research

Our laboratory conducts basic and clinical research in the area of type 1 diabetes. Basic research is currently focused on the genetics and pathophysiology of diabetes in rat models of the disease with particular emphasis on the T cell receptor beta chain and the diubiquitin gene. We are also in the early stages of a program designed to understand the mechanisms underlying type 1 diabetes following viral infection. Another program is studying the susceptibility of certain rats to multiple disorders including diabetes, arthritis, and thyroiditis. Finally, we are also participating in clinical studies of otelixizumab, an anti-CD3 monoclonal antibody currently in phase 3 trials in adolescents and adults with new onset type 1 diabetes and in clinical studies of non-invasive methods for measuring glucose concentration.

One or more keywords matched the following items that are connected to Mordes, John

Item Type	Name
Academic Article	Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.
Academic Article	Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats.
Academic Article	Anti-endothelial cell autoantibodies in BB rats with spontaneous and induced IDDM.
Academic Article	Induction of insulin-dependent diabetes mellitus in PVG.RT1u rats.
Academic Article	The T cell marker RT6 in a rat model of autoimmune diabetes.
Academic Article	High frequency apoptosis of recent thymic emigrants in the liver of lymphopenic diabetes-prone BioBreeding rats.
Academic Article	Induction of immunological tolerance to islet allografts.
Academic Article	Induction of islet transplantation tolerance using donor specific transfusion and anti-CD154 monoclonal antibody.
Academic Article	Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture.
Academic Article	NOD mice have a generalized defect in their response to transplantation tolerance induction.
Academic Article	Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4.
Academic Article	The rat T-cell surface protein RT6 is associated with src family tyrosine kinases and generates an activation signal.
Academic Article	The BB/Wor rat and the balance hypothesis of autoimmunity.
Academic Article	Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat.
Academic Article	Altered expression of diabetes in BB/Wor rats by exposure to viral pathogens.
Academic Article	NOD congenic mice genetically protected from autoimmune diabetes remain resistant to transplantation tolerance induction.
Academic Article	Induction of tolerance for islet transplantation for type 1 diabetes.
Academic Article	Non-major histocompatibility complex-linked diabetes susceptibility loci on chromosomes 4 and 13 in a backcross of the DP-BB/Wor rat to the WF rat.
Academic Article	Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Academic Article	Intravital dye-labeled diabetogenic rat T cells retain dye, home to the pancreas, and induce diabetes.
Academic Article	Islet allograft survival induced by costimulation blockade in NOD mice is controlled by allelic variants of Idd3.
Academic Article	Insulin dependent diabetes mellitus hypothesis of autoimmunity.
Academic Article	The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection.
Academic Article	Diabetes prone BB rats are severely deficient in natural killer T cells.
Academic Article	Costimulation and autoimmune diabetes in BB rats.
Academic Article	TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat.
Academic Article	Fetal thymi from diabetes-prone but not diabetes-resistant BB/Wor rats fail to generate mature ART2+ T-cells in organ culture.
Academic Article	BB rat thymocytes cultured in the presence of islets lose their ability to transfer autoimmune diabetes.
Academic Article	Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere.
Academic Article	The effect of ciamexone on lymphocytic thyroiditis and insulin-dependent diabetes mellitus in the BB/Wor rat.
Academic Article	Virus-induced autoimmune diabetes in the LEW.1WR1 rat requires Iddm14 and a genetic locus proximal to the major histocompatibility complex.
Academic Article	Levels of Art2+ cells but not soluble Art2 protein correlate with expression of autoimmune diabetes in the BB rat.
Academic Article	Infection with viruses from several families triggers autoimmune diabetes in LEW*1WR1 rats: prevention of diabetes by maternal immunization.
Academic Article	The pathogenesis of autoimmune diabetes mellitus.
Academic Article	Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: V?13 as a therapeutic target and biomarker.
Academic Article	Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project.
Academic Article	T-lymphocyte requirement for diabetes in RT6-depleted diabetes-resistant BB rats.
Academic Article	The iddm4 locus segregates with diabetes susceptibility in congenic WF.iddm4 rats.
Academic Article	Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat.
Academic Article	Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations.
Academic Article	Approaches to prevention and treatment of IDDM in animal models.
Academic Article	Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.
Academic Article	Genetic disassociation of autoimmunity and resistance to costimulation blockade-induced transplantation tolerance in nonobese diabetic mice.
Academic Article	Hormonal and environmental factors in the pathogenesis of BB rat diabetes.
Academic Article	Failure to transfer insulitis to athymic recipients using BB/W rat lymphoid tissue transplants.
Academic Article	Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat.
Academic Article	Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat.
Academic Article	Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats.
Academic Article	An RT6a gene is transcribed and translated in lymphopenic diabetes-prone BB rats.
Academic Article	Adoptive transfer of autoimmune diabetes mellitus to athymic rats: synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells.
Academic Article	Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats.
Academic Article	Evidence that intrathymic islet transplantation does not prevent diabetes or subsequent islet graft destruction in RT6-depleted, diabetes-resistant BioBreeding/Worcester rats.
Academic Article	T lymphocytes capable of activating endothelial cells in vitro are present in rats with autoimmune diabetes.
Academic Article	Deficiencies in gut NK cell number and function precede diabetes onset in BB rats.
Academic Article	Prolonged survival of neonatal porcine islet xenografts in mice treated with a donor-specific transfusion and anti-CD154 antibody.
Academic Article	Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
Academic Article	Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice.
Academic Article	A regulatory CD4+ T cell subset in the BB rat model of autoimmune diabetes expresses neither CD25 nor Foxp3.
Academic Article	Development of new-generation HU-PBMC-NOD/SCID mice to study human islet alloreactivity.
Academic Article	Refinement of the Iddm4 diabetes susceptibility locus reveals TCRVbeta4 as a candidate gene.
Academic Article	A novel susceptibility locus on rat chromosome 8 affects spontaneous but not experimentally induced type 1 diabetes.
Academic Article	The BB rat as a model of human insulin-dependent diabetes mellitus.
Academic Article	Analysis of the rat Iddm14 diabetes susceptibility locus in multiple rat strains: identification of a susceptibility haplotype in the Tcrb-V locus.
Academic Article	Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.
Academic Article	Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.
Academic Article	Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats.
Academic Article	Prevention of diabetes in BB/Wor rat by single transfusion of spleen cells. Parameters that affect degree of protection.
Academic Article	Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes.
Academic Article	Regulatory T cell control of autoimmune destruction of beta cells in the BB rat.
Academic Article	Speculations on etiology of diabetes mellitus. Tumbler hypothesis.
Academic Article	Diabetes in the Bio-Breeding/Worcester rat. Induction and acceleration by spleen cell-conditioned media.
Academic Article	DR-BB rat thymus contains thymocyte populations predisposed to autoreactivity.
Academic Article	Human autoimmune diabetes mellitus: lessons from BB rats and NOD mice--Caveat emptor.
Academic Article	Cytolysin gene expression in the islets of diabetic BioBreeding/Worcester rats.
Academic Article	Pancreas-specific venular labeling by monastral blue B in the BB rat: modulation by prostaglandins and their inhibitors.
Concept	Diabetes Mellitus, Type 2
Concept	Diabetes Mellitus, Type 1
Academic Article	Autoantigen-induced focusing of V?13+ T cells precedes onset of autoimmune diabetes in the LEW.1WR1 rat.
Academic Article	Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.
Academic Article	Management status and its predictive factors in patients with type 2 diabetes in China: A Nationwide Multicenter Study: A Nationwide Multicenter Study.
Academic Article	A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats.
Academic Article	Autoimmunity after islet-cell allotransplantation.
Academic Article	Genetic Variation Within the HLA-DRA1 Gene Modulates Susceptibility to Type 1 Diabetes in HLA-DR3 Homozygotes.
Academic Article	Comparing the effects of 6 months aerobic exercise and resistance training on metabolic control and ?-cell function in Chinese patients with prediabetes: A multicenter randomized controlled trial.
Academic Article	T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes.

Search Criteria

Diabetes Mellitus Type 2