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Marinus, Martin
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Academic Background

B.Sc.(Hons.), 1965, PhD, Otago, New Zealand, 1968
American Cancer Society Faculty Research Award, 1976-1981
Visiting Professor, University of Sussex, UK 1980-1981
Erskine Fellow, University of Canterbury, NZ 1991
Visiting Professor, University of Goettingen, Germany 1996-1997
Visiting Professor, Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette 2006

http://www.drug-resistance.net/

Biology of Enterohemorrhagic Escherichia coli O157:H7 and Enterovirus 933W.
  Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is among the leading causes of food- and water-borne illnesses affecting humans in the U.S., Europe, and Japan. Although most EHEC infections resolve spontaneously after 5-10 days of abdominal cramping and bloody diarrhea, approximately 2-7% of cases progress to the potentially fatal hemolytic uremic syndrome due, in part, to the production of cytotoxic Shiga toxins which are capable of promoting kidney failure.
 We found that resistance to certain antibiotics in E. coli O157:H7 occurs at a higher frequency than in E. coli K-12. The mutation responsible is in the mar (multiple antibiotic resistance) genes. The molecular basis for the higher mutation rate in these genes is still unknown.
 In EHEC strain EDL933, the genes (stx2AB) encoding Shiga toxin are located on prophage 933W in the late region between genes Q and S and are transcribed with the late region genes from promoter PR’. Previous work showed that the ends of the genome in a free phage population could not be sequenced suggesting that they are terminally redundant. If so, then 933W should be able to carry out transduction of host genes from one bacterium to another. We showed that, indeed, this is the case thereby providing another way to transfer genetic material among EHEC strains.Current work includes using 933W as an indicator of SOS induction.

Formation of F-actin in HeLa cells by Escherichia coli 0157:H7. A HeLa cell infected with dam mutant bacteria of E. coli 0157:H7 is shown stained with DAPI (bacteria), filamentous actin stain (pedestals) and a merged image.

Owing to circumstances beyond my control, bacterial strains and plasmids are no longer available. Please contact the E. coli Genetic Stock Center which may be able to help you with bacterial strains. Addgene may be able to provide plasmids.

Microarray AnalysisMicroarray results show that global gene expression in a seqA mutant strain (left panel) is the same as that in a wildtype strain overproducing the Dam methyltransferase (center panel) but that neither is similar to that for the dam mutant (right panel).
One or more keywords matched the following items that are connected to Marinus, Martin
Item TypeName
Academic Article Dominant negative mutator mutations in the mutL gene of Escherichia coli.
Academic Article Levels of epsilon, an essential replication subunit of Escherichia coli DNA polymerase III, are controlled by heat shock proteins.
Academic Article Deletion mutation analysis of the mutS gene in Escherichia coli.
Academic Article Pleiotropic effects of a DNA adenine methylation mutation (dam-3) in Escherichia coli K12.
Academic Article Escherichia coli mutator genes.
Academic Article Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli.
Academic Article Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide.
Academic Article The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.
Academic Article The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein.
Academic Article DNA Mismatch Repair
Academic Article A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
Academic Article Role of plasmid multimers in mutation to tetracycline resistance.
Academic Article Regulated expression of the Escherichia coli dam gene.
Academic Article Spontaneous and cisplatin-induced recombination in Escherichia coli.
Academic Article MutS inhibits RecA-mediated strand exchange with platinated DNA substrates.
Academic Article Quantitation of Dam methyltransferase in Escherichia coli.
Academic Article Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant.
Academic Article Dam methylation: coordinating cellular processes.
Academic Article Cisplatin induces DNA double-strand break formation in Escherichia coli dam mutants.
Academic Article Recombination is essential for viability of an Escherichia coli dam (DNA adenine methyltransferase) mutant.
Academic Article Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli.
Academic Article Multiple pathways of recombination define cellular responses to cisplatin.
Academic Article Vegetative Replication and Transfer Replication of Deoxyribonucleic Acid in Temperature-Sensitive Mutants of Escherichia coli K-12.
Academic Article Identification of a weak promoter for the dam gene of Escherichia coli.
Academic Article The LipB protein is a negative regulator of dam gene expression in Escherichia coli.
Academic Article Mutational analysis of the MutH protein from Escherichia coli.
Academic Article Specificity of Escherichia coli mutD and mutL mutator strains.
Academic Article YhdJ, a nonessential CcrM-like DNA methyltransferase of Escherichia coli and Salmonella enterica.
Academic Article DNA mismatch repair-induced double-strand breaks.
Academic Article Dam methyltransferase is required for stable lysogeny of the Shiga toxin (Stx2)-encoding bacteriophage 933W of enterohemorrhagic Escherichia coli O157:H7.
Academic Article Expression of the Escherichia coli dam gene.
Academic Article Characterization of DNA adenine methylation mutants of Escherichia coli K12.
Academic Article DNA methylation and mutator genes in Escherichia coli K-12.
Academic Article The great GATC: DNA methylation in E. coli.
Academic Article Gene expression in E. coli after treatment with streptozotocin.
Academic Article Sequence specificity of streptozotocin-induced mutations.
Academic Article Role of SeqA and Dam in Escherichia coli gene expression: a global/microarray analysis.
Academic Article Spontaneous mutations occur near dam recognition sites in a dam- Escherichia coli host.
Academic Article Mutation spectrum in Escherichia coli DNA mismatch repair deficient (mutH) strain.
Academic Article DNA methylation in Escherichia coli.
Academic Article Direct role of the Escherichia coli Dam DNA methyltransferase in methylation-directed mismatch repair.
Academic Article DNA methylation influences trpR promoter activity in Escherichia coli K-12.
Academic Article Analysis of forward mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the bacteriophage P22 mnt repressor gene.
Academic Article Investigation of the mating system of Pseudomonas aeruginosa strain 1. 3. Kinetic studies on the transfer of the sex factor (FP).
Academic Article Insertion mutations in the dam gene of Escherichia coli K-12.
Academic Article Adenine methylation of Okazaki fragments in Escherichia coli.
Academic Article Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12.
Academic Article Induction of damage inducible (SOS) repair in dam mutants of Escherichia coli exposed to 2-aminopurine.
Academic Article Isolation and characterization of Dam+ revertants and suppressor mutations that modify secondary phenotypes of dam-3 strains of Escherichia coli K-12.
Academic Article Mismatch correction at O6-methylguanine residues in E. coli DNA.
Academic Article Growth-rate-dependent transcription initiation from the dam P2 promoter.
Academic Article Dominant negative mutator mutations in the mutS gene of Escherichia coli.
Academic Article The dam and dcm strains of Escherichia coli--a review.
Academic Article Repair of heteroduplex DNA molecules with multibase loops in Escherichia coli.
Academic Article DNA methylation alters the pattern of spontaneous mutation in Escherichia coli cells (mutD) defective in DNA polymerase III proofreading.
Academic Article Mutations produced by DNA polymerase III holoenzyme of Escherichia coli after in vitro synthesis in the absence of single-strand binding protein.
Academic Article MutS inhibits RecA-mediated strand transfer with methylated DNA substrates.
Academic Article Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli.
Academic Article The MutS C terminus is essential for mismatch repair activity in vivo.
Academic Article The beta sliding clamp binds to multiple sites within MutL and MutS.
Academic Article Homologous recombination prevents methylation-induced toxicity in Escherichia coli.
Academic Article Hda-mediated inactivation of the DnaA protein and dnaA gene autoregulation act in concert to ensure homeostatic maintenance of the Escherichia coli chromosome.
Academic Article Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7.
Academic Article DnaC inactivation in Escherichia coli K-12 induces the SOS response and expression of nucleotide biosynthesis genes.
Academic Article Roles of DNA adenine methylation in host-pathogen interactions: mismatch repair, transcriptional regulation, and more.
Academic Article DNA repair mechanisms affecting cytotoxicity by streptozotocin in E. coli.
Academic Article A simple and rapid method to obtain substitution mutations in Escherichia coli: isolation of a dam deletion/insertion mutation.
Academic Article Mutagenesis and repair of DNA damage caused by nitrogen mustard, N,N'-bis(2-chloroethyl)-N-nitrosourea (BCNU), streptozotocin, and mitomycin C in E. coli.
Academic Article The alkaloid compound harmane increases the lifespan of Caenorhabditis elegans during bacterial infection, by modulating the nematode's innate immune response.
Academic Article Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation.
Academic Article High efficiency generalized transduction in Escherichia coli O157:H7.
Academic Article High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.
Academic Article Arrangement of Dam methylation sites (GATC) in the Escherichia coli chromosome.
Academic Article Specificity of the Dam-directed mismatch repair system of Escherichia coli K-12.
Academic Article Studies on mutagenesis and repair induced by platinum analogs.
Academic Article Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.
Academic Article Viability of Escherichia coli K-12 DNA adenine methylase (dam) mutants requires increased expression of specific genes in the SOS regulon.
Academic Article Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12.
Academic Article Biological function for 6-methyladenine residues in the DNA of Escherichia coli K12.
Academic Article Investigation of the mating system of Pseudomonas aeruginosa strain 1. I. Kinetic studies.
Academic Article Investigation of the mating system of Pseudomonas aeruginosa strain 1. II. Mapping of a number of early markers.
Academic Article Regulation of isoleucine-valine biosynthesis in Pseudomonas aeruginosa. I. Characterisation and mapping of mutants.
Academic Article Regulation of isoleucine-valine biosynthesis in Pseudomonas aeruginosa. II. Regulation of enzyme activity and synthesis.
Academic Article Mutants of Pseudomonas aeruginosa bblocked in nitrate or nitrite dissimilation.
Academic Article Phenotypic reversal in dam mutants of Escherichia coli K-12 by a recombinant plasmid containing the dam+ gene.
Academic Article Hyper-recombination in dam mutants of Escherichia coli K-12.
Academic Article Influence of uvrD3, uvrE502, and recL152 mutations on the phenotypes of Escherichia coli K-12 dam mutants.
Academic Article Isolation and partial characterization of three Escherichia coli mutants with altered transfer ribonucleic acid methylases.
Academic Article Novel growth rate control of dam gene expression in Escherichia coli.
Academic Article Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli.
Concept Escherichia coli Infections
Concept Genes, Lethal
Concept Disease Models, Animal
Concept DNA Methylation
Concept N-Glycosyl Hydrolases
Concept Carbenicillin
Concept Temperature
Concept Platinum
Concept Endodeoxyribonucleases
Concept Feedback
Concept Heat-Shock Proteins
Concept Nitrates
Concept Escherichia coli K12
Concept Ultraviolet Rays
Concept Flow Cytometry
Concept HeLa Cells
Concept Exodeoxyribonucleases
Concept Colony Count, Microbial
Concept Cell Division
Concept Deoxyribonucleases, Type II Site-Specific
Concept Drug Resistance, Microbial
Concept Actins
Concept DNA Helicases
Concept Caenorhabditis elegans
Concept Carmustine
Concept Operator Regions, Genetic
Concept Catalysis
Concept Chromosomes, Bacterial
Concept Tetracycline Resistance
Concept Mitomycins
Concept Chromosomes
Concept Operon
Concept Genes, Dominant
Concept Genes, Viral
Concept Molecular Biology
Concept Open Reading Frames
Concept Genetic Complementation Test
Concept MutS DNA Mismatch-Binding Protein
Concept DNA Modification Methylases
Concept Carrier Proteins
Concept Replication Origin
Concept Genes
Concept Protease La
Concept DNA-(Apurinic or Apyrimidinic Site) Lyase
Concept Carbon Radioisotopes
Concept Trans-Activators
Concept Adenosine Triphosphate
Concept Amino Acid Sequence
Concept Shiga Toxin 2
Concept T-Phages
Concept Cisplatin
Concept Antineoplastic Agents
Concept Rifampin
Concept Lac Operon
Concept Culture Media
Concept Mitomycin
Concept Blotting, Western
Concept DNA Glycosylases
Concept Artificial Gene Fusion
Concept Codon, Initiator
Concept Chromatography, Gel
Concept Enzyme Induction
Concept Cell-Free System
Concept Tritium
Concept DNA Primers
Concept DNA Mismatch Repair
Concept Transcription, Genetic
Concept Repressor Proteins
Concept DNA Adducts
Concept Factor For Inversion Stimulation Protein
Concept Hot Temperature
Concept Codon
Concept Hydro-Lyases
Concept Drug Resistance, Multiple, Bacterial
Concept Receptor, Insulin
Concept DNA, Bacterial
Concept Escherichia coli
Concept Adaptor Proteins, Signal Transducing
Concept ATP-Dependent Proteases
Concept Genes, Bacterial
Concept Genes, Reporter
Concept Ribonuclease H
Concept Escherichia coli O157
Concept Bacteriophage lambda
Concept Catalytic Domain
Concept DNA Damage
Concept 2-Aminopurine
Concept Escherichia coli Proteins
Concept Radiation Genetics
Concept Green Fluorescent Proteins
Concept S-Adenosylmethionine
Concept Exodeoxyribonuclease V
Concept Response Elements
Concept Cross-Linking Reagents
Concept DNA Polymerase III
Concept Pseudomonas aeruginosa
Concept Carbon-Oxygen Lyases
Concept Salmonella enterica
Concept Caenorhabditis elegans Proteins
Concept Microbial Sensitivity Tests
Concept Nitrites
Concept Genetics, Microbial
Concept Sequence Homology, Amino Acid
Concept Thymidine
Concept DNA Replication
Concept Bacterial Infections
Concept Adenosine Triphosphatases
Concept DNA Restriction Enzymes
Concept Chlorates
Concept Carboplatin
Concept Serine Endopeptidases
Concept Chromosome Deletion
Concept beta-Galactosidase
Concept DNA Polymerase I
Concept DNA Repair
Concept Colon
Concept MAP Kinase Kinase 4
Concept Bacteriophage phi X 174
Concept Promoter Regions, Genetic
Concept Integration Host Factors
Concept Deoxyribonuclease IV (Phage T4-Induced)
Concept Gene Silencing
Concept Base Sequence
Concept Alleles
Concept Salmonella typhimurium
Concept Molecular Sequence Data
Concept DNA Transposable Elements
Concept Enterohemorrhagic Escherichia coli
Concept Ribosomes
Academic Article RecA-independent single-stranded DNA oligonucleotide-mediated mutagenesis.
Academic Article DNA Methylation.
Award or Honor Receipt Faculty Research Award
Academic Article DNA Methylation.
Concept MutL Proteins
Concept MutL Protein Homolog 1
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