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Marinus, Martin
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Academic Background

B.Sc.(Hons.), 1965, PhD, Otago, New Zealand, 1968
American Cancer Society Faculty Research Award, 1976-1981
Visiting Professor, University of Sussex, UK 1980-1981
Erskine Fellow, University of Canterbury, NZ 1991
Visiting Professor, University of Goettingen, Germany 1996-1997
Visiting Professor, Centre de Génétique Moléculaire, CNRS, Gif-sur-Yvette 2006

http://www.drug-resistance.net/

Biology of Enterohemorrhagic Escherichia coli O157:H7 and Enterovirus 933W.
  Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is among the leading causes of food- and water-borne illnesses affecting humans in the U.S., Europe, and Japan. Although most EHEC infections resolve spontaneously after 5-10 days of abdominal cramping and bloody diarrhea, approximately 2-7% of cases progress to the potentially fatal hemolytic uremic syndrome due, in part, to the production of cytotoxic Shiga toxins which are capable of promoting kidney failure.
 We found that resistance to certain antibiotics in E. coli O157:H7 occurs at a higher frequency than in E. coli K-12. The mutation responsible is in the mar (multiple antibiotic resistance) genes. The molecular basis for the higher mutation rate in these genes is still unknown.
 In EHEC strain EDL933, the genes (stx2AB) encoding Shiga toxin are located on prophage 933W in the late region between genes Q and S and are transcribed with the late region genes from promoter PR’. Previous work showed that the ends of the genome in a free phage population could not be sequenced suggesting that they are terminally redundant. If so, then 933W should be able to carry out transduction of host genes from one bacterium to another. We showed that, indeed, this is the case thereby providing another way to transfer genetic material among EHEC strains.Current work includes using 933W as an indicator of SOS induction.

Formation of F-actin in HeLa cells by Escherichia coli 0157:H7. A HeLa cell infected with dam mutant bacteria of E. coli 0157:H7 is shown stained with DAPI (bacteria), filamentous actin stain (pedestals) and a merged image.

Owing to circumstances beyond my control, bacterial strains and plasmids are no longer available. Please contact the E. coli Genetic Stock Center which may be able to help you with bacterial strains. Addgene may be able to provide plasmids.

Microarray AnalysisMicroarray results show that global gene expression in a seqA mutant strain (left panel) is the same as that in a wildtype strain overproducing the Dam methyltransferase (center panel) but that neither is similar to that for the dam mutant (right panel).
One or more keywords matched the following items that are connected to Marinus, Martin
Item TypeName
Academic Article Dominant negative mutator mutations in the mutL gene of Escherichia coli.
Academic Article Deletion mutation analysis of the mutS gene in Escherichia coli.
Academic Article Pleiotropic effects of a DNA adenine methylation mutation (dam-3) in Escherichia coli K12.
Academic Article Recombinational repair is critical for survival of Escherichia coli exposed to nitric oxide.
Academic Article The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.
Academic Article The function of Asp70, Glu77 and Lys79 in the Escherichia coli MutH protein.
Academic Article Role of plasmid multimers in mutation to tetracycline resistance.
Academic Article Regulated expression of the Escherichia coli dam gene.
Academic Article Separation of mutation avoidance and antirecombination functions in an Escherichia coli mutS mutant.
Academic Article Cisplatin induces DNA double-strand break formation in Escherichia coli dam mutants.
Academic Article Recombination is essential for viability of an Escherichia coli dam (DNA adenine methyltransferase) mutant.
Academic Article Analysis of global gene expression and double-strand-break formation in DNA adenine methyltransferase- and mismatch repair-deficient Escherichia coli.
Academic Article Multiple pathways of recombination define cellular responses to cisplatin.
Academic Article The LipB protein is a negative regulator of dam gene expression in Escherichia coli.
Academic Article Specificity of Escherichia coli mutD and mutL mutator strains.
Academic Article Expression of the Escherichia coli dam gene.
Academic Article Characterization of DNA adenine methylation mutants of Escherichia coli K12.
Academic Article DNA methylation and mutator genes in Escherichia coli K-12.
Academic Article Sequence specificity of streptozotocin-induced mutations.
Academic Article Spontaneous mutations occur near dam recognition sites in a dam- Escherichia coli host.
Academic Article Mutation spectrum in Escherichia coli DNA mismatch repair deficient (mutH) strain.
Academic Article Direct role of the Escherichia coli Dam DNA methyltransferase in methylation-directed mismatch repair.
Academic Article Analysis of forward mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the bacteriophage P22 mnt repressor gene.
Academic Article Insertion mutations in the dam gene of Escherichia coli K-12.
Academic Article Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12.
Academic Article Isolation and characterization of Dam+ revertants and suppressor mutations that modify secondary phenotypes of dam-3 strains of Escherichia coli K-12.
Academic Article Dominant negative mutator mutations in the mutS gene of Escherichia coli.
Academic Article The dam and dcm strains of Escherichia coli--a review.
Academic Article DNA methylation alters the pattern of spontaneous mutation in Escherichia coli cells (mutD) defective in DNA polymerase III proofreading.
Academic Article Mutations produced by DNA polymerase III holoenzyme of Escherichia coli after in vitro synthesis in the absence of single-strand binding protein.
Academic Article Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli.
Academic Article The MutS C terminus is essential for mismatch repair activity in vivo.
Academic Article Homologous recombination prevents methylation-induced toxicity in Escherichia coli.
Academic Article A simple and rapid method to obtain substitution mutations in Escherichia coli: isolation of a dam deletion/insertion mutation.
Academic Article High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.
Academic Article Specificity of the Dam-directed mismatch repair system of Escherichia coli K-12.
Academic Article Studies on mutagenesis and repair induced by platinum analogs.
Academic Article Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.
Academic Article Viability of Escherichia coli K-12 DNA adenine methylase (dam) mutants requires increased expression of specific genes in the SOS regulon.
Academic Article Isolation of deoxyribonucleic acid methylase mutants of Escherichia coli K-12.
Academic Article Biological function for 6-methyladenine residues in the DNA of Escherichia coli K12.
Academic Article Mutants of Pseudomonas aeruginosa bblocked in nitrate or nitrite dissimilation.
Academic Article Phenotypic reversal in dam mutants of Escherichia coli K-12 by a recombinant plasmid containing the dam+ gene.
Academic Article Hyper-recombination in dam mutants of Escherichia coli K-12.
Academic Article Influence of uvrD3, uvrE502, and recL152 mutations on the phenotypes of Escherichia coli K-12 dam mutants.
Academic Article Isolation and partial characterization of three Escherichia coli mutants with altered transfer ribonucleic acid methylases.
Academic Article Novel growth rate control of dam gene expression in Escherichia coli.
Academic Article Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli.
Concept Mutation
Concept Point Mutation
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