The focus of our research program is to delineate the molecular pathways that govern immune system development and function. We combine of variety experimental approaches, including human pluripotent stem cell differentiation, CRISPR-based (epi-)genome engineering, single cell RNAseq, computational biology and functional genomics, as well as various disease models to elucidate the molecular bases of human immune syndromes. The long-term goal is to recapitulate the disease in a patient-specific manner and to identify novel treatment strategies.