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Davis, Roger
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Rotation Projects

Rotation Projects

Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.
One or more keywords matched the following items that are connected to Davis, Roger
Item TypeName
Academic Article The JNK signal transduction pathway.
Academic Article Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Academic Article Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.
Academic Article Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line.
Academic Article Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Academic Article Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice.
Academic Article JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Academic Article Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.
Academic Article Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Academic Article The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation.
Academic Article A critical role of neural-specific JNK3 for ischemic apoptosis.
Academic Article JNK regulates autocrine expression of TGF-beta1.
Academic Article An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Academic Article c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
Academic Article ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Academic Article Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
Academic Article Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article Chemical genetic analysis of the time course of signal transduction by JNK.
Academic Article Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Academic Article Control of cellular senescence by CPEB.
Academic Article Metabolic stress signaling mediated by mixed-lineage kinases.
Academic Article Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Academic Article c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
Academic Article Multisite phosphorylation regulates Bim stability and apoptotic activity.
Academic Article Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Academic Article A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
Academic Article Induction of hepatitis by JNK-mediated expression of TNF-alpha.
Academic Article Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Academic Article Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Academic Article Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.
Academic Article c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal.
Academic Article Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
Academic Article Analysis of apoptosis of memory T cells and dendritic cells during the early stages of viral infection or exposure to toll-like receptor agonists.
Academic Article Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.
Academic Article c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.
Academic Article c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.
Academic Article Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
Academic Article Role of JNK in a Trp53-dependent mouse model of breast cancer.
Academic Article Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning.
Academic Article Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
Academic Article The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.
Academic Article Role of JNK in mammary gland development and breast cancer.
Academic Article JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Academic Article Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Academic Article c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Academic Article Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.
Academic Article JunD mediates survival signaling by the JNK signal transduction pathway.
Academic Article Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Academic Article Mechanism of p38 MAP kinase activation in vivo.
Academic Article The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
Academic Article Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2.
Academic Article The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Academic Article JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
Academic Article Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
Academic Article Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.
Academic Article JNK1 is required to preserve cardiac function in the early response to pressure overload.
Academic Article Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Academic Article JNK2 is a positive regulator of the cJun transcription factor.
Academic Article Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Academic Article c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.
Academic Article c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages.
Academic Article Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Academic Article Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.
Academic Article Analyzing mitogen-activated protein kinase (MAPK) activities in T cells.
Academic Article c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.
Academic Article Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Academic Article Prevention of steatosis by hepatic JNK1.
Academic Article Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation.
Academic Article AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Academic Article Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.
Academic Article JNK regulates FoxO-dependent autophagy in neurons.
Academic Article The role of JNK in the development of hepatocellular carcinoma.
Academic Article TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Academic Article Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Academic Article VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.
Academic Article JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation.
Academic Article ?1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.
Concept Mice, Inbred BALB C
Concept Mice, Knockout
Concept Mice
Concept Mice, Inbred C57BL
Concept Mice, Transgenic
Concept Mice, Inbred NOD
Concept Mice, Nude
Concept Mice, SCID
Concept Mice, Mutant Strains
Academic Article Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway.
Academic Article Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Academic Article p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene.
Academic Article The PPARa-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway.
Academic Article Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration.
Academic Article Pathological axonal death through a MAPK cascade that triggers a local energy deficit.
Academic Article Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.
Academic Article Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release.
Academic Article Prostate tumorigenesis induced by PTEN deletion involves estrogen receptor ? repression.
Academic Article Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.
Academic Article Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.
Academic Article Inflammation Mediated by JNK in Myeloid Cells Promotes the Development of Hepatitis and Hepatocellular Carcinoma.
Academic Article Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development.
Academic Article An alternative splicing program promotes adipose tissue thermogenesis.
Academic Article Melanoma mystery.
Academic Article A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Academic Article The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.
Academic Article The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation.
Academic Article JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.
Academic Article Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.
Academic Article Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Academic Article A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Academic Article Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
Academic Article Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.
Academic Article Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models.
Academic Article Regulation of adipose tissue inflammation by interleukin 6.
Academic Article A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21.
Academic Article JUN Amino-Terminal Kinase 1 Signaling in the Proximal Tubule Causes Cell Death and Acute Renal Failure in Rat and Mouse Models of Renal Ischemia/Reperfusion Injury.
Academic Article JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
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