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Academic Background

Dr. Roger J. Davis is an Investigator of the Howard Hughes Medical Institute and is the H. Arthur Smith Professor and Chair, Program in Molecular Medicine at the University of Massachusetts Medical School. He received his initial training as a student at Cambridge University.  He also trained as a Damon Runyon Cancer Research Foundation fellow with Michael P. Czech at the University of Massachusetts Medical School.  He subsequently joined the faculty of the University of Massachusetts Medical School and was a founding member of the Program in Molecular Medicine.

 

Dr. Davis’ studies of signal transduction mechanisms led to the molecular cloning of the first human stress-activated MAP kinase, the cJun NH2-terminal kinase (JNK).  Subsequent studies defined the molecular structure of the JNK pathway, including the identification of upstream and down-stream pathway components and scaffold proteins.  This signaling pathway is activated in response to many pathological / physiological stimuli and is implicated in inflammatory diseases (e.g. arthritis), cancer, stroke, heart disease, and diabetes.  The overall goal of Dr. Davis’ research is to understand the molecular basis for these diseases and to design novel therapeutic strategies.  

 

Dr. Davis has served as a Howard Hughes Medical Institute Investigator for 30 years.  He was identified as the most highly cited scientist world-wide in 1995-1996 by the Citation Index (Thompson Reuters) and is the author of more than 400 scientific papers.  He was elected to the National Academy of SciencesThe Royal SocietyAmerican Academy of MicrobiologyAmerican Association for the Advancement of SciencesNational Academy of Inventors, and the European Molecular Biology Organization.  He was also the recipient of the Steven C. Beering Award from Indiana University.  Dr. Davis was the Editor-in-Chief of the journal Molecular and Cellular Biology, and he currently serves on the Editorial Boards of eLifeGenes & Development, and Molecular Cell.  He also served as the Chair of the Cellular Aspects of Diabetes & Obesity Study Section (National Institutes of Health). 

 

Mechanisms by which growth factors regulate cellular proliferation

Photo: Roger DavisThe goal of this laboratory is to understand the molecular mechanism by which growth factors and cytokines regulate cellular proliferation and survival. A specific focus of our studies is to understand how MAP kinase signaling pathways, which are initiated at the cell surface, regulate the expression of genes in the nucleus.

These MAP kinase pathways include the extracellular signal-regulated kinases (ERKs), the c-Jun amino-terminal kinases (JNKs), and the p38 MAP kinases. The methods that we are using include recombinant DNA technology, protein chemistry, somatic cell genetics, and general biochemical techniques.

The significance of this research is that there are many disease states, such as cancer, that are characterized by abnormal cellular proliferation. A detailed understanding of the molecular processes involved in the control of cell growth is required for the design of rational treatments for these diseases.

Figure

Schematic diagram

Figure Legend

Schematic representation of the human MAP kinase signal transduction pathway network.

Rotation Projects

Rotation Projects

Laboratory rotations are available to study signal mammalian transduction mechanisms. Several projects are available, including studies of protein kinase cascades, gene expression, the cell cycle, and apoptosis. Targeted gene disruption approaches in mice combined with biochemical and molecular biology studies will be examined.


One or more keywords matched the following items that are connected to Davis, Roger

Item TypeName
Academic Article The JNK signal transduction pathway.
Academic Article Signal transduction by MAP kinases: regulation by phosphorylation-dependent switches.
Academic Article Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Academic Article The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Academic Article Murine Lyme arthritis development mediated by p38 mitogen-activated protein kinase activity.
Academic Article Signal transduction. MAP kinase signaling specificity.
Academic Article Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.
Academic Article Inhibition of the p38 pathway upregulates macrophage JNK and ERK activities, and the ERK, JNK, and p38 MAP kinase pathways are reprogrammed during differentiation of the murine myeloid M1 cell line.
Academic Article Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Academic Article Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3.
Academic Article Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice.
Academic Article Role of JNK in tumor development.
Academic Article JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Academic Article Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.
Academic Article Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Academic Article The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation.
Academic Article A critical role of neural-specific JNK3 for ischemic apoptosis.
Academic Article JNK regulates autocrine expression of TGF-beta1.
Academic Article An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Academic Article c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
Academic Article JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Academic Article ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Academic Article Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades.
Academic Article Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes.
Academic Article Chemical genetic analysis of the time course of signal transduction by JNK.
Academic Article Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Academic Article Signal transduction by the JNK group of MAP kinases.
Academic Article Control of cellular senescence by CPEB.
Academic Article Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Academic Article Proteins kinases: chromatin-associated enzymes?
Academic Article A radical role for p38 MAPK in tumor initiation.
Academic Article The JNK signal transduction pathway.
Academic Article Metabolic stress signaling mediated by mixed-lineage kinases.
Academic Article Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Academic Article c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection.
Academic Article Multisite phosphorylation regulates Bim stability and apoptotic activity.
Academic Article Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Academic Article A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
Academic Article Induction of hepatitis by JNK-mediated expression of TNF-alpha.
Academic Article Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Academic Article Analysis of c-Jun N-terminal kinase regulation and function.
Academic Article Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Academic Article Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.
Academic Article c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal.
Academic Article Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.
Academic Article MAP kinases in the immune response.
Academic Article Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.
Academic Article c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity.
Academic Article c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation.
Academic Article Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
Academic Article Role of JNK in a Trp53-dependent mouse model of breast cancer.
Academic Article Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning.
Academic Article Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
Academic Article The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.
Academic Article Role of JNK in mammary gland development and breast cancer.
Academic Article JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Academic Article Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.
Academic Article c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.
Academic Article The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor.
Academic Article JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
Academic Article Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Academic Article c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Academic Article Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury.
Academic Article Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.
Academic Article JunD mediates survival signaling by the JNK signal transduction pathway.
Academic Article Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Academic Article Mechanism of p38 MAP kinase activation in vivo.
Academic Article The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
Academic Article Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2.
Academic Article The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis.
Academic Article JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species.
Academic Article Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
Academic Article Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.
Academic Article JNK1 is required to preserve cardiac function in the early response to pressure overload.
Academic Article H2AX is a target of the JNK signaling pathway that is required for apoptotic DNA fragmentation.
Academic Article Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Academic Article JNK2 is a positive regulator of the cJun transcription factor.
Academic Article Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure.
Academic Article c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression.
Academic Article c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages.
Academic Article Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Academic Article Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Academic Article Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1.
Academic Article Analyzing mitogen-activated protein kinase (MAPK) activities in T cells.
Academic Article c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.
Academic Article Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Academic Article Prevention of steatosis by hepatic JNK1.
Academic Article Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation.
Academic Article JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint.
Academic Article cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance.
Academic Article AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Academic Article Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.
Academic Article JNK regulates FoxO-dependent autophagy in neurons.
Academic Article The role of JNK in the development of hepatocellular carcinoma.
Academic Article TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Academic Article Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Academic Article VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer.
Academic Article Cell biology. A scaffold switch to insulate.
Academic Article JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation.
Academic Article ß1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1.
Concept Protein-Tyrosine Kinases
Concept Protein Binding
Concept Protein Subunits
Concept Protein Transport
Concept Amyloid beta-Protein Precursor
Concept Agouti-Related Protein
Concept Tumor Suppressor Protein p14ARF
Concept Tumor Suppressor Protein p53
Concept Bone Morphogenetic Protein 7
Concept Mitogen-Activated Protein Kinases
Concept Calcium-Calmodulin-Dependent Protein Kinases
Concept p38 Mitogen-Activated Protein Kinases
Concept Mitogen-Activated Protein Kinase Kinases
Concept Protein Kinase Inhibitors
Concept Mitogen-Activated Protein Kinase 1
Concept Protein Biosynthesis
Concept Mitogen-Activated Protein Kinase 9
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Kinases
Concept bcl-2-Associated X Protein
Concept Protein-Serine-Threonine Kinases
Concept AMP-Activated Protein Kinases
Concept rhoA GTP-Binding Protein
Concept Survival of Motor Neuron 1 Protein
Concept Bone Morphogenetic Protein Receptors, Type II
Concept Mitogen-Activated Protein Kinase 3
Concept Protein Kinase C
Concept Fas-Associated Death Domain Protein
Concept Mitogen-Activated Protein Kinase 14
Concept Receptor-Interacting Protein Serine-Threonine Kinases
Concept Protein Structure, Secondary
Concept Protein Structure, Tertiary
Concept Mitogen-Activated Protein Kinase 11
Concept Cyclic AMP Response Element-Binding Protein
Concept Mitogen-Activated Protein Kinase 8
Concept Fas Ligand Protein
Concept JNK Mitogen-Activated Protein Kinases
Concept Protein Tyrosine Phosphatase, Non-Receptor Type 1
Concept Mitogen-Activated Protein Kinase 10
Concept Protein Isoforms
Concept Protein Conformation
Concept cdc42 GTP-Binding Protein
Concept Bone Morphogenetic Protein 2
Concept Bone Morphogenetic Protein 4
Concept bcl-2 Homologous Antagonist-Killer Protein
Academic Article The stress-activated protein kinases p38a/ß and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest.
Academic Article Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation.
Academic Article p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene.
Academic Article Bone marrow-derived c-jun N-terminal kinase-1 (JNK1) mediates liver regeneration.
Academic Article JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues.
Academic Article Presynaptic c-Jun N-terminal Kinase 2 regulates NMDA receptor-dependent glutamate release.
Academic Article Tead and AP1 Coordinate Transcription and Motility.
Academic Article TNFa-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38a MAPK Pathway.
Academic Article Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress.
Academic Article Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK.
Academic Article p38a MAPK is required for tooth morphogenesis and enamel secretion.
Academic Article Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.
Academic Article Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
Academic Article Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Academic Article A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Academic Article A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Academic Article JNK1/2 represses Lkb1-deficiency-induced lung squamous cell carcinoma progression.

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