Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Davis, Roger
PropertyValue
overview

Academic Background

Dr. Roger J. Davis is an Investigator of the Howard Hughes Medical Institute and is the H. Arthur Smith Professor and Chair, Program in Molecular Medicine at the University of Massachusetts Medical School. He received his initial training as a student at Cambridge University.  He also trained as a Damon Runyon Cancer Research Foundation fellow with Michael P. Czech at the University of Massachusetts Medical School.  He subsequently joined the faculty of the University of Massachusetts Medical School and was a founding member of the Program in Molecular Medicine.

 

Dr. Davis’ studies of signal transduction mechanisms led to the molecular cloning of the first human stress-activated MAP kinase, the cJun NH2-terminal kinase (JNK).  Subsequent studies defined the molecular structure of the JNK pathway, including the identification of upstream and down-stream pathway components and scaffold proteins.  This signaling pathway is activated in response to many pathological / physiological stimuli and is implicated in inflammatory diseases (e.g. arthritis), cancer, stroke, heart disease, and diabetes.  The overall goal of Dr. Davis’ research is to understand the molecular basis for these diseases and to design novel therapeutic strategies.  

 

Dr. Davis has served as a Howard Hughes Medical Institute Investigator for 30 years.  He was identified as the most highly cited scientist world-wide in 1995-1996 by the Citation Index (Thompson Reuters) and is the author of more than 400 scientific papers.  He was elected to the National Academy of SciencesThe Royal SocietyAmerican Academy of MicrobiologyAmerican Association for the Advancement of SciencesNational Academy of Inventors, and the European Molecular Biology Organization.  He was also the recipient of the Steven C. Beering Award from Indiana University.  Dr. Davis was the Editor-in-Chief of the journal Molecular and Cellular Biology, and he currently serves on the Editorial Boards of eLifeGenes & Development, and Molecular Cell.  He also served as the Chair of the Cellular Aspects of Diabetes & Obesity Study Section (National Institutes of Health). 

 

Mechanisms by which growth factors regulate cellular proliferation

Photo: Roger DavisThe goal of this laboratory is to understand the molecular mechanism by which growth factors and cytokines regulate cellular proliferation and survival. A specific focus of our studies is to understand how MAP kinase signaling pathways, which are initiated at the cell surface, regulate the expression of genes in the nucleus.

These MAP kinase pathways include the extracellular signal-regulated kinases (ERKs), the c-Jun amino-terminal kinases (JNKs), and the p38 MAP kinases. The methods that we are using include recombinant DNA technology, protein chemistry, somatic cell genetics, and general biochemical techniques.

The significance of this research is that there are many disease states, such as cancer, that are characterized by abnormal cellular proliferation. A detailed understanding of the molecular processes involved in the control of cell growth is required for the design of rational treatments for these diseases.

Figure

Schematic diagram

Figure Legend

Schematic representation of the human MAP kinase signal transduction pathway network.

One or more keywords matched the following items that are connected to Davis, Roger
Item TypeName
Academic Article Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases.
Academic Article The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase.
Academic Article Signal transduction. MAP kinase signaling specificity.
Academic Article Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.
Academic Article Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts.
Academic Article Role of JNK in tumor development.
Academic Article JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure.
Academic Article Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1.
Academic Article Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3).
Academic Article The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation.
Academic Article An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue.
Academic Article c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
Academic Article JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Academic Article ZPR1 is essential for survival and is required for localization of the survival motor neurons (SMN) protein to Cajal bodies.
Academic Article Deficiency of the zinc finger protein ZPR1 causes neurodegeneration.
Academic Article Control of cellular senescence by CPEB.
Academic Article Jun NH2-terminal kinase (JNK) prevents nuclear beta-catenin accumulation and regulates axis formation in Xenopus embryos.
Academic Article Proteins kinases: chromatin-associated enzymes?
Academic Article Metabolic stress signaling mediated by mixed-lineage kinases.
Academic Article Suppression of p53-dependent senescence by the JNK signal transduction pathway.
Academic Article Multisite phosphorylation regulates Bim stability and apoptotic activity.
Academic Article Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Academic Article A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.
Academic Article Mcl-1 integrates the opposing actions of signaling pathways that mediate survival and apoptosis.
Academic Article Analysis of c-Jun N-terminal kinase regulation and function.
Academic Article Functional cooperation of the proapoptotic Bcl2 family proteins Bmf and Bim in vivo.
Academic Article Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration.
Academic Article Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance.
Academic Article c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade.
Academic Article The p65/RelA subunit of NF-kappaB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor.
Academic Article JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.
Academic Article Suppression of Ras-stimulated transformation by the JNK signal transduction pathway.
Academic Article c-Jun NH(2)-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor.
Academic Article JunD mediates survival signaling by the JNK signal transduction pathway.
Academic Article Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia.
Academic Article The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase.
Academic Article Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways.
Academic Article Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling.
Academic Article Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain.
Academic Article JNK2 is a positive regulator of the cJun transcription factor.
Academic Article Oncogene addiction: role of signal attenuation.
Academic Article Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Academic Article Requirement of JIP scaffold proteins for NMDA-mediated signal transduction.
Academic Article c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway.
Academic Article Signal transduction cross talk mediated by Jun N-terminal kinase-interacting protein and insulin receptor substrate scaffold protein complexes.
Academic Article Microtubule stabilization by bone morphogenetic protein receptor-mediated scaffolding of c-Jun N-terminal kinase promotes dendrite formation.
Academic Article AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Academic Article Requirement of c-Jun NH(2)-terminal kinase for Ras-initiated tumor formation.
Academic Article JNK regulates FoxO-dependent autophagy in neurons.
Academic Article The role of JNK in the development of hepatocellular carcinoma.
Academic Article TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway.
Academic Article Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism.
Academic Article Cell biology. A scaffold switch to insulate.
Concept Vesicular Transport Proteins
Concept Membrane Proteins
Concept A Kinase Anchor Proteins
Concept DNA-Binding Proteins
Concept Heat-Shock Proteins
Concept Muscle Proteins
Concept Insulin Receptor Substrate Proteins
Concept High Mobility Group Proteins
Concept Hedgehog Proteins
Concept Mitochondrial Proteins
Concept Oncogene Proteins
Concept Carrier Proteins
Concept Proto-Oncogene Proteins c-bcl-2
Concept Cell Cycle Proteins
Concept Nuclear Proteins
Concept Recombinant Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept SMN Complex Proteins
Concept Repressor Proteins
Concept Bone Morphogenetic Proteins
Concept Myelin Proteins
Concept Proto-Oncogene Proteins c-akt
Concept Proteins
Concept Microtubule-Associated Proteins
Concept Proto-Oncogene Proteins c-vav
Concept Munc18 Proteins
Concept Suppressor of Cytokine Signaling Proteins
Concept Retinol-Binding Proteins, Plasma
Concept Cytoskeletal Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Proto-Oncogene Proteins c-myc
Concept ras Proteins
Concept Recombinant Fusion Proteins
Concept Saccharomyces cerevisiae Proteins
Concept Proto-Oncogene Proteins c-jun
Concept Caenorhabditis elegans Proteins
Concept Wnt Proteins
Concept Proto-Oncogene Proteins p21(ras)
Concept I-kappa B Proteins
Concept Apoptosis Regulatory Proteins
Concept Proto-Oncogene Proteins
Concept Armadillo Domain Proteins
Concept GTPase-Activating Proteins
Concept Nerve Tissue Proteins
Concept Tumor Suppressor Proteins
Concept RNA-Binding Proteins
Academic Article Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma.
Academic Article Pathological axonal death through a MAPK cascade that triggers a local energy deficit.
Academic Article Tead and AP1 Coordinate Transcription and Motility.
Academic Article TNF?-Mediated Cytotoxic Responses to IAP Inhibition Are Limited by the p38? MAPK Pathway.
Academic Article An alternative splicing program promotes adipose tissue thermogenesis.
Academic Article A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.
Academic Article JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins.
Academic Article Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.
Academic Article Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy.
Academic Article Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim.
Concept Dishevelled Proteins
Search Criteria
  • Proteins