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Search Results to Nils Henninger MD, PhD

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Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

Research Program

As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. The overarching goal of my research is to define mechanisms driving white matter damage and its contribution to functional outcome after brain injury.

My main basic science research is aimed at understanding the molecular mechanisms underlying axonal degeneration in the brain after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.

My main clinical research interest is focused on investigating chronic ischemic white matter injury in the brain termed leukoaraiosis and how it impacts outcome after ischemic stroke. Leukoaraiosis is common among patients with stroke as it shares common risk factors with stroke and has been linked to cognitive and neurological decline as well as increased stroke risk. Results from my research have highlighted that stroke patients with severe pre-existing leukoaraiosis have larger strokes, worse functional deficits at presentation, recovery to a lesser extent, and have an overall greater risk for functional dependence after their stroke as compared to patients with only mild leukoaraiosis.


--We accept residents and fellows year round to work on mentored clinical research projects.

--There are presently no vacancies in our lab.

One or more keywords matched the following items that are connected to Henninger, Nils

Item TypeName
Academic Article Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion.
Academic Article Leukoaraiosis and sex predict the hyperacute ischemic core volume.
Concept Leukoaraiosis
Academic Article Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion.
Academic Article Severe leukoaraiosis portends a poor outcome after traumatic brain injury.
Academic Article Leukoaraiosis predicts a poor 90-day outcome after endovascular stroke therapy.
Academic Article Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke.
Academic Article Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke".
Academic Article Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke.
Academic Article Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke.
Academic Article Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis.
Academic Article Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation.
Academic Article Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke.

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  • Leukoaraiosis