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Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

Research Program

As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. The overarching goal of my research is to define mechanisms driving white matter damage and its contribution to functional outcome after brain injury.

My main basic science research is aimed at understanding the molecular mechanisms underlying axonal degeneration in the brain after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.


--We accept residents and fellows year on a  case-by-case basis to work on mentored clinical research projects.

--There are presently no vacancies in our lab.

One or more keywords matched the following items that are connected to Henninger, Nils
Item TypeName
Academic Article Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study.
Academic Article Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging.
Academic Article Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment.
Academic Article Neuroprotective effect of hyperbaric oxygen therapy monitored by MR-imaging after embolic stroke in rats.
Academic Article Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials.
Academic Article Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke.
Academic Article Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke.
Academic Article Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat.
Academic Article Intravenous thrombolysis in a patient with known cavernous malformation: a first case report.
Academic Article MRI of stroke using hyperpolarized 129Xe.
Academic Article Acute ischemic stroke therapy.
Academic Article Preclinical acute ischemic stroke modeling.
Academic Article Statin use and microbleeds in patients with spontaneous intracerebral hemorrhage.
Academic Article Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI.
Academic Article A new model of thromboembolic stroke in the posterior circulation of the rat.
Academic Article Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging.
Academic Article Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats.
Academic Article Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging.
Academic Article Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke.
Academic Article Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model.
Academic Article G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke.
Academic Article Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy.
Academic Article Leukoaraiosis predicts poor 90-day outcome after acute large cerebral artery occlusion.
Academic Article Leukoaraiosis and sex predict the hyperacute ischemic core volume.
Academic Article QTc-prolongation in posterior circulation stroke.
Concept Stroke
Concept Stroke Volume
Academic Article Leukoaraiosis predicts cortical infarct volume after distal middle cerebral artery occlusion.
Academic Article Clot injection technique affects thrombolytic efficacy in a rat embolic stroke model: implications for translaboratory collaborations.
Academic Article Predictors of Outcome following Stroke due to Isolated M2 Occlusions.
Academic Article Leukoaraiosis predicts a poor 90-day outcome after endovascular stroke therapy.
Academic Article Pre and Post-stroke Use of Statins Improves Stroke Outcome.
Academic Article Prevalence of Pelvic Vein Pathology in Patients with Cryptogenic Stroke and Patent Foramen Ovale Undergoing MRV Pelvis.
Academic Article Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke.
Academic Article Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke.
Academic Article Response to Letter Regarding Article, "Leukoaraiosis Burden Significantly Modulates the Association Between Infarct Volume and National Institutes of Health Stroke Scale in Ischemic Stroke".
Academic Article Clinical impact of leukoaraiosis burden and chronological age on neurological deficit recovery and 90-day outcome after minor ischemic stroke.
Academic Article Impact of Leukoaraiosis Burden on Hemispheric Lateralization of the National Institutes of Health Stroke Scale Deficit in Acute Ischemic Stroke.
Academic Article ARTS (Aspiration-Retriever Technique for Stroke): Initial clinical experience.
Academic Article Extending the Time Window for Endovascular and Pharmacological Reperfusion.
Academic Article Atrial Fibrillation Is Associated With a Worse 90-Day Outcome Than Other Cardioembolic Stroke Subtypes.
Academic Article Phase III Preclinical Trials in Translational Stroke Research: Community Response on Framework and Guidelines.
Academic Article Newer Oral Anticoagulants: Stroke Prevention and Pitfalls.
Academic Article Time to Presentation Is Associated with Clinical Outcome in Hemispheric Stroke Patients Deemed Ineligible for Recanalization Therapy.
Academic Article White Matter Hyperintensity-Adjusted Critical Infarct Thresholds to Predict a Favorable 90-Day Outcome.
Academic Article Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort.
Academic Article Leukoaraiosis, intracerebral hemorrhage, and functional outcome after acute stroke thrombolysis.
Academic Article Stroke doctors: Who are we? A World Stroke Organization survey.
Academic Article Alberta Stroke Program Early CT Score Infarct Location Predicts Outcome Following M2 Occlusion.
Academic Article Emergency Department Length of Stay and Outcome after Ischemic Stroke.
Academic Article Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke.
Academic Article Leukoaraiosis Attenuates Diagnostic Accuracy of Large-Vessel Occlusion Scales.
Academic Article Left Ventricular Ejection Fraction and Clinically Defined Heart Failure to Predict 90-Day Functional Outcome After Ischemic Stroke.
Academic Article Pre-existing White Matter Hyperintensity Lesion Burden and Diagnostic Certainty of Transient Ischemic Attack.
Academic Article Nucleic Acid Therapies for Ischemic Stroke.
Academic Article Clinical and Radiological Characteristics of Vitamin K Versus Non-Vitamin K Antagonist Oral Anticoagulation-Related Intracerebral Hemorrhage.
Academic Article Leukoaraiosis Predicts Short-term Cognitive But not Motor Recovery in Ischemic Stroke Patients During Rehabilitation.
Academic Article Impact of Leukoaraiosis Severity on the Association of Time to Successful Reperfusion with 90-Day Functional Outcome After Large Vessel Occlusion Stroke.
Academic Article Infarct Evolution in a Large Animal Model of Middle Cerebral Artery Occlusion.
Academic Article Mechanical thrombectomy in acute stroke: Paying attention to white matter hyperintensities.
Academic Article Recrudescence of Old Stroke Deficits Among Transient Neurological Attacks.
Academic Article Association of Baseline Cardiac Troponin With Acute Myocardial Infarction in Stroke Patients Presenting Within 4.5 Hours.
Academic Article 12 versus 24?h bed rest after acute ischemic stroke thrombolysis: a preliminary experience.
Academic Article Prevalence of a Multiple Territory Stroke Pattern After Intravenous Thrombolysis.
Academic Article Early ischaemic and haemorrhagic complications after atrial fibrillation-related ischaemic stroke: analysis of the IAC study.
Academic Article Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation.
Academic Article Relationship of white matter lesion severity with early and late outcomes after mechanical thrombectomy for large vessel stroke.
Academic Article SARS-CoV-2 and Stroke in a New York Healthcare System.
Academic Article Mean platelet volume and its genetic variants relate to stroke severity and 1-year mortality.
Academic Article Anticoagulation Timing in Cardioembolic Stroke and Recurrent Event Risk.
Academic Article Anticoagulation Type and Early Recurrence in Cardioembolic Stroke: The IAC Study.
Academic Article Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System.
Academic Article Risk of Ischemic Stroke in Patients With Atrial Fibrillation After Extracranial Hemorrhage.
Academic Article Effects of Preexisting Psychotropic Medication Use on a Cohort of Patients with Ischemic Stroke Outcome.
Academic Article The Effect of Hyperglycemia on Infarct Growth after Reperfusion: An Analysis of the DEFUSE 3 trial.
Academic Article Ischaemic stroke on anticoagulation therapy and early recurrence in acute cardioembolic stroke: the IAC study.
Academic Article Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics.
Academic Article Carotid Stenosis and Recurrent Ischemic Stroke: A Post-Hoc Analysis of the POINT Trial.
Academic Article Effect of Alteplase Use on Outcomes in Patients With Atrial Fibrillation: Analysis of the Initiation of Anticoagulation After Cardioembolic Stroke Study.
Academic Article Antiplatelet Use and Ischemic Stroke Risk in Minor Stroke or Transient Ischemic Attack: A Post Hoc Analysis of the POINT Trial.
Concept Stroke Rehabilitation
Concept Stroke, Lacunar
Academic Article Infarct on Brain Imaging, Subsequent Ischemic Stroke, and Clopidogrel-Aspirin Efficacy: A Post Hoc Analysis of a Randomized Clinical Trial.
Academic Article Direct Oral Anticoagulants Versus Warfarin in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT): A Multicenter International Study.
Academic Article Novel Oxygen Carrier Slows Infarct Growth in Large Vessel Occlusion Dog Model Based on Magnetic Resonance Imaging Analysis.
Academic Article Association of Atrial Fibrillation Detected after Stroke with Cardiac Dysfunction and Features of Neurogenic Cardiac Injury.
Academic Article Association between the LACE+ index and unplanned 30-day hospital readmissions in hospitalized patients with stroke.
Academic Article Characteristics and outcomes of postpartum cerebral venous sinus thrombosis: A subgroup analysis of the ACTION-CVT study.
Academic Article Trends in Venous Thromboembolism Readmission Rates after Ischemic Stroke and Intracerebral Hemorrhage.
Academic Article Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial.
Academic Article Perioperative Acute Ischemic Stroke in Patients with Atrial Fibrillation.
Academic Article Stroke nurse navigator utilization reduces unplanned 30-day readmission in stroke patients treated with thrombolysis.
Award or Honor Receipt FWSO
Academic Article First pass effect as an independent predictor of functional outcomes in medium vessel occlusions: An analysis of an international multicenter study.
Academic Article Clinical outcome of patients with mild pre-stroke morbidity following endovascular treatment: a HERMES substudy.
Academic Article Penumbral imaging and functional outcome in patients with anterior circulation ischaemic stroke treated with endovascular thrombectomy versus medical therapy: a meta-analysis of individual patient-level data.
Academic Article eTICI reperfusion: defining success in endovascular stroke therapy.
Academic Article Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data.
Academic Article Endovascular therapy in acute ischemic stroke with poor reperfusion is associated with worse outcomes compared with best medical management: a HERMES substudy.
Academic Article Cost-Effectiveness of Endovascular Treatment in Large Vessel Occlusion Stroke With Mild Prestroke Disability: Results From the HERMES Collaboration.
Academic Article Comparison of Three Scores of Collateral Status for Their Association With Clinical Outcome: The HERMES Collaboration.
Academic Article Functional Outcomes of Patients =85 Years With Acute Ischemic Stroke Following EVT: A HERMES Substudy.
Academic Article Risk factors of unexplained early neurological deterioration after treatment for ischemic stroke due to large vessel occlusion: a post hoc analysis of the HERMES study.
Academic Article Value of infarct location in the prediction of functional outcome in patients with an anterior large vessel occlusion: results from the HERMES study.
Academic Article Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis.
Academic Article Effect of atrial fibrillation on endovascular thrombectomy for acute ischemic stroke. A meta-analysis of individual patient data from six randomised trials: Results from the HERMES collaboration.
Academic Article Effect of age and baseline ASPECTS on outcomes in large-vessel occlusion stroke: results from the HERMES collaboration.
Academic Article Stroke Laterality Did Not Modify Outcomes in the HERMES Meta-Analysis of Individual Patient Data of 7 Trials.
Academic Article Efficacy of endovascular thrombectomy in patients with M2 segment middle cerebral artery occlusions: meta-analysis of data from the HERMES Collaboration.
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  • Stroke