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One or more keywords matched the following properties of Henninger, Nils
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Biography

Dr. Henninger received his M.D. degree from the University of Mainz, Germany. Following residency training in Neurology at the University of Heidelberg, Germany and University of Massachusetts Medical School, Worcester, MA he completed a fellowship in Cerebrovascular Diseases at the Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA before joining the University of Massachusetts Medical School in 2012.

Research Program

As a cerebrovascular disease-trained neurologist I mostly see stroke patients in my clinic but I am broadly interested in emergency neurology. The overarching goal of my research is to define mechanisms driving white matter damage and its contribution to functional outcome after brain injury.

My main basic science research is aimed at understanding the molecular mechanisms underlying axonal degeneration in the brain after acute brain injury. My research has provided first evidence that by blocking a key gene driving Wallerian degeneration, Sarm1, it is possible to prevent axonal degeneration and preserve neurological function after brain trauma. These fundamental observations indicate that traumatic axonal degeneration is governed by a Wallerian degeneration-like mechanism and represent the first evidence that it is possible to prevent axonal degeneration after mammalian brain trauma in vivo. This is a major step forward in the field of traumatic brain injury, which represents a leading cause of adult disability and death in the US and for which there is no specific therapy available.

Positions

--We accept residents and fellows year on a  case-by-case basis to work on mentored clinical research projects.

--There are presently no vacancies in our lab.

Summary Dr. Henninger is a vascular neurologist with research interest in the neurobiology of axonal injury associated with traumatic brain injury and its contribution to functional outcome.
One or more keywords matched the following items that are connected to Henninger, Nils
Item TypeName
Academic Article Impaired spatial learning in a novel rat model of mild cerebral concussion injury.
Academic Article Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging.
Academic Article Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat.
Concept Trauma Severity Indices
Concept Diffuse Axonal Injury
Concept Injury Severity Score
Concept Brain Injuries
Concept Reperfusion Injury
Concept Head Injuries, Closed
Academic Article Severe leukoaraiosis portends a poor outcome after traumatic brain injury.
Academic Article Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.
Academic Article Extending the Time Window for Endovascular and Pharmacological Reperfusion.
Academic Article Lateral Ventricle Attenuates Underlying Traumatic Axonal Injury after Closed Head Injury in the Mouse.
Academic Article "Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients.
Academic Article Cortical Spreading Depression Denotes Concussion Injury.
Academic Article Which Spreading Depolarizations Are Deleterious To Brain Tissue?
Academic Article Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Academic Article Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury.
Concept Brain Injuries, Traumatic
Academic Article Association of Atrial Fibrillation Detected after Stroke with Cardiac Dysfunction and Features of Neurogenic Cardiac Injury.
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  • Wounds and Injuries