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King, Oliver
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Wellstone Program / Neurology

Academic Background

  • 2016-present: Assistant Professor, Neurology, UMMS / UMass Chan
  • 2013-2016: Assistant Professor, Cell and Developmental Biology, UMMS
  • 2007-2013: Scientist, Boston Biomedical Research Institute
  • 2004-2007: Postdoctoral Associate, Whitehead Institute
  • 2001-2004: Postdoctoral Fellow, Harvard Medical School
  • 2001: PhD in Mathematics, University of California, Berkeley
  • 1999: MS in Computer Science, University of California, Berkeley
  • 1992: BA in Mathematics, University of Hawaii, Manoa

 
Summary Dr. King is a computational biologist, with research interests in algorithm development and the analysis of high-throughput datasets. As part of a Wellstone Center focusing on facioscapulohumeral muscular dystrophy (FSHD) he studies transcriptional and epigenetic changes associated with disease, and genetic modifiers of disease severity.
One or more keywords matched the following items that are connected to King, Oliver
Item TypeName
Academic Article Binary templates for comma-free DNA codes
Academic Article Predicting phenotype from patterns of annotation.
Academic Article Characterizing gene sets with FuncAssociate.
Academic Article Intensity-based protein identification by machine learning from a library of tandem mass spectra.
Academic Article Predicting protein complex membership using probabilistic network reliability.
Academic Article Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo.
Academic Article Prion-like disorders: blurring the divide between transmissibility and infectivity.
Academic Article Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor.
Academic Article The Rat Grimace Scale: a partially automated method for quantifying pain in the laboratory rat via facial expressions.
Academic Article An open system for automatic home-cage behavioral analysis and its application to male and female mouse models of Huntington's disease.
Academic Article Using the Mouse Grimace Scale to reevaluate the efficacy of postoperative analgesics in laboratory mice.
Academic Article The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.
Academic Article Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis.
Academic Article Transcriptional profiling in facioscapulohumeral muscular dystrophy to identify candidate biomarkers.
Academic Article Linear constructions for DNA codes
Academic Article The mass of extremal doubly-even self-dual codes of length 40
Academic Article Stress granules as crucibles of ALS pathogenesis.
Academic Article Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy.
Academic Article GoFish finds genes with combinations of Gene Ontology attributes.
Academic Article Exome sequencing to identify de novo mutations in sporadic ALS trios.
Academic Article Predicting gene function from patterns of annotation.
Academic Article Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases.
Academic Article A non-parametric model for transcription factor binding sites.
Academic Article Predicting co-complexed protein pairs using genomic and proteomic data integration.
Academic Article Combining biological networks to predict genetic interactions.
Academic Article Comment on "Subgraphs in random networks".
Academic Article Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network.
Academic Article The loss of adaptive plasticity during long periods of environmental stasis.
Academic Article The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.
Academic Article The evolution of bet-hedging adaptations to rare scenarios.
Academic Article Combining guilt-by-association and guilt-by-profiling to predict Saccharomyces cerevisiae gene function.
Academic Article Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease.
Academic Article Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity.
Academic Article A systematic survey identifies prions and illuminates sequence features of prionogenic proteins.
Academic Article Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice.
Academic Article Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection.
Academic Article Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins.
Academic Article A yeast functional screen predicts new candidate ALS disease genes.
Academic Article Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.
Academic Article Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals.
Academic Article Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity.
Academic Article Daily scheduled high fat meals moderately entrain behavioral anticipatory activity, body temperature, and hypothalamic c-Fos activation.
Academic Article Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
Academic Article A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation.
Concept Tandem Mass Spectrometry
Concept Muscle, Smooth, Vascular
Concept Saliva
Concept Sequence Analysis, DNA
Concept Central Nervous System
Concept Survival Rate
Concept Genes, Regulator
Concept Mass Spectrometry
Concept Heat-Shock Proteins
Concept Genetic Association Studies
Concept Software
Concept Multigene Family
Concept Amyotrophic Lateral Sclerosis
Concept Sensitivity and Specificity
Concept Information Storage and Retrieval
Concept Heat-Shock Response
Concept Selection, Genetic
Concept Creutzfeldt-Jakob Syndrome
Concept Amino Acid Substitution
Concept Database Management Systems
Concept Ellis-Van Creveld Syndrome
Concept Freund's Adjuvant
Concept Amino Acid Sequence
Concept Two-Hybrid System Techniques
Concept Stress, Physiological
Concept Saccharomyces cerevisiae
Concept Cohort Studies
Concept Genome
Concept Statistics, Nonparametric
Concept Genes, Fungal
Concept Genome, Fungal
Concept Repetitive Sequences, Nucleic Acid
Concept Models, Statistical
Concept Species Specificity
Concept Signal Transduction
Concept Suprachiasmatic Nucleus
Concept Saccharomycetales
Concept Spinal Cord
Concept Hermanski-Pudlak Syndrome
Concept Protein Structure, Tertiary
Concept Myocytes, Smooth Muscle
Concept Genes, Insect
Concept Genes, Reporter
Concept Trinucleotide Repeat Expansion
Concept Muscle Fibers, Skeletal
Concept Sequence Alignment
Concept Binding Sites
Concept Saccharomyces cerevisiae Proteins
Concept Quantitative Trait Loci
Concept Induced Pluripotent Stem Cells
Concept DNA Breaks, Double-Stranded
Concept Cell Size
Concept Macromolecular Substances
Concept Stem Cell Transplantation
Concept Cross-Sectional Studies
Concept Oligonucleotide Array Sequence Analysis
Concept Sex Characteristics
Concept Sequence Analysis, Protein
Concept alpha-Synuclein
Concept Gene Silencing
Concept Base Sequence
Concept Alleles
Concept Systems Integration
Concept Muscle, Skeletal
Concept Genes, Homeobox
Concept Molecular Sequence Data
Academic Article Human skeletal muscle xenograft as a new preclinical model for muscle disorders.
Academic Article Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story?
Academic Article PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
Academic Article Identifying diagnostic DNA methylation profiles for facioscapulohumeral muscular dystrophy in blood and saliva using bisulfite sequencing.
Academic Article Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy.
Academic Article Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease.
Academic Article Morpholino-mediated Knockdown of DUX4 Toward Facioscapulohumeral Muscular Dystrophy Therapeutics.
Academic Article Using Katsurada's determination of the Eisenstein series to compute Siegel eigenforms
Academic Article Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains.
Academic Article A global analysis of IFT-A function reveals specialization for transport of membrane-associated proteins into cilia.
Academic Article Learning a semantic space from user's relevance feedback for image retrieval
Academic Article Precise therapeutic gene correction by a simple nuclease-induced double-stranded break.
Academic Article Ly6a Differential Expression in Blood-Brain Barrier Is Responsible for Strain Specific Central Nervous System Transduction Profile of AAV-PHP.B.
Academic Article Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy.
Academic Article Salivary metabolite levels in perinatally HIV-infected youth with periodontal disease.
Concept Heat Shock Transcription Factors
Concept Mice, 129 Strain
Concept Single-Cell Analysis
Concept High-Throughput Nucleotide Sequencing
Concept Transcriptome
Concept Exome
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept CRISPR-Cas Systems
Academic Article iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling.
Academic Article Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD.
Academic Article Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments.
Academic Article Multi-perspective retrieval, ranking and visualization of Web data
Academic Article Estimation of singular values of very large matrices using random sampling
Academic Article How does CONDENSATION behave with a finite number of samples?
Academic Article A Targeted Approach for Evaluating DUX4-Regulated Proteins as Potential Serum Biomarkers for Facioscapulohumeral Muscular Dystrophy Using Immunoassay Proteomics.
Academic Article A self-complementary AAV proviral plasmid that reduces cross-packaging and ITR promoter activity in AAV vector preparations.
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