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Khvorova, Anastasia

One or more keywords matched the following items that are connected to Khvorova, Anastasia

Item Type	Name
Academic Article	A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.
Academic Article	Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomes.
Concept	Nucleic Acids
Concept	Peptide Nucleic Acids
Academic Article	Guanabenz (Wytensin?) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.
Academic Article	Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.
Academic Article	Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.
Academic Article	Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
Academic Article	5?-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Academic Article	Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Academic Article	Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs.
Academic Article	Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics.
Academic Article	Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Academic Article	Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Academic Article	Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Academic Article	Nucleic Acid Therapeutics for Neurological Diseases.
Academic Article	Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In?Vivo.
Academic Article	2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
Academic Article	Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference.
Academic Article	The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Academic Article	Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
Academic Article	Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Academic Article	PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Academic Article	Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
Academic Article	Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Academic Article	Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy.
Academic Article	Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Academic Article	Dendritic amphiphilic siRNA: Selective albumin binding, in?vivo efficacy, and low toxicity.
Academic Article	Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
Academic Article	Multispecies-targeting siRNAs for the modulation of JAK1 in the skin.
Academic Article	A combinatorial approach for achieving CNS-selective RNAi.
Academic Article	Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
Academic Article	Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA.
Academic Article	A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
Academic Article	mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs).
Academic Article	Identification of selective and non-selective C9ORF72 targeting in?vivo active siRNAs.

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Nucleic Acids