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Khvorova, Anastasia
One or more keywords matched the following items that are connected to
Khvorova, Anastasia
Item Type
Name
Academic Article
A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens.
Academic Article
Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomes.
Concept
Nucleic Acids
Concept
Peptide Nucleic Acids
Academic Article
Guanabenz (Wytensin?) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.
Academic Article
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.
Academic Article
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.
Academic Article
Visualization of self-delivering hydrophobically modified siRNA cellular internalization.
Academic Article
5?-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Academic Article
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Academic Article
Functional features defining the efficacy of cholesterol-conjugated, self-deliverable, chemically modified siRNAs.
Academic Article
Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics.
Academic Article
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Academic Article
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Academic Article
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.
Academic Article
Nucleic Acid Therapeutics for Neurological Diseases.
Academic Article
Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In?Vivo.
Academic Article
2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
Academic Article
Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference.
Academic Article
The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Academic Article
Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
Academic Article
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
Academic Article
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Academic Article
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
Academic Article
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Academic Article
Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy.
Academic Article
Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo.
Academic Article
Dendritic amphiphilic siRNA: Selective albumin binding, in?vivo efficacy, and low toxicity.
Academic Article
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors.
Academic Article
Multispecies-targeting siRNAs for the modulation of JAK1 in the skin.
Academic Article
A combinatorial approach for achieving CNS-selective RNAi.
Academic Article
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
Academic Article
Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA.
Academic Article
A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.
Academic Article
mRNA-specific readthrough of nonsense codons by antisense oligonucleotides (R-ASOs).
Academic Article
Identification of selective and non-selective C9ORF72 targeting in?vivo active siRNAs.
Academic Article
Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation.
Search Criteria
Nucleic Acids