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One or more keywords matched the following items that are connected to Heneka, Michael
Item TypeName
Academic Article Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis.
Academic Article Noradrenergic regulation of inflammatory gene expression in brain.
Academic Article Intrinsic regulation of brain inflammatory responses.
Academic Article Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists.
Academic Article The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.
Academic Article Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
Academic Article The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice.
Academic Article PPARgamma as a therapeutic target in central nervous system diseases.
Academic Article Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.
Academic Article Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
Academic Article Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
Academic Article Inflammatory processes in Alzheimer's disease.
Academic Article Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model.
Academic Article Switching on the lights for gene therapy.
Academic Article PPARs in the brain.
Academic Article The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications.
Academic Article Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism.
Academic Article Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Academic Article NOS2 gene deficiency protects from sepsis-induced long-term cognitive deficits.
Academic Article Neuroglia in neurodegeneration.
Academic Article Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.
Academic Article Neuroinflammatory processes in Alzheimer's disease.
Academic Article Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
Academic Article Restraint stress increases neuroinflammation independently of amyloid ? levels in amyloid precursor protein/PS1 transgenic mice.
Academic Article Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study.
Academic Article Nitration of tyrosine 10 critically enhances amyloid ? aggregation and plaque formation.
Academic Article Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12.
Academic Article TLR2 is a primary receptor for Alzheimer's amyloid ? peptide to trigger neuroinflammatory activation.
Academic Article Nitric oxide decreases the enzymatic activity of insulin degrading enzyme in APP/PS1 mice.
Academic Article Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.
Academic Article Norepinephrine increases I kappa B alpha expression in astrocytes.
Academic Article Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
Academic Article Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis.
Academic Article Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells.
Academic Article PPAR?/RXRa-induced and CD36-mediated microglial amyloid-? phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
Academic Article NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Academic Article Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.
Academic Article Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons.
Academic Article Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.
Academic Article Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA.
Academic Article Protection by pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation.
Academic Article Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
Academic Article Systemic inflammation induces apoptosis with variable vulnerability of different brain regions.
Academic Article Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
Academic Article Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
Academic Article Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms.
Academic Article Disease-modifying therapies in Alzheimer's disease: how far have we come?
Academic Article Imaging-guided gene therapy of experimental gliomas.
Academic Article Multitracer positron emission tomographic imaging of exogenous gene expression mediated by a universal herpes simplex virus 1 amplicon vector.
Academic Article Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders.
Academic Article PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease.
Academic Article Noradrenergic denervation facilitates the release of acetylcholine and serotonin in the hippocampus: towards a mechanism underlying upregulations described in MCI patients.
Academic Article PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
Academic Article alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Academic Article Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia.
Academic Article Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
Academic Article Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.
Academic Article Distinct modulation of microglial amyloid ? phagocytosis and migration by neuropeptides (i).
Academic Article Locus coeruleus degeneration exacerbates olfactory deficits in APP/PS1 transgenic mice.
Academic Article Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.
Academic Article Extracellular phosphorylation of the amyloid ?-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
Academic Article Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial A? phagocytosis.
Academic Article Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.
Academic Article Glial cells in (patho)physiology.
Academic Article Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease.
Academic Article A randomized, double blind, placebo-controlled trial of pioglitazone in combination with riluzole in amyotrophic lateral sclerosis.
Academic Article Mrp14 deficiency ameliorates amyloid ? burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing.
Academic Article CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia.
Academic Article Studying M1 and M2 states in adult microglia.
Concept Disease Models, Animal
Concept Animals, Newborn
Concept Animals
Concept Behavior, Animal
Concept Models, Animal
Concept Housing, Animal
Academic Article Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.
Academic Article CXCR3 modulates glial accumulation and activation in cuprizone-induced demyelination of the central nervous system.
Academic Article Macrophages derived from infiltrating monocytes mediate autoimmune myelin destruction.
Academic Article Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
Academic Article Body fluid cytokine levels in mild cognitive impairment and Alzheimer's disease: a comparative overview.
Academic Article CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer's disease model.
Academic Article Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits.
Academic Article Innate immunity in Alzheimer's disease.
Academic Article Neuroinflammation in Alzheimer's disease.
Academic Article Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease.
Academic Article ?-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Academic Article Microglia in Alzheimer's disease: the good, the bad and the ugly.
Academic Article Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming.
Academic Article Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease.
Academic Article Inflammasome activation and innate immunity in Alzheimer's disease.
Academic Article Danger-associated molecular patterns in Alzheimer's disease.
Academic Article IL-17A Promotes Granulocyte Infiltration, Myelin Loss, Microglia Activation, and Behavioral Deficits During Cuprizone-Induced Demyelination.
Academic Article Personalized genetics of the cholinergic blockade of neuroinflammation.
Academic Article Intramembranous processing by ?-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
Academic Article Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
Academic Article Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Academic Article United Again: STING and the Police.
Academic Article Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
Academic Article Inflammasome signalling in brain function and neurodegenerative disease.
Academic Article Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis.
Academic Article Proteome profiling of s-nitrosylated synaptosomal proteins by isobaric mass tags.
Academic Article Targeting Neuroinflammation to Treat Alzheimer's Disease.
Academic Article Neuroinflammatory responses in Alzheimer's disease.
Academic Article Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration.
Academic Article Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-? plaques: A potential role in shaping plaque pathology?
Academic Article Variability and temporal dynamics of novel object recognition in aging male C57BL/6 mice.
Academic Article The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (A?) species on long-term potentiation (LTP).
Academic Article Microglia in Alzheimer's disease.
Academic Article Microglia take centre stage in neurodegenerative disease.
Academic Article CNS-Specific Synthesis of Interleukin 23 Induces a Progressive Cerebellar Ataxia and the Accumulation of Both T and B Cells in the Brain: Characterization of a Novel Transgenic Mouse Model.
Academic Article Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.
Academic Article Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome.
Academic Article Microglia in Neurodegenerative Disorders.
Academic Article In Vivo Phagocytosis Analysis of Amyloid Beta.
Academic Article A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.
Academic Article Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Academic Article The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease.
Academic Article Norepinephrine as a modulator of microglial dynamics.
Academic Article Inflammasome-mediated innate immunity in Alzheimer's disease.
Academic Article NLRP3 inflammasome activation drives tau pathology.
Academic Article Vaccination with (1-11)E2 in alum efficiently induces an antibody response to ?-amyloid without affecting brain ?-amyloid load and microglia activation in 3xTg mice.
Academic Article Soluble A? oligomers and protofibrils induce NLRP3 inflammasome activation in microglia.
Academic Article ?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
Academic Article Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease.
Academic Article Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent.
Academic Article Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.
Academic Article mTOR-dependent translation amplifies microglia priming in aging mice.
Academic Article Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice.
Academic Article Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model.
Academic Article In vivo mechanisms of cortical network dysfunction induced by systemic inflammation.
Academic Article Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing.
Academic Article Differential interaction with TREM2 modulates microglial uptake of modified A? species.
Academic Article Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies.
Academic Article Peripheral and central immune system crosstalk in Alzheimer disease - a research prospectus.
Academic Article Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Academic Article Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
Academic Article SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation.
Academic Article TREM2 modulates differential deposition of modified and non-modified A? species in extracellular plaques and intraneuronal deposits.
Academic Article Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
Academic Article Inflammasome activation in neurodegenerative diseases.
Academic Article Reactive microglia are the major source of tumor necrosis factor alpha and contribute to astrocyte dysfunction and acute seizures in experimental temporal lobe epilepsy.
Academic Article ApoE4 makes microglia trem2bling.
Academic Article ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain.
Academic Article Characterizing microglial senescence: Tau as a key player.
Academic Article Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Academic Article Immune Activation in Alzheimer Disease.
Academic Article The endotoxin hypothesis of Alzheimer's disease.
Academic Article TREM1 is the new kid on the block for the aging-associated innate immune response and Alzheimer's disease.
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