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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes.
sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.
Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.
Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-? plaques: A potential role in shaping plaque pathology?
A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.
Differential interaction with TREM2 modulates microglial uptake of modified A? species.
TREM2 modulates differential deposition of modified and non-modified A? species in extracellular plaques and intraneuronal deposits.
ApoE4 makes microglia trem2bling.