| Item Type | Name |
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Academic Article
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Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis.
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Academic Article
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Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide.
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Academic Article
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Noradrenaline deficiency in brain increases beta-amyloid plaque burden in an animal model of Alzheimer's disease.
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Academic Article
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Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways.
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Academic Article
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Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
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Academic Article
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Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
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Academic Article
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Neuroinflammatory processes in Alzheimer's disease.
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Academic Article
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Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
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Academic Article
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Restraint stress increases neuroinflammation independently of amyloid ? levels in amyloid precursor protein/PS1 transgenic mice.
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Academic Article
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Nitration of tyrosine 10 critically enhances amyloid ? aggregation and plaque formation.
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Academic Article
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Opposing roles for CXCR3 signaling in central nervous system versus ocular inflammation mediated by the astrocyte-targeted production of IL-12.
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Academic Article
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Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.
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Academic Article
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Norepinephrine increases I kappa B alpha expression in astrocytes.
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Academic Article
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Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma.
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Academic Article
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Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells.
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Academic Article
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PPAR?/RXRa-induced and CD36-mediated microglial amyloid-? phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.
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Academic Article
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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
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Academic Article
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Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.
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Academic Article
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Interleukin-1 beta and lipopolysaccharide decrease soluble guanylyl cyclase in brain cells: NO-independent destabilization of protein and NO-dependent decrease of mRNA.
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Academic Article
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Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
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Academic Article
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Systemic inflammation induces apoptosis with variable vulnerability of different brain regions.
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Academic Article
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Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients.
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Academic Article
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Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma.
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Academic Article
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Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice.
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Academic Article
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Disease-modifying therapies in Alzheimer's disease: how far have we come?
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Academic Article
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GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
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Academic Article
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PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
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Academic Article
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alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
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Academic Article
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Induced LC degeneration in APP/PS1 transgenic mice accelerates early cerebral amyloidosis and cognitive deficits.
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Academic Article
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Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.
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Academic Article
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Neuroinflammatory and behavioural changes in the Atp7B mutant mouse model of Wilson's disease.
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Academic Article
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Extracellular phosphorylation of the amyloid ?-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
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Academic Article
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Critical role of astroglial apolipoprotein E and liver X receptor-a expression for microglial A? phagocytosis.
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Academic Article
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Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.
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Academic Article
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Imaging microglial activation and glucose consumption in a mouse model of Alzheimer's disease.
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Academic Article
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A pan-European study of the C9orf72 repeat associated with FTLD: geographic prevalence, genomic instability, and intermediate repeats.
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Academic Article
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Mrp14 deficiency ameliorates amyloid ? burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing.
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Academic Article
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CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia.
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Concept
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Protein-Tyrosine Kinases
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Concept
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Protein Binding
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Concept
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Protein Subunits
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Concept
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Protein Transport
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Concept
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Amyloid beta-Protein Precursor
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Concept
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Protein Folding
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Concept
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Protein Processing, Post-Translational
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Glial Fibrillary Acidic Protein
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Concept
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Protein Biosynthesis
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Concept
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Cyclic AMP-Dependent Protein Kinases
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Concept
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bcl-2-Associated X Protein
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Concept
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C-Reactive Protein
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Concept
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Protein Interaction Domains and Motifs
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Concept
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Protein Denaturation
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Concept
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Protein Synthesis Inhibitors
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Concept
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bcl-Associated Death Protein
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Concept
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GAP-43 Protein
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Concept
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Amyloid Precursor Protein Secretases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Concept
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Protein Isoforms
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Concept
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Protein Array Analysis
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Academic Article
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Innate immune activation in neurodegenerative disease.
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Academic Article
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Ear2 deletion causes early memory and learning deficits in APP/PS1 mice.
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Academic Article
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Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.
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Academic Article
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Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits.
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Academic Article
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Neuroinflammation in Alzheimer's disease.
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Academic Article
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?-Secretase processing of APP inhibits neuronal activity in the hippocampus.
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Academic Article
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Early Changes in Hippocampal Neurogenesis in Transgenic Mouse Models for Alzheimer's Disease.
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Academic Article
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TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
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Academic Article
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Inflammasome activation and innate immunity in Alzheimer's disease.
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Academic Article
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Intramembranous processing by ?-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
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Academic Article
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Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
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Academic Article
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Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
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Academic Article
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Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
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Academic Article
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Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.
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Academic Article
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Characterization and clinical use of inflammatory cerebrospinal fluid protein markers in Alzheimer's disease.
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Academic Article
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Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-? plaques: A potential role in shaping plaque pathology?
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Academic Article
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A novel CHCHD10 mutation implicates a Mia40-dependent mitochondrial import deficit in ALS.
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Academic Article
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Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression.
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Academic Article
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Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer's disease pathogenesis.
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Academic Article
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Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome.
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Academic Article
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A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.
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Academic Article
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NLRP3 inflammasome activation drives tau pathology.
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Academic Article
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Soluble A? oligomers and protofibrils induce NLRP3 inflammasome activation in microglia.
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Academic Article
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?-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia.
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Academic Article
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Enduring Changes in Neuronal Function upon Systemic Inflammation Are NLRP3 Inflammasome Dependent.
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Academic Article
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Interrelations of Alzheimer?s disease candidate biomarkers neurogranin, fatty acid-binding protein 3 and ferritin to neurodegeneration and neuroinflammation.
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Academic Article
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mTOR-dependent translation amplifies microglia priming in aging mice.
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Academic Article
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Deletion of the inflammatory S100-A9/MRP14 protein does not influence survival in hSOD1G93A ALS mice.
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Academic Article
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Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
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Academic Article
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Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.
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Academic Article
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Differential interaction with TREM2 modulates microglial uptake of modified A? species.
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Academic Article
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Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct a-Synuclein Assemblies.
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Academic Article
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Proteopathic tau primes and activates interleukin-1? via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
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Academic Article
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Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes.
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Academic Article
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Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer's disease pathology.
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Academic Article
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Inflammasome activation in neurodegenerative diseases.
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Concept
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NLR Family, Pyrin Domain-Containing 3 Protein
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Concept
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Chitinase-3-Like Protein 1
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Concept
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Sequestosome-1 Protein
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Concept
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ADAM10 Protein
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Concept
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Protein Domains
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Concept
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Concept
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C9orf72 Protein
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Concept
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Fatty Acid Binding Protein 3
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Concept
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Protein Interaction Maps
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Concept
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Protein Aggregation, Pathological
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Concept
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Protein Aggregates
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Academic Article
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Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer's disease: results from the DELCODE study.
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Academic Article
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NLRP3-directed antisense oligonucleotides reduce microglial immunoactivities in vitro.
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Academic Article
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Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS.
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Academic Article
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Biflavonoid Methylchamaejasmin and Khaya grandifoliola?Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation.
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Academic Article
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Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes.
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Academic Article
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Association of Neurogranin and BACE1 With Clinical Cognitive Decline in Individuals With Subjective Cognitive Decline.
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Academic Article
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The putative contribution of cellular senescence to driving tauopathies.
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Academic Article
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Identification of isoAsp7-A? as a major A? variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia.
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Academic Article
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NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer's disease progression.
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Academic Article
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The Role of Neuroinflammation in Alzheimer's Disease: A Systematic Literature Review (P7-9.013).
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