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One or more keywords matched the following properties of Behar, Samuel
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Immunity to Tuberculosis. It is estimated that 1/3 of the world’s population has been infected with Mycobacterium tuberculosis (Mtb). In the majority of infected people, the immune response is able to adequately control the infection, and consequently only 5-10% will develop clinical disease during their lifetime. My long-term goal is to understand the immunological basis for protective immunity. One way we are investigating this problem is to determine why different mouse strains differ in their susceptibility to tuberculosis. We have observed that certain susceptible mouse strains are unable to efficiently recruit T cells to the lung following infection with Mtb, and this failure likely contributes to increased mortality and morbidity of susceptible mice. Therefore, we are particularly interested in the early events leading to the initiation of the pulmonary immune response following respiratory Mtb infection. This includes establishing how T cells and myeloid cells are recruited back to the lung and how these cells mediate their effector functions.

Although BCG is used universally as a vaccine, its efficacy in preventing pulmonary tuberculosis is controversial. Most Mtb infected individuals develop long-lived immunity that contains the infection in a T cell-dependent manner. Thus, there is considerable interest in how different T cell subsets contribute to immunity and whether vaccination can stimulate protective T cells. Delineating the role of CD8+ T cells in host immunity to Mtb has been hindered by the paucity of antigens known to be recognized by CD8+ T cells. Our antigen discovery program has successfully identified and defined several mycobacterial peptide epitopes that are recognized by CD8+ T cells. For example, CD8+ T cells specific for culture filtrate protein-10 (CFP10) are found in infected people, indicating that CFP10 can prime CD8+ T cells after infection. Notably, CFP10 is encoded in the RD1 genetic locus, which is associated with Mtb virulence. The aim of our studies is to identify, enumerate and functionally characterize antigen-specific CD8+ T cells that are elicited following pulmonary infection. Finally, we are determining whether these antigens can be used as vaccines to elicit protective immunity.

Summary Focus: We seek to understand how the causative agent of tuberculosis, namely the bacterium Mycobacterium tuberculosis evades host immunity, and how different components of the immune response work together to contain infection. Our ultimate goal is to inform vaccine development and the design of host directed therapy.
One or more keywords matched the following items that are connected to Behar, Samuel
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Academic Article Cytolytic CD8+ T cells recognizing CFP10 are recruited to the lung after Mycobacterium tuberculosis infection.
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Academic Article Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice.
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Academic Article Anamnestic responses of mice following Mycobacterium tuberculosis infection.
Academic Article Antigen-specific CD8+ T cells and the development of central memory during Mycobacterium tuberculosis infection.
Academic Article Vaccine-elicited 10-kilodalton culture filtrate protein-specific CD8+ T cells are sufficient to mediate protection against Mycobacterium tuberculosis infection.
Academic Article Mycolyltransferase-mediated glycolipid exchange in Mycobacteria.
Academic Article Discordant QuantiFERON-TB Gold test results among US healthcare workers with increased risk of latent tuberculosis infection: a problem or solution?
Academic Article Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death.
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Academic Article Innate invariant NKT cells recognize Mycobacterium tuberculosis-infected macrophages, produce interferon-gamma, and kill intracellular bacteria.
Academic Article Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair.
Academic Article Alpha-galactosylceramide as a therapeutic agent for pulmonary Mycobacterium tuberculosis infection.
Academic Article Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis.
Academic Article Tim3 binding to galectin-9 stimulates antimicrobial immunity.
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Academic Article Requirement for invariant chain in macrophages for Mycobacterium tuberculosis replication and CD1d antigen presentation.
Academic Article Regulation of neutrophils by interferon-? limits lung inflammation during tuberculosis infection.
Academic Article A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis.
Academic Article Efferocytosis is an innate antibacterial mechanism.
Academic Article T cells home to the thymus and control infection.
Academic Article Antigen-specific CD8(+) T cells and protective immunity to tuberculosis.
Academic Article IL-1? promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
Concept Mycobacterium Infections
Concept Mycobacterium tuberculosis
Concept Mycobacterium avium
Concept Mycobacterium
Concept Mycobacterium leprae
Concept Mycobacterium smegmatis
Concept Mycobacterium bovis
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Academic Article Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.
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Academic Article Mycobacterium tuberculosis-specific CD4+ and CD8+ T cells differ in their capacity to recognize infected macrophages.
Academic Article Vaccine-elicited memory CD4+ T cell expansion is impaired in the lungs during tuberculosis.
Academic Article Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during Mycobacterium tuberculosis Infection.
Academic Article TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.
Academic Article Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice.
Academic Article Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.
Academic Article CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis.
Academic Article A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response.
Academic Article Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.
Academic Article CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.
Academic Article IFN? and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy.
Academic Article Multiplexed Strain Phenotyping Defines Consequences of Genetic Diversity in Mycobacterium tuberculosis for Infection and Vaccination Outcomes.
Academic Article Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.
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