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Dr. Leslie Berg

T lymphocyte development and activation

The research in my laboratory is aimed at understanding the signal transduction pathways importantforTlymphocyte development and activation. For these studies, we use a combination of mouse genetics (transgenics and knockouts), biochemistry, and cellular immunology. Our current work focuses on three projects. First, we have identified a tyrosine kinase, Jak3, involved in cytokine receptor signaling, and have generated Jak3-deficient mice. These mice have severe defects in lymphocyte development and function. Second, we have identified a novel tyrosine kinase, Itk, involved in T cell receptor signaling. Using Itk-deficient mice generated in the lab we are currently examining the role of this protein in lymphocyte development and activation.

One or more keywords matched the following items that are connected to Berg, Leslie

Item TypeName
Academic Article New insights into the regulation and functions of Tec family tyrosine kinases in the immune system.
Academic Article Compartmentalized Eph receptor and ephrin expression in the thymus.
Academic Article Signaling through Itk promotes T helper 2 differentiation via negative regulation of T-bet.
Academic Article Tec family kinases in T lymphocyte development and function.
Academic Article Itk is not essential for CD28 signaling in naive T cells.
Academic Article The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells.
Academic Article The "bubble boy" paradox: an answer that led to a question.
Academic Article c-Abl, an additional tyrosine kinase required for T cell development and function.
Academic Article The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.
Academic Article Cell cycle progression following naive T cell activation is independent of Jak3/common gamma-chain cytokine signals.
Academic Article Strength of T cell receptor signaling strikes again.
Academic Article Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase.
Academic Article The absence of Itk inhibits positive selection without changing lineage commitment.
Academic Article The role of Tec family kinases in T cell development and function.
Academic Article A network of high-mobility group box transcription factors programs innate interleukin-17 production.
Academic Article Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.
Academic Article Itk phosphorylation sites are required for functional activity in primary T cells.
Academic Article Signals that regulate lymphocyte development and differentiation.
Academic Article Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help.
Academic Article Cutting edge: an alternative pathway of CD4+ T cell differentiation is induced following activation in the absence of gamma-chain-dependent cytokine signals.
Academic Article Itk and Th2 responses: action but no reaction.
Academic Article Tec kinases in T cell and mast cell signaling.
Academic Article Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.
Academic Article Subtle defects in pre-TCR signaling in the absence of the Tec kinase Itk.
Academic Article The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival.
Academic Article Janus-kinase-3-dependent signals induce chromatin remodeling at the Ifng locus during T helper 1 cell differentiation.
Academic Article Tec kinase Itk in gammadeltaT cells is pivotal for controlling IgE production in vivo.
Academic Article Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.
Academic Article Disrupting the intermolecular self-association of Itk enhances T cell signaling.
Academic Article T-cell signaling regulated by the Tec family kinase, Itk.
Academic Article IFN-alpha beta and self-MHC divert CD8 T cells into a distinct differentiation pathway characterized by rapid acquisition of effector functions.
Academic Article Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
Academic Article Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes.
Academic Article TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
Academic Article Signaling pathways that regulate T cell development and differentiation.
Academic Article The Tec kinase ITK regulates thymic expansion, emigration, and maturation of ?d NKT cells.
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Cell Lineage
Concept Receptors, Antigen, T-Cell
Concept Cell Survival
Concept NIH 3T3 Cells
Concept Jurkat Cells
Concept Dendritic Cells
Concept Genes, T-Cell Receptor
Concept CHO Cells
Concept Cell Differentiation
Concept Bone Marrow Cells
Concept Cell Polarity
Concept Cell Movement
Concept Cells, Cultured
Concept Cell Separation
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Natural Killer T-Cells
Concept Cell Proliferation
Concept Cell Cycle
Concept Cell Aging
Concept Cell Migration Inhibition
Concept Th1 Cells
Concept Antigen-Presenting Cells
Concept Th2 Cells
Concept Cell Line
Concept Mast Cells
Concept Receptors, Antigen, B-Cell
Concept Killer Cells, Natural
Concept Cell Line, Tumor
Academic Article Epigenetic modifications induced by Blimp-1 Regulate CD8? T cell memory progression during acute virus infection.
Academic Article CD28 and ITK signals regulate autoreactive T cell trafficking.
Academic Article Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection.
Academic Article Innate PLZF+CD4+ aß T cells develop and expand in the absence of Itk.
Academic Article Development of innate CD4+ and CD8+ T cells in Itk-deficient mice is regulated by distinct pathways.
Academic Article Regulation of tissue-dependent differences in CD8+ T cell apoptosis during viral infection.
Academic Article Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Academic Article Suppression of systemic autoimmunity by the innate immune adaptor STING.
Academic Article TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection.
Academic Article A Small Molecule Inhibitor of ITK and RLK Impairs Th1 Differentiation and Prevents Colitis Disease Progression.
Academic Article IRF4 Regulates the Ratio of T-Bet to Eomesodermin in CD8+ T Cells Responding to Persistent LCMV Infection.
Academic Article T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells.
Academic Article Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity.
Academic Article NKG2C/E Marks the Unique Cytotoxic CD4 T Cell Subset, ThCTL, Generated by Influenza Infection.
Academic Article High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells.
Academic Article Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory.
Academic Article Peptide Antigen Concentration Modulates Digital NFAT1 Activation in Primary Mouse Naive CD8+ T Cells as Measured by Flow Cytometry of Isolated Cell Nuclei.
Academic Article The Transcription Factor Runx2 Is Required for Long-Term Persistence of Antiviral CD8+ Memory T Cells.
Academic Article Multidomain Control Over TEC Kinase Activation State Tunes the T Cell Response.
Academic Article CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.

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