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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.