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Academic Article
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Engagement of the Lewis X antigen (CD15) results in monocyte activation.
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Academic Article
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Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
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Academic Article
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Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
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Academic Article
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Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers.
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Academic Article
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Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
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Academic Article
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Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
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Academic Article
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Characterization of proinflammatory cytokine production and CD14 expression by murine alveolar macrophage cell lines.
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Academic Article
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Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent.
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Academic Article
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Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
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Academic Article
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Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
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Academic Article
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Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
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Academic Article
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Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists.
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Academic Article
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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
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Academic Article
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Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice.
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Academic Article
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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
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Academic Article
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
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Academic Article
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Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi.
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Academic Article
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Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
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Academic Article
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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
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Academic Article
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MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
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Academic Article
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Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent.
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Academic Article
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Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
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Academic Article
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Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.
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Academic Article
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MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
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Academic Article
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c-Jun kinase is a critical signaling molecule in a neonatal model of group B streptococcal sepsis.
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Academic Article
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The biology of Toll-like receptors.
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Academic Article
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A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
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Academic Article
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Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
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Academic Article
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Toll-like receptor-dependent discrimination of streptococci.
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Academic Article
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A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.
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Academic Article
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Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
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Academic Article
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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
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Academic Article
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YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
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Academic Article
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Activation of TLR2 and TLR4 by glycosylphosphatidylinositols derived from Toxoplasma gondii.
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Academic Article
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
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Academic Article
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Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor.
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Academic Article
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Comparative study of lipopolysaccharide-, lipid IVa-, and lipid X-induced tumor necrosis factor production in murine macrophage-like cell lines.
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Academic Article
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Lipopolysaccharide, but not lethal infection, releases tumor necrosis factor in mice.
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Academic Article
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TIRAP: how Toll receptors fraternize.
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Academic Article
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TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article
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Malaria primes the innate immune response due to interferon-gamma induced enhancement of toll-like receptor expression and function.
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Academic Article
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Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
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Academic Article
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Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
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Academic Article
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
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Academic Article
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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
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Academic Article
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Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
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Academic Article
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Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
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Academic Article
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Activation of the NLRP3 inflammasome by group B streptococci.
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Academic Article
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Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
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Academic Article
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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article
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Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
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Academic Article
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Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
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Academic Article
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Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
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Academic Article
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The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
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Academic Article
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Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
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Academic Article
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Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
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Academic Article
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Acyclic analogue of lipid A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway.
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Academic Article
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The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated.
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Academic Article
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Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide.
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Academic Article
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Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans.
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Academic Article
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Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
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Academic Article
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Innate immune responses to Rhodococcus equi.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.
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Academic Article
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Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
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Academic Article
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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
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Academic Article
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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
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Academic Article
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Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
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Academic Article
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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Academic Article
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MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
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Academic Article
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Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
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Academic Article
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MUC1 mucin is a negative regulator of toll-like receptor signaling.
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Academic Article
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Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
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Academic Article
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TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
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Academic Article
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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
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Academic Article
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TLR3-mediated IFN-? gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
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Academic Article
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Macrophages recognize streptococci through bacterial single-stranded RNA.
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Academic Article
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MyD88-dependent pathway is essential for the innate immunity to Enterocytozoon bieneusi.
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Academic Article
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Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis.
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Academic Article
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Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
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Academic Article
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
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Academic Article
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NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA.
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Academic Article
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Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
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Academic Article
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The history of Toll-like receptors - redefining innate immunity.
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Academic Article
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SDZ MRL 953, a lipid A analog as selective cytokine inducer.
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Concept
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TNF Receptor-Associated Factor 6
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Concept
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TNF Receptor-Associated Factor 3
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Concept
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Myeloid Differentiation Factor 88
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Concept
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Interferon Regulatory Factor-7
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Concept
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STAT3 Transcription Factor
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Concept
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Complement Factor H
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Concept
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Tumor Necrosis Factor-alpha
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Concept
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Granulocyte-Macrophage Colony-Stimulating Factor
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Concept
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Interferon Regulatory Factor-3
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Concept
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Transcription Factor AP-1
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Concept
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Receptors, Tumor Necrosis Factor, Type I
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Concept
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Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
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Concept
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Growth Differentiation Factor 5
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Concept
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Receptors, Tumor Necrosis Factor
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Concept
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Platelet Activating Factor
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Concept
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Transcription Factor RelA
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Academic Article
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
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Academic Article
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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
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Academic Article
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Daily Rhythms of TNFa Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
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Academic Article
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The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.
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Academic Article
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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
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Academic Article
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Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
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Academic Article
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Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum.
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Academic Article
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The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.
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