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Golenbock, Douglas
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Academic Background

B.S.   (1975)  University of Michigan

M.D.  (1980)   University of Michigan

Internship and Residency, Internal Medicine (1980-1983) 

                         George Washington University Hospital

Infectious Diseases Fellowship (1984-1986)

             University of Wisconsin Hospitals and Clinics

Post-doctoral Fellowship (1986-1988)

             University of Wisconsin Hospitals and Clinics

             (Christian R.H. Raetz, mentor)

Post-doctoral Fellowship (1989-1990)

             Merck Research Laboratories, Rahway, NJ

             (Christian R.H. Raetz, mentor)

Assistant Professor of Medicine and Infectious Diseases (1990- 1995)

             Boston University School of Medicine

Associate Professor of Medicine and Infectious Diseases (1995-1999)

             Boston University School of Medicine

Professor of Medicine and Infectious Diseases (1999-2001)

             Boston University School of Medicine

Professor of Medicine and Infectious Diseases (2001-present)

              UMass Medical School

             Tenure award:  2004

           

Innate immunity and Infectious Diseases.Douglas Golenbock, MD

Dr. Douglas Golenbock is Chief of the Division of Infectious Diseases and Immunology in the Department of Medicine. He holds a joint appointment in the Department of Microbiology and Physiological Systems. The goal of his laboratory is to characterize phagocytic receptors that recognize the presence of microbes in the context of infectious illnesses. As the mechanisms of inflammation in infectious diseases are similar to those associated with sterile inflammation, we also study Alzheimer's Disease.    Virtually all of our work focuses on two groups of receptors: Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in the context of the inflammasome.

 Our entry into the TLR field was heralded by the discovery that TLR4, and MD-2 mediate responses to bacterial endotoxin, a major cause of sepsis. More recently, we have begun to focus on intracellular nucleic acid receptors as regulators of IL-1 production and type I interferons. There are six major projects in the laboratory:

1. Defining the response to bacterial lipopolysaccharide (LPS, endotoxin). LPS immunologically potent amphipathic glycolipid on the surface of Gram-negative bacteria. It is thought to be responsible for Gram-negative sepsis. This project involves detailed studies of TLR4/MD-2 and adapter molecules that transduce an activation signal. The work is funded via an NIH merit award to Dr. Golenbock.

2. Characterizing the role of the LPS receptor system, in pelvic inflammatory disease. This project is based upon the realization that Neisseria gonorrhoeae mediates much of its inflammation via the TLR4/MD-2 signaling pathway and is funded via an NIH U19 award that includes other infectious diseases faculty, including Drs. Peter Rice (program PI) and Sanjay Ram.

3. Defining the innate immune response to P. falciparum malaria. Very little is known about how P. falciparum causes inflammation. We have developed several projects in this area, including basic investigations into nucleic acid receptors and inflammasomes. This is a large project that is a collaboration with two other UMass investigators, Drs. Kate Fitzgerald and Ricardo Gazzinelli. The project is funded via an RO1 to Drs. Golenbock and Fitzgerald.

4. Defining the innate immune response to Group B streptococcus. We have previously demonstrated that Group B streptococcus activates type I interferon production as a result of hemolysin expression, which allows DNA access to the phagocyte cytosolic compartment. Recent studies also implicate hemolysin as a mediator of NLRP3 activation via the effects of bacterial RNA. This project is a three way collaboration with a bacterial genetics group at the Institut Pasteur (France) headed by Dr. Patrick Trieu-Cuot and a cell biology group at the University of Freiburg (Germany) run by Dr. Philipp Henneke, a former Golenbock post-doctoral fellow, and is funded by an RO1 grant to Dr. Golenbock.

5. Defining a role for PSTPIP1. PSTPIP1 is a protein that causes an autoinflammatory disorder known as PAPA syndrome: Pogenic Arthritis, Pyoderma gangrenosum and Acne. The disease is due to dysregulation of IL-1 production that probably results from the activation on pyrin, the gene product associated with Familial Mediterranean Fever. Dr. Donghai Wang, a member of the Golenbock laboratory, has engineered mice that are either deficient in PSTPIP1, or that carry the known lesions of PAPA syndrome. It is funded by an R21 grant to Drs. Wang and Golenbock.

6. Examining the role of the NLRP3 inflammasome in Alzheimers Disease. Alzheimer (AD) is a chronic inflammatory disease that causes premature dementia and death. It appears to be caused, in part, by -amyloid, an insoluble protein that activates the NLRP3 inflammasome in microglial cells, resulting in neuronal cell death.

One of the major goals of the Golenbock lab and the Division of Infectious Diseases is to promote UMass immunology and the field of innate immunity in general. The Division has organized the state of the art meetng in the field of innate immunity. We have now had four Toll meetings: Toll2004 (Taormina, Italy), Toll2006 (Salvador, Brazil; www.toll2006.org), Toll2008 (Cascais, Portugal; www.toll2008.org) and Toll2011 (Riva del Garda, Italy; www.toll2011.org). Virtually all of the research faculty, students and post-docs in Infectious Diseases attend the Toll meetings, which typically involve ~ 600 participants.

For More information on Toll related meetings please see

 http://www.youtube.com/watch?v=2rqQOmkiL5o

For More information on Targeting a new therapy for Alzheimer's pleas see:

 http://www.youtube.com/watch?v=5LXshrNFkXA

 
One or more keywords matched the following items that are connected to Golenbock, Douglas
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Academic Article Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
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Academic Article Structure of the monophosphoryl lipid A moiety obtained from the lipopolysaccharide of Chlamydia trachomatis.
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Academic Article The CD11/CD18 integrins: characterization of three novel LPS signaling receptors.
Academic Article Innate immune recognition of lipopolysaccharide by endothelial cells.
Academic Article Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Academic Article Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
Academic Article Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
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Academic Article Lipopolysaccharide-induced stimulation of CD11b/CD18 expression on neutrophils. Evidence of specific receptor-based response and inhibition by lipid A-based antagonists.
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Academic Article Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
Academic Article Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
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Academic Article Adjuvants and their signaling pathways: beyond TLRs.
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Academic Article Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
Academic Article Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
Academic Article Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
Academic Article Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
Academic Article Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression.
Academic Article Non-mannose-capped lipoarabinomannan induces lung inflammation via toll-like receptor 2.
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Academic Article Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
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Academic Article The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
Academic Article Toll-like receptor 2 mediates persistent chemokine release by Chlamydia pneumoniae-infected vascular smooth muscle cells.
Academic Article Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
Academic Article Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
Academic Article Comparative toll-like receptor 4-mediated innate host defense to Bordetella infection.
Academic Article MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
Academic Article Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
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Academic Article A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Academic Article Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
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Academic Article Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
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Academic Article Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Academic Article Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
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Academic Article Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs.
Academic Article Comparative study of lipopolysaccharide-, lipid IVa-, and lipid X-induced tumor necrosis factor production in murine macrophage-like cell lines.
Academic Article Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation.
Academic Article Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.
Academic Article The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article Structural requirements of muramylpeptides for induction of Toll-like receptor 2-mediated NF-kappaB activation in CHO cells.
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Academic Article TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA.
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Academic Article Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
Academic Article Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus.
Academic Article Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
Academic Article A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
Academic Article Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
Academic Article MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
Academic Article Gram-negative endotoxin: a biologically active lipid.
Academic Article Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
Academic Article Innate immune recognition of Yersinia pseudotuberculosis type III secretion.
Academic Article CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
Academic Article LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
Academic Article MD-2 residues tyrosine 42, arginine 69, aspartic acid 122, and leucine 125 provide species specificity for lipid IVA.
Academic Article Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.
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Academic Article Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form Myddosomes.
Academic Article Activation of the NLRP3 inflammasome by group B streptococci.
Academic Article Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
Academic Article DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
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Academic Article Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
Academic Article The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice.
Academic Article Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Academic Article Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
Academic Article A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization.
Academic Article NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Academic Article Dried whole plant Artemisia annua as an antimalarial therapy.
Academic Article Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
Academic Article Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Academic Article Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.
Academic Article CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article Lipid A binding sites in membranes of macrophage tumor cells.
Academic Article Lipid X protects mice against fatal Escherichia coli infection.
Academic Article The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
Academic Article Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
Academic Article Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article Receptor "cross talk" in innate immunity.
Academic Article Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
Academic Article IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Academic Article Recognition and plasma clearance of endotoxin by scavenger receptors.
Academic Article TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
Academic Article Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Academic Article Acyclic analogue of lipid A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway.
Academic Article Soluble CD14 promotes LPS activation of CD14-deficient PNH monocytes and endothelial cells.
Academic Article The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated.
Academic Article Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide.
Academic Article Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.
Academic Article Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans.
Academic Article Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
Academic Article Use of CD14 transfected cells to study LPS-antagonist action.
Academic Article Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
Academic Article Innate immune responses to Rhodococcus equi.
Academic Article The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes.
Academic Article Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
Academic Article Mechanisms of TLR9 activation.
Academic Article Cell activation by Toll-like receptors: role of LBP and CD14.
Academic Article Introduction: Toll receptors come of age.
Academic Article Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
Academic Article Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Academic Article Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Academic Article A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
Academic Article Of mice and man: TLR11 (finally) finds profilin.
Academic Article Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Academic Article Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
Academic Article Peptidoglycan recognition by the Drosophila Imd pathway.
Academic Article Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.
Academic Article The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Academic Article HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
Academic Article MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
Academic Article MD-2.
Academic Article Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Academic Article NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Academic Article Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2.
Academic Article MyD88-dependent activation of dendritic cells and CD4(+) T lymphocytes mediates symptoms, but is not required for the immunological control of parasites during rodent malaria.
Academic Article Ligand-induced conformational changes allosterically activate Toll-like receptor 9.
Academic Article Plasmodium falciparum infection causes proinflammatory priming of human TLR responses.
Academic Article The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14.
Academic Article MUC1 mucin is a negative regulator of toll-like receptor signaling.
Academic Article Failure of TLR4-driven NF-kappa B activation to stimulate virus replication in models of HIV type 1 activation.
Academic Article Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Academic Article Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Academic Article Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
Academic Article Analysis of the activity to induce toll-like receptor (TLR)2- and TLR4-mediated stimulation of supragingival plaque.
Academic Article Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.
Academic Article Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis.
Academic Article IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients.
Academic Article Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Academic Article TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Academic Article TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Academic Article MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
Academic Article Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist.
Academic Article Inflammasomes: too big to miss.
Academic Article MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
Academic Article TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
Academic Article Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Academic Article UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Academic Article TLR3-mediated IFN-? gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Academic Article Macrophages recognize streptococci through bacterial single-stranded RNA.
Academic Article Therapeutical targeting of nucleic acid-sensing Toll-like receptors prevents experimental cerebral malaria.
Academic Article Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis.
Academic Article Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Academic Article Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.
Academic Article NO is a macrophage autonomous modifier of the cytokine response to streptococcal single-stranded RNA.
Academic Article Beyond empiricism: informing vaccine development through innate immunity research.
Academic Article Neutrophil paralysis in Plasmodium vivax malaria.
Academic Article NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
Academic Article Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
Academic Article Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Academic Article UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
Academic Article The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.
Academic Article Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Academic Article The history of Toll-like receptors - redefining innate immunity.
Academic Article Lipid X ameliorates pulmonary hypertension and protects sheep from death due to endotoxin.
Academic Article Elimination and tissue distribution of the monosaccharide lipid A precursor, lipid X, in mice and sheep.
Academic Article CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
Academic Article CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
Academic Article SDZ MRL 953, a lipid A analog as selective cytokine inducer.
Concept Microscopy, Electron, Scanning
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Concept MAP Kinase Signaling System
Concept Mass Spectrometry
Concept Heat-Shock Proteins
Concept Genetic Association Studies
Concept Magnetic Resonance Spectroscopy
Concept Staphylococcal Infections
Concept Epistasis, Genetic
Concept Symbiosis
Concept Mutagenesis, Site-Directed
Concept Polymorphism, Single Nucleotide
Concept Self Tolerance
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Concept Receptors, Cell Surface
Concept Sex Work
Concept HSP70 Heat-Shock Proteins
Concept Schistosoma mansoni
Concept Mycoplasma salivarium
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Concept HIV Seronegativity
Concept Salmonella
Concept Corneal Stroma
Concept Specific Pathogen-Free Organisms
Concept Streptococcus pneumoniae
Concept Anti-Inflammatory Agents, Non-Steroidal
Concept Scavenger Receptors, Class A
Concept Pulmonary Surfactants
Concept Intracellular Signaling Peptides and Proteins
Concept Spectrometry, Mass, Electrospray Ionization
Concept Cell-Free System
Concept Culture Media, Serum-Free
Concept Statistics, Nonparametric
Concept Mycobacterium smegmatis
Concept Static Electricity
Concept Salmonella Infections, Animal
Concept Molecular Structure
Concept Intercellular Signaling Peptides and Proteins
Concept Binding Sites, Antibody
Concept Conserved Sequence
Concept Immune Sera
Concept HSP90 Heat-Shock Proteins
Concept Seizures
Concept Growth Substances
Concept Pulmonary Surfactant-Associated Proteins
Concept Adjuvants, Immunologic
Concept Nod2 Signaling Adaptor Protein
Concept Sequence Deletion
Concept Multicenter Studies as Topic
Concept Species Specificity
Concept Cell Separation
Concept Nitric Oxide Synthase
Concept Rhodobacter sphaeroides
Concept Granulocyte-Macrophage Colony-Stimulating Factor
Concept Drug Synergism
Concept Receptor-Interacting Protein Serine-Threonine Kinases
Concept Signal Transduction
Concept Spectrophotometry
Concept Succinates
Concept Severity of Illness Index
Concept Protein Structure, Secondary
Concept Reactive Oxygen Species
Concept Sepsis
Concept Protein Structure, Tertiary
Concept Adaptor Proteins, Signal Transducing
Concept Interleukin-18 Receptor alpha Subunit
Concept Genes, Bacterial
Concept Solubility
Concept Genes, Reporter
Concept Antigens, Surface
Concept Survival Analysis
Concept Sialoglycoproteins
Concept S-Adenosylmethionine
Concept AT Rich Sequence
Concept Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Concept Sheep
Concept Streptococcus mutans
Concept Protein Stability
Concept Sequence Alignment
Concept Respiratory Syncytial Virus Infections
Concept Synteny
Concept Protein Structure, Quaternary
Concept Electrophoretic Mobility Shift Assay
Concept Amyloid Precursor Protein Secretases
Concept Binding Sites
Concept Mass Screening
Concept Saccharomyces cerevisiae Proteins
Concept Interleukin-12 Subunit p40
Concept Carbohydrate Sequence
Concept Case-Control Studies
Concept Mice, Inbred Strains
Concept Antibody Specificity
Concept Macromolecular Substances
Concept Prospective Studies
Concept Cross-Sectional Studies
Concept Sequence Homology, Amino Acid
Concept Spectrometry, Mass, Secondary Ion
Concept Immunoglobulin Class Switching
Concept Spleen
Concept Sequence Homology, Nucleic Acid
Concept In Situ Hybridization
Concept Substrate Specificity
Concept Genome-Wide Association Study
Concept Nitric Oxide Synthase Type II
Concept Streptolysins
Concept Oligonucleotide Array Sequence Analysis
Concept Sulfones
Concept Shock, Septic
Concept Rats, Sprague-Dawley
Concept Respiratory Syncytial Virus, Human
Concept United States
Concept Serine
Concept Steroid Hydroxylases
Concept Lupus Erythematosus, Systemic
Concept Sulfonamides
Concept Receptors, Scavenger
Concept Structure-Activity Relationship
Concept Superoxides
Concept Skin
Concept Nod1 Signaling Adaptor Protein
Concept Secretory Pathway
Concept Pulmonary Surfactant-Associated Protein A
Concept Streptococcus agalactiae
Concept Base Sequence
Concept Alleles
Concept Salmonella typhimurium
Concept Mice, Mutant Strains
Concept Molecular Sequence Data
Concept CARD Signaling Adaptor Proteins
Concept RNA, Double-Stranded
Concept Surface Properties
Academic Article Increased survival in B-cell-deficient mice during experimental cerebral malaria suggests a role for circulating immune complexes.
Academic Article The genome of Anopheles darlingi, the main neotropical malaria vector.
Academic Article Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Academic Article Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article TRIF signaling is essential for TLR4-driven IgE class switching.
Academic Article 3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
Academic Article Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.
Academic Article RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
Academic Article Hemolysis-induced lethality involves inflammasome activation by heme.
Academic Article The CD14+CD16+ inflammatory monocyte subset displays increased mitochondrial activity and effector function during acute Plasmodium vivax malaria.
Academic Article Innate sensing of malaria parasites.
Academic Article Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production.
Academic Article MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
Academic Article Involvement of Nod2 in the innate immune response elicited by malarial pigment hemozoin.
Academic Article Neuroinflammation in Alzheimer's disease.
Academic Article LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.
Academic Article Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria.
Academic Article Absence of infection with human immunodeficiency virus in Peruvian prostitutes.
Academic Article Pyomyositis and hepatic abscess in association with Aeromonas hydrophila sepsis.
Academic Article Interlaboratory variability of CD8 subset measurements by flow cytometry and its applications to multicenter clinical trials. NAID/NICHD Women and Infants Transmission Study Group.
Academic Article A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
Academic Article A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling.
Academic Article Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Academic Article A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.
Academic Article Control of the innate immune response by the mevalonate pathway.
Academic Article miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Academic Article Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
Academic Article Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice.
Academic Article Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Academic Article Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Academic Article Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
Academic Article A guiding map for inflammation.
Academic Article Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.
Academic Article Daily Rhythms of TNFa Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.
Academic Article Targeting the IL33-NLRP3 axis improves therapy for experimental cerebral malaria.
Academic Article The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.
Academic Article The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
Academic Article Systemic inflammation impairs microglial A? clearance through NLRP3 inflammasome.
Academic Article Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
Academic Article The immunology of Plasmodium vivax malaria.
Academic Article NLRP3 inflammasome activation drives tau pathology.
Academic Article Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors.
Academic Article Integrative analysis of microRNA and mRNA expression profiles of monocyte-derived dendritic cells differentiation during experimental cerebral malaria.
Academic Article Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.
Academic Article CXCR3 chemokine receptor contributes to specific CD8+?T cell activation by pDC during infection with intracellular pathogens.
Academic Article Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling.
Academic Article Caspase-8 mediates inflammation and disease in rodent malaria.
Academic Article Author Correction: A guiding map for inflammation.
Academic Article Correction: CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens.
Academic Article Asymptomatic Plasmodium vivax malaria in the Brazilian Amazon: Submicroscopic parasitemic blood infects Nyssorhynchus darlingi.
Academic Article Weekly SARS-CoV-2 screening of asymptomatic kindergarten to grade 12 students and staff helps inform strategies for safer in-person learning.
Concept Mice, 129 Strain
Concept Bacterial Secretion Systems
Concept Molecular Sequence Annotation
Concept Transcriptome
Concept Spike Glycoprotein, Coronavirus
Concept Spatial Memory
Academic Article Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.
Academic Article Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient.
Academic Article Lymphocyte crosstalk is required for monocyte-intrinsic trained immunity to Plasmodium falciparum.
Academic Article The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.
Academic Article Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil.
Academic Article Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation.
Academic Article Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells.
Academic Article The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
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