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Golenbock, Douglas

One or more keywords matched the following items that are connected to Golenbock, Douglas

Item Type	Name
Academic Article	Engagement of the Lewis X antigen (CD15) results in monocyte activation.
Academic Article	Lipopolysaccharide antagonists.
Academic Article	Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact.
Academic Article	CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin.
Academic Article	CD11/CD18 and CD14 share a common lipid A signaling pathway.
Academic Article	Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.
Academic Article	Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.
Academic Article	Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
Academic Article	Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
Academic Article	Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2.
Academic Article	Bacterial lipopolysaccharide induces expression of the stress response genes hop and H411.
Academic Article	Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis.
Academic Article	Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products.
Academic Article	The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
Academic Article	A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.
Academic Article	Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
Academic Article	Involvement of CD14 and beta2-integrins in activating cells with soluble and particulate lipopolysaccharides and mannuronic acid polymers.
Academic Article	Structure and function of Toll-like receptor proteins.
Academic Article	Differential effects of a Toll-like receptor antagonist on Mycobacterium tuberculosis-induced macrophage responses.
Academic Article	Membrane-associated proteins of a lipopolysaccharide-deficient mutant of Neisseria meningitidis activate the inflammatory response through toll-like receptor 2.
Academic Article	Stimulation of macrophages by lipopolysaccharide alters the phosphorylation state, conformation, and function of PU.1 via activation of casein kinase II.
Academic Article	Toll-like receptor 2-dependent inhibition of macrophage class II MHC expression and antigen processing by 19-kDa lipoprotein of Mycobacterium tuberculosis.
Academic Article	Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4.
Academic Article	Innate immune recognition of lipopolysaccharide by endothelial cells.
Academic Article	Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14.
Academic Article	Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
Academic Article	LPS-binding proteins and receptors.
Academic Article	Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
Academic Article	Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Academic Article	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
Academic Article	Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
Academic Article	Adjuvants and their signaling pathways: beyond TLRs.
Academic Article	The LPS receptor generates inflammatory signals from the cell surface.
Academic Article	Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.
Academic Article	Biological activities of Bacteroides forsythus lipoproteins and their possible pathological roles in periodontal disease.
Academic Article	Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6.
Academic Article	Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression.
Academic Article	LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.
Academic Article	Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation.
Academic Article	Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation.
Academic Article	The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
Academic Article	MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection.
Academic Article	Human phagocytes have multiple lipid A-binding sites.
Academic Article	Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
Academic Article	Lipopolysaccharide binding protein-deficient mice have a normal defense against pulmonary mycobacterial infection.
Academic Article	Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent.
Academic Article	The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease.
Academic Article	Toll-like receptor 2 mediates inflammatory cytokine induction but not sensitization for liver injury by Propioni- bacterium acnes.
Academic Article	Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide.
Academic Article	Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
Academic Article	MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
Academic Article	Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo.
Academic Article	The biology of Toll-like receptors.
Academic Article	A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
Academic Article	Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Academic Article	Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
Academic Article	Toll-like receptor-dependent discrimination of streptococci.
Academic Article	Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.
Academic Article	Extolling the diversity of bacterial endotoxins.
Academic Article	Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Academic Article	Immunology. The shape of things to come.
Academic Article	YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
Academic Article	Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
Academic Article	Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
Academic Article	Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
Academic Article	Bacterial fimbriae stimulate proinflammatory activation in the endothelium through distinct TLRs.
Academic Article	The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Academic Article	Recombinant Ov-ASP-1, a Th1-biased protein adjuvant derived from the helminth Onchocerca volvulus, can directly bind and activate antigen-presenting cells.
Academic Article	Novel engagement of CD14 and multiple toll-like receptors by group B streptococci.
Academic Article	Innate immune recognition of Yersinia pseudotuberculosis type III secretion.
Academic Article	LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection.
Academic Article	Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation.
Academic Article	Activation of the NLRP3 inflammasome by group B streptococci.
Academic Article	Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
Academic Article	Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
Academic Article	NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.
Academic Article	Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.
Academic Article	Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.
Academic Article	CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation.
Academic Article	Lipid A binding sites in membranes of macrophage tumor cells.
Academic Article	The antifungal drug amphotericin B promotes inflammatory cytokine release by a Toll-like receptor- and CD14-dependent mechanism.
Academic Article	Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
Academic Article	Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
Academic Article	LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Academic Article	Lipopolysaccharide binding protein is an essential component of the innate immune response to Escherichia coli peritonitis in mice.
Academic Article	IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts.
Academic Article	TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Academic Article	Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human toll-like receptor 2 (TLR2) and requires the presence of TLR2 for optimal immunogenicity.
Academic Article	Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide.
Academic Article	Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease.
Academic Article	Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
Academic Article	Innate immune responses to Rhodococcus equi.
Academic Article	The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
Academic Article	Cell activation by Toll-like receptors: role of LBP and CD14.
Academic Article	Introduction: Toll receptors come of age.
Academic Article	Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
Academic Article	Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Academic Article	A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A.
Academic Article	Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
Academic Article	Peptidoglycan recognition by the Drosophila Imd pathway.
Academic Article	The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Academic Article	Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
Academic Article	MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
Academic Article	Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
Academic Article	MUC1 mucin is a negative regulator of toll-like receptor signaling.
Academic Article	Lymphocytic choriomeningitis virus (LCMV) infection of CNS glial cells results in TLR2-MyD88/Mal-dependent inflammatory responses.
Academic Article	Lipoproteins are critical TLR2 activating toxins in group B streptococcal sepsis.
Academic Article	IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients.
Academic Article	TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway.
Academic Article	Inflammasomes: too big to miss.
Academic Article	Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
Academic Article	UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Academic Article	TLR3-mediated IFN-? gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Academic Article	Macrophages recognize streptococci through bacterial single-stranded RNA.
Academic Article	Toll-like receptors participate in macrophage activation and intracellular control of Leishmania (Viannia) panamensis.
Academic Article	Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Academic Article	Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Academic Article	NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1? and neuronal toxicity.
Academic Article	Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
Academic Article	Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Academic Article	UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
Academic Article	The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.
Academic Article	Interferon-? and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING).
Academic Article	CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
Academic Article	CD14 enhances cellular responses to endotoxin without imparting ligand-specific recognition.
Concept	Membrane Proteins
Concept	Hemolysin Proteins
Concept	DNA-Binding Proteins
Concept	Heat-Shock Proteins
Concept	ADAM Proteins
Concept	Muscle Proteins
Concept	Phosphate-Binding Proteins
Concept	GTP-Binding Proteins
Concept	Helminth Proteins
Concept	Carrier Proteins
Concept	Luminescent Proteins
Concept	Nuclear Proteins
Concept	Recombinant Proteins
Concept	Acute-Phase Proteins
Concept	Intracellular Signaling Peptides and Proteins
Concept	tau Proteins
Concept	Dystrophin-Associated Proteins
Concept	Viral Proteins
Concept	Intercellular Signaling Peptides and Proteins
Concept	rab GTP-Binding Proteins
Concept	Myelin Proteins
Concept	Proto-Oncogene Proteins c-akt
Concept	Proteins
Concept	Viral Core Proteins
Concept	Membrane Transport Proteins
Concept	Cytoskeletal Proteins
Concept	Adaptor Proteins, Signal Transducing
Concept	Green Fluorescent Proteins
Concept	Bacterial Proteins
Concept	Recombinant Fusion Proteins
Concept	Calcium-Binding Proteins
Concept	Bacterial Outer Membrane Proteins
Concept	Viral Nonstructural Proteins
Concept	Opsonin Proteins
Concept	Fungal Proteins
Concept	Saccharomyces cerevisiae Proteins
Concept	Proto-Oncogene Proteins c-jun
Concept	Drosophila Proteins
Concept	Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Concept	Insect Proteins
Concept	Viral Fusion Proteins
Concept	Adaptor Proteins, Vesicular Transport
Concept	Apoptosis Regulatory Proteins
Concept	Cation Transport Proteins
Concept	Proto-Oncogene Proteins
Concept	Blood Proteins
Concept	Viral Envelope Proteins
Concept	Protozoan Proteins
Concept	Fimbriae Proteins
Concept	CARD Signaling Adaptor Proteins
Academic Article	The genome of Anopheles darlingi, the main neotropical malaria vector.
Academic Article	Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
Academic Article	Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Academic Article	Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
Academic Article	TRIF signaling is essential for TLR4-driven IgE class switching.
Academic Article	Escherichia coli isolates from inflammatory bowel diseases patients survive in macrophages and activate NLRP3 inflammasome.
Academic Article	RNA and ?-hemolysin of group B Streptococcus induce interleukin-1? (IL-1?) by activating NLRP3 inflammasomes in mouse macrophages.
Academic Article	Hemolysis-induced lethality involves inflammasome activation by heme.
Academic Article	Metalloproteinase-dependent TLR2 ectodomain shedding is involved in soluble toll-like receptor 2 (sTLR2) production.
Academic Article	LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.
Academic Article	A Novel Factor H-Fc Chimeric Immunotherapeutic Molecule against Neisseria gonorrhoeae.
Academic Article	Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.
Academic Article	A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In?Vivo Infection.
Academic Article	Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.
Academic Article	miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
Academic Article	Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
Academic Article	Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Academic Article	Microglia-derived ASC specks cross-seed amyloid-? in Alzheimer's disease.
Academic Article	The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
Academic Article	Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.
Academic Article	NLRP3 inflammasome activation drives tau pathology.
Concept	Prion Proteins
Concept	Myelin and Lymphocyte-Associated Proteolipid Proteins
Academic Article	The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.

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