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Academic Article
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Mycobacterial lipoarabinomannan recognition requires a receptor that shares components of the endotoxin signaling system.
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Academic Article
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Engagement of the Lewis X antigen (CD15) results in monocyte activation.
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Academic Article
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CD11/CD18 leukocyte integrins: new signaling receptors for bacterial endotoxin.
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Academic Article
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CD11/CD18 and CD14 share a common lipid A signaling pathway.
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Academic Article
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Heterotrimeric G proteins physically associated with the lipopolysaccharide receptor CD14 modulate both in vivo and in vitro responses to lipopolysaccharide.
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Academic Article
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Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction.
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Academic Article
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Lipopolysaccharide recognition, CD14, and lipopolysaccharide receptors.
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Academic Article
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Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.
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Academic Article
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The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.
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Academic Article
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A novel synthetic acyclic lipid A-like agonist activates cells via the lipopolysaccharide/toll-like receptor 4 signaling pathway.
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Academic Article
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Divergent response to LPS and bacteria in CD14-deficient murine macrophages.
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Academic Article
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Structure and function of Toll-like receptor proteins.
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Academic Article
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Outside-in signaling by lipopolysaccharide through a tailless integrin.
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Academic Article
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Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls.
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Academic Article
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The CD11/CD18 integrins: characterization of three novel LPS signaling receptors.
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Academic Article
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Innate immune recognition of lipopolysaccharide by endothelial cells.
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Academic Article
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Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4.
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Academic Article
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Toll-like receptor (TLR) signaling in response to Aspergillus fumigatus.
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Academic Article
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Construction of a lipopolysaccharide reporter cell line and its use in identifying mutants defective in endotoxin, but not TNF-alpha, signal transduction.
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Academic Article
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Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
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Academic Article
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Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells.
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Academic Article
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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway.
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Academic Article
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Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.
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Academic Article
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Adjuvants and their signaling pathways: beyond TLRs.
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Academic Article
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The LPS receptor generates inflammatory signals from the cell surface.
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Academic Article
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Membrane expression of soluble endotoxin-binding proteins permits lipopolysaccharide signaling in Chinese hamster ovary fibroblasts independently of CD14.
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Academic Article
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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways.
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Academic Article
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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
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Academic Article
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Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.
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Academic Article
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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
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Academic Article
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Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling.
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Academic Article
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Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide.
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Academic Article
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MyD88-dependent pathways mediate resistance to Cryptosporidium parvum infection in mice.
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Academic Article
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Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.
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Academic Article
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Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2-and TLR4-independent signaling.
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Academic Article
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The biology of Toll-like receptors.
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Academic Article
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A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.
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Academic Article
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Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.
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Academic Article
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Toll-like receptor-dependent discrimination of streptococci.
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Academic Article
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Extolling the diversity of bacterial endotoxins.
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Academic Article
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Immunology. The shape of things to come.
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Academic Article
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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells.
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Academic Article
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YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction.
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Academic Article
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Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite.
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Academic Article
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Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.
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Academic Article
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Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.
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Academic Article
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TIRAP: how Toll receptors fraternize.
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Academic Article
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Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide.
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Academic Article
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A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.
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Academic Article
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Mal connects TLR2 to PI3Kinase activation and phagocyte polarization.
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Academic Article
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MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3.
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Academic Article
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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer.
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Academic Article
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Activation of the NLRP3 inflammasome by group B streptococci.
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Academic Article
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An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration.
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Academic Article
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Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation.
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Academic Article
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Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers.
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Academic Article
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Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.
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Academic Article
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Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.
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Academic Article
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Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling.
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Academic Article
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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
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Academic Article
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Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs.
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Academic Article
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
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Academic Article
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CD14-mediated translocation of nuclear factor-kappa B induced by lipopolysaccharide does not require tyrosine kinase activity.
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Academic Article
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Acyclic analogue of lipid A stimulates TNF-alpha and arachidonate release via a unique LPS-signaling pathway.
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Academic Article
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The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated.
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Academic Article
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Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide.
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Academic Article
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Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin.
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Academic Article
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Use of CD14 transfected cells to study LPS-antagonist action.
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Academic Article
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Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway.
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Academic Article
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The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades.
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Academic Article
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Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
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Academic Article
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Mechanisms of TLR9 activation.
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Academic Article
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Endotoxin recognition and signal transduction by the TLR4/MD2-complex.
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Academic Article
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Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
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Academic Article
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Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.
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Academic Article
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Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.
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Academic Article
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Peptidoglycan recognition by the Drosophila Imd pathway.
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Academic Article
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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
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Academic Article
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Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling.
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Academic Article
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HMGB1 signals through toll-like receptor (TLR) 4 and TLR2.
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Academic Article
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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals.
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Academic Article
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Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.
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Academic Article
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Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
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Academic Article
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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
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Academic Article
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MUC1 mucin is a negative regulator of toll-like receptor signaling.
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Academic Article
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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
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Academic Article
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MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses.
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Academic Article
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Inflammasomes: too big to miss.
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Academic Article
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MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
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Academic Article
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TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia.
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Academic Article
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Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule.
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Academic Article
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TLR3-mediated IFN-? gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
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Academic Article
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Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
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Academic Article
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Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.
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Academic Article
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Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
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Academic Article
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The Abi-domain protein Abx1 interacts with the CovS histidine kinase to control virulence gene expression in group B Streptococcus.
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Academic Article
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The history of Toll-like receptors - redefining innate immunity.
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Academic Article
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CD11c/CD18, a transmembrane signaling receptor for lipopolysaccharide.
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Concept
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Signal Transduction
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Academic Article
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Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection.
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Academic Article
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TRIF signaling is essential for TLR4-driven IgE class switching.
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Academic Article
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3-Hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statin)-induced 28-kDa interleukin-1? interferes with mature IL-1? signaling.
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Academic Article
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MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
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Academic Article
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Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria.
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Academic Article
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Control of the innate immune response by the mevalonate pathway.
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Academic Article
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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).
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Academic Article
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Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.
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Academic Article
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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2.
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Academic Article
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Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling.
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Academic Article
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The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways.
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